Search Results - "Amigorena, Sebastian"

Dendritic Cells on the Way to Glory by Amigorena, Sebastian

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Regulation of Antigen Export to the Cytosol During Cross-Presentation by Gros, Marine, Amigorena, Sebastian

“…Cross-priming refers to the induction of primary cytotoxic CD8 T cell responses to antigens that are not expressed in antigen presenting cells (APCs)…”
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Similar antigen cross-presentation capacity and phagocytic functions in all freshly isolated human lymphoid organ-resident dendritic cells by Segura, Elodie, Durand, Mélanie, Amigorena, Sebastian

“…Dendritic cells (DCs) represent a heterogeneous population of antigen-presenting cells that initiate and orient immune responses in secondary lymphoid organs…”
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Phagocytosis and antigen presentation in dendritic cells by Savina, Ariel, Amigorena, Sebastian

“…Like macrophages and neutrophils, dendritic cells (DCs) are considered professional phagocytes. Even if the three cell types phagocytose parasites, bacteria,…”
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Cold Tumors: A Therapeutic Challenge for Immunotherapy by Bonaventura, Paola, Shekarian, Tala, Alcazer, Vincent, Valladeau-Guilemond, Jenny, Valsesia-Wittmann, Sandrine, Amigorena, Sebastian, Caux, Christophe, Depil, Stéphane

“…Therapeutic monoclonal antibodies targeting immune checkpoints (ICPs) have changed the treatment landscape of many tumors. However, response rate remains…”
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Intracellular mechanisms of antigen cross presentation in dendritic cells by Amigorena, Sebastian, Savina, Ariel

“…The induction of most CD8+ T cell responses by dendritic cells (DCs) requires the presentation of peptides from internalized antigen by class I MHC molecules…”
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Dendritic cell maturation and cross-presentation: timing matters by Alloatti, Andrés, Kotsias, Fiorella, Magalhaes, Joao Gamelas, Amigorena, Sebastian

“…Summary As a population, dendritic cells (DCs) appear to be the best cross‐presenters of internalized antigens on major histocompatibility complex class I…”
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Tumor invasion in draining lymph nodes is associated with Treg accumulation in breast cancer patients by Núñez, Nicolas Gonzalo, Tosello Boari, Jimena, Ramos, Rodrigo Nalio, Richer, Wilfrid, Cagnard, Nicolas, Anderfuhren, Cyrill Dimitri, Niborski, Leticia Laura, Bigot, Jeremy, Meseure, Didier, De La Rochere, Philippe, Milder, Maud, Viel, Sophie, Loirat, Delphine, Pérol, Louis, Vincent-Salomon, Anne, Sastre-Garau, Xavier, Burkhard, Becher, Sedlik, Christine, Lantz, Olivier, Amigorena, Sebastian, Piaggio, Eliane

“…Tumor-draining lymph node (TDLN) invasion by metastatic cells in breast cancer correlates with poor prognosis and is associated with local immunosuppression,…”
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The receptor DNGR-1 signals for phagosomal rupture to promote cross-presentation of dead-cell-associated antigens by Canton, Johnathan, Blees, Hanna, Henry, Conor M., Buck, Michael D., Schulz, Oliver, Rogers, Neil C., Childs, Eleanor, Zelenay, Santiago, Rhys, Hefin, Domart, Marie-Charlotte, Collinson, Lucy, Alloatti, Andres, Ellison, Cara J., Amigorena, Sebastian, Papayannopoulos, Venizelos, Thomas, David C., Randow, Felix, Reis e Sousa, Caetano

“…Type 1 conventional dendritic (cDC1) cells are necessary for cross-presentation of many viral and tumor antigens to CD8 + T cells. cDC1 cells can be identified…”
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Critical role for Sec22b-dependent antigen cross-presentation in antitumor immunity by Alloatti, Andrés, Rookhuizen, Derek C, Joannas, Leonel, Carpier, Jean-Marie, Iborra, Salvador, Magalhaes, Joao G, Yatim, Nader, Kozik, Patrycja, Sancho, David, Albert, Matthew L, Amigorena, Sebastian

“…CD8 T cells mediate antigen-specific immune responses that can induce rejection of solid tumors. In this process, dendritic cells (DCs) are thought to take up…”
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A multiscale signalling network map of innate immune response in cancer reveals cell heterogeneity signatures by Kondratova, Maria, Czerwinska, Urszula, Sompairac, Nicolas, Amigorena, Sebastian D., Soumelis, Vassili, Barillot, Emmanuel, Zinovyev, Andrei, Kuperstein, Inna

