Search Results - "Ames, Samantha"

The proteoglycan-like domain of carbonic anhydrase IX mediates non-catalytic facilitation of lactate transport in cancer cells by Ames, Samantha, Pastorekova, Silvia, Becker, Holger M

“…Highly glycolytic tumor cells release vast amounts of lactate and protons via monocarboxylate transporters (MCTs), which exacerbate extracellular acidification…”
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Hypoxia-induced carbonic anhydrase IX facilitates lactate flux in human breast cancer cells by non-catalytic function by Jamali, Somayeh, Klier, Michael, Ames, Samantha, Felipe Barros, L., McKenna, Robert, Deitmer, Joachim W., Becker, Holger M.

“…The most aggressive tumour cells, which often reside in hypoxic environments, rely on glycolysis for energy production. Thereby they release vast amounts of…”
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A surface proton antenna in carbonic anhydrase II supports lactate transport in cancer cells by Noor, Sina Ibne, Jamali, Somayeh, Ames, Samantha, Langer, Silke, Deitmer, Joachim W, Becker, Holger M

“…Many tumor cells produce vast amounts of lactate and acid, which have to be removed from the cell to prevent intracellular lactacidosis and suffocation of…”
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Modeling of pH regulation in tumor cells: Direct interaction between proton-coupled lactate transporters and cancer-associated carbonicanhydrase by Athni Hiremath, Sandesh, Surulescu, Christina, Jamali, Somayeh, Ames, Samantha, W. Deitmer, Joachim, M. Becker, Holger

“…The most aggressive tumor cells, which often reside in a hypoxic environment, can release vast amounts of lactate and protons via monocarboxylate transporters…”
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CAIX forms a transport metabolon with monocarboxylate transporters in human breast cancer cells by Ames, Samantha, Andring, Jacob T., McKenna, Robert, Becker, Holger M.

“…Tumor cells rely on glycolysis to meet their elevated demand for energy. Thereby they produce significant amounts of lactate and protons, which are exported…”
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Membrane-anchored carbonic anhydrase IV interacts with monocarboxylate transporters via their chaperones CD147 and GP70 by Forero-Quintero, Linda S., Ames, Samantha, Schneider, Hans-Peter, Thyssen, Anne, Boone, Christopher D., Andring, Jacob T., McKenna, Robert, Casey, Joseph R., Deitmer, Joachim W., Becker, Holger M.

“…Monocarboxylate transporters (MCTs) mediate the proton-coupled exchange of high-energy metabolites, including lactate and pyruvate, between cells and tissues…”
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Catalytic activity of human carbonic anhydrase isoform IX is displayed both extra‐ and intracellularly by Klier, Michael, Jamali, Somayeh, Ames, Samantha, Schneider, Hans‐Peter, Becker, Holger M, Deitmer, Joachim W

“…Most carbonic anhydrases catalyse the reversible conversion of carbon dioxide to protons and bicarbonate, either as soluble cytosolic enzymes, in or at…”
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Selective inhibition of human carbonic anhydrase IX in Xenopus oocytes and MDA-MB-231 breast cancer cells by Kazokaitė, Justina, Ames, Samantha, Becker, Holger M, Deitmer, Joachim W, Matulis, Daumantas

“…Human carbonic anhydrase IX (CA IX) is overexpressed in the most aggressive and invasive tumors. Therefore, CA IX has become the promising antitumor drug…”
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Modeling of pH regulation in tumor cells: Direct interaction between proton-coupled lactate transporters and cancer-associated carbonic anhydrase by Hiremath, Sandesh Athni, Surulescu, Christina, Jamali, Somayeh, Ames, Samantha, Deitmer, Joachim W, Becker, Holger M

“…The most aggressive tumor cells, which often reside in a hypoxic environment, can release vast amounts of lactate and protons via monocarboxylate transporters…”
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Adolescents referred following overdose: Support for Hawton's classification and the role of a primary child and adolescent mental health worker by Davies, Gillian, Ames, Samantha

“…Services for adolescents who overdose remain variable in the UK despite College guidelines. The problem is significant in terms of the demand placed on…”
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