“…The lack of integrated resources depicting the complexity of the innate immune response in cancer represents a bottleneck for high-throughput data…”
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The epigenetic control of stemness in CD8 + T cell fate commitment by Pace, Luigia, Goudot, Christel, Zueva, Elina, Gueguen, Paul, Burgdorf, Nina, Waterfall, Joshua J, Quivy, Jean-Pierre, Almouzni, Geneviève, Amigorena, Sebastian

“…After priming, naïve CD8 T lymphocytes establish specific heritable transcription programs that define progression to long-lasting memory cells or to…”
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Reactive oxygen species production in the phagosome: impact on antigen presentation in dendritic cells by Kotsias, Fiorella, Hoffmann, Eik, Amigorena, Sebastian, Savina, Ariel

“…The NADPH oxidase 2 (NOX2) is known to play a major role in innate immunity for several decades. Phagocytic cells provide host defense by ingesting microbes…”
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Intrinsic antiproliferative activity of the innate sensor STING in T lymphocytes by Cerboni, Silvia, Jeremiah, Nadia, Gentili, Matteo, Gehrmann, Ulf, Conrad, Cécile, Stolzenberg, Marie-Claude, Picard, Capucine, Neven, Bénédicte, Fischer, Alain, Amigorena, Sébastian, Rieux-Laucat, Frédéric, Manel, Nicolas

“…Activation of the cyclic dinucleotide sensor stimulator of interferon (IFN) genes (STING) is critical for IFN and inflammatory gene expression during innate…”
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Human in vivo-generated monocyte-derived dendritic cells and macrophages cross-present antigens through a vacuolar pathway by Tang-Huau, Tsing-Lee, Gueguen, Paul, Goudot, Christel, Durand, Mélanie, Bohec, Mylène, Baulande, Sylvain, Pasquier, Benoit, Amigorena, Sebastian, Segura, Elodie

“…Presentation of exogenous antigens on MHC-I molecules, termed cross-presentation, is essential for cytotoxic CD8 + T cell responses. In mice, dendritic cells…”
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Lipid-Associated Macrophages Are Induced by Cancer-Associated Fibroblasts and Mediate Immune Suppression in Breast Cancer by Timperi, Eleonora, Gueguen, Paul, Molgora, Martina, Magagna, Ilaria, Kieffer, Yann, Lopez-Lastra, Silvia, Sirven, Philemon, Baudrin, Laura G., Baulande, Sylvain, Nicolas, André, Champenois, Gabriel, Meseure, Didier, Vincent-Salomon, Anne, Tardivon, Anne, Laas, Enora, Soumelis, Vassili, Colonna, Marco, Mechta-Grigoriou, Fatima, Amigorena, Sebastian, Romano, Emanuela

“…Abstract Tumor-associated macrophages (TAM) play a detrimental role in triple-negative breast cancer (TNBC). In-depth analysis of TAM characteristics and…”
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Characterization of resident and migratory dendritic cells in human lymph nodes by Segura, Elodie, Valladeau-Guilemond, Jenny, Donnadieu, Marie-Hélène, Sastre-Garau, Xavier, Soumelis, Vassili, Amigorena, Sebastian

“…Dendritic cells (DCs) initiate adaptive immune responses in lymph nodes (LNs). In mice, LN DCs can be divided into resident and tissue-derived populations, the…”
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Mitochondrial reactive oxygen species regulate the induction of CD8+ T cells by plasmacytoid dendritic cells by Oberkampf, Marine, Guillerey, Camille, Mouriès, Juliette, Rosenbaum, Pierre, Fayolle, Catherine, Bobard, Alexandre, Savina, Ariel, Ogier-Denis, Eric, Enninga, Jost, Amigorena, Sebastian, Leclerc, Claude, Dadaglio, Gilles

“…Cross-presentation allows exogenous antigen presentation in association with major histocompatibility complex class I molecules, a process crucial for the…”
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Adjustment of dendritic cells to the breast-cancer microenvironment is subset specific by Michea, Paula, Noël, Floriane, Zakine, Eve, Czerwinska, Urszula, Sirven, Philémon, Abouzid, Omar, Goudot, Christel, Scholer-Dahirel, Alix, Vincent-Salomon, Anne, Reyal, Fabien, Amigorena, Sebastian, Guillot-Delost, Maude, Segura, Elodie, Soumelis, Vassili

“…The functions and transcriptional profiles of dendritic cells (DCs) result from the interplay between ontogeny and tissue imprinting. How tumors shape human…”
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Isolation and characterization of exosomes from cell culture supernatants and biological fluids by Théry, Clotilde, Amigorena, Sebastian, Raposo, Graça, Clayton, Aled

“…Exosomes are small membrane vesicles found in cell culture supernatants and in different biological fluids. Exosomes form in a particular population of…”
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