Search Results - "Ames, R S"

Receptor for the C3a anaphylatoxin is expressed by neurons and glial cells by Davoust, Nathalie, Jones, Jennifer, Stahel, Philip F., Ames, Robert S., Barnum, Scott R.

“…Little is known about the expression of the receptor for complement anaphylatoxin C3a (C3aR) in the central nervous system (CNS). In this study, we provide the…”
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Cutting Edge: Guinea Pigs with a Natural C3a-Receptor Defect Exhibit Decreased Bronchoconstriction in Allergic Airway Disease: Evidence for an Involvement of the C3a Anaphylatoxin in the Pathogenesis of Asthma by Bautsch, Wilfried, Hoymann, Heinz-Gerd, Zhang, Qiuwang, Meier-Wiedenbach, Ivo, Raschke, Ursula, Ames, Robert S, Sohns, Bettina, Flemme, Nicole, Meyer zu Vilsendorf, Andreas, Grove, Melanie, Klos, Andreas, Kohl, Jorg

“…Asthma is a major cause of morbidity worldwide with prevalence and severity still increasing at an alarming pace. Hallmarks of this disease include early-phase…”
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TNF-alpha-mediated expression of the receptor for anaphylatoxin C5a on neurons in experimental Listeria meningoencephalitis by Stahel, PF, Frei, K, Eugster, HP, Fontana, A, Hummel, KM, Wetsel, RA, Ames, RS, Barnum, SR

“…The anaphylatoxin C5a has been implicated in the pathogenesis of bacterial meningitis as a potent mediator of inflammation in the subarachnoid space. We…”
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The mouse anaphylatoxin C3a receptor: molecular cloning, genomic organization, and functional expression by Tornetta, MA, Foley, JJ, Sarau, HM, Ames, RS

“…The anaphylatoxin C3a receptor (C3aR) is unique among the family of G protein-coupled receptors in possessing an unusually large predicted second extracellular…”
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Cloning, expression, and pharmacological characterization of a novel human histamine receptor by Zhu, Y, Michalovich, D, Wu, H, Tan, K B, Dytko, G M, Mannan, I J, Boyce, R, Alston, J, Tierney, L A, Li, X, Herrity, N C, Vawter, L, Sarau, H M, Ames, R S, Davenport, C M, Hieble, J P, Wilson, S, Bergsma, D J, Fitzgerald, L R

“…Using a genomics-based reverse pharmacological approach for screening orphan G-protein coupled receptors, we have identified and cloned a novel high-affinity…”
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Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1 by Chambers, Jon, Ames, Robert S, Bergsma, Derk, Muir, Alison, Fitzgerald, Laura R, Hervieu, Guillaume, Dytko, George M, Foley, James J, Martin, John, Liu, Wu-Schyong, Park, Janet, Ellis, Catherine, Ganguly, Subinay, Konchar, Susan, Cluderay, Jane, Leslie, Ron, Wilson, Shelagh, Sarau, Henry M

“…The underlying causes of obesity are poorly understood but probably involve complex interactions between many neurotransmitter and neuropeptide systems…”
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Differential vasoconstrictor activity of human urotensin‐II in vascular tissue isolated from the rat, mouse, dog, pig, marmoset and cynomolgus monkey by Douglas, Stephen A, Sulpizio, Anthony C, Piercy, Valerie, Sarau, Henry M, Ames, Robert S, Aiyar, Nambi V, Ohlstein, Eliot H, Willette, Robert N

“…Urotensin‐II (U‐II) and its G‐protein‐coupled receptor, GPR14, are expressed within mammalian cardiac and peripheral vascular tissue and, as such, may regulate…”
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Molecular Cloning and Functional Characterization of MCH2, a Novel Human MCH Receptor by Hill, Jeffrey, Duckworth, Malcolm, Murdock, Paul, Rennie, Gillian, Sabido-David, Cibele, Ames, Robert S., Szekeres, Philip, Wilson, Shelagh, Bergsma, Derk J., Gloger, Israel S., Levy, Dana S., Chambers, Jon K., Muir, Alison I.

“…Melanin-concentrating hormone (MCH) is involved in the regulation of feeding and energy homeostasis. Recently, a 353-amino acid splice variant form of the…”
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A G Protein-coupled Receptor for UDP-glucose by Chambers, Jon K., Macdonald, Lynn E., Sarau, Henry M., Ames, Robert S., Freeman, Katie, Foley, James J., Zhu, Yuan, McLaughlin, Megan M., Murdock, Paul, McMillan, Lynette, Trill, John, Swift, Ann, Aiyar, Nambi, Taylor, Paul, Vawter, Lisa, Naheed, Sajda, Szekeres, Philip, Hervieu, Guillaume, Scott, Claire, Watson, Jeanette M., Murphy, Andrew J., Duzic, Emir, Klein, Christine, Bergsma, Derk J., Wilson, Shelagh, Livi, George P.

“…Uridine 5′-diphosphoglucose (UDP-glucose) has a well established biochemical role as a glycosyl donor in the enzymatic biosynthesis of carbohydrates. It is…”
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Human T Cells Express the C5a Receptor and Are Chemoattracted to C5a by Nataf, Serge, Davoust, Nathalie, Ames, Robert S, Barnum, Scott R

“…The anaphylatoxin C5a is a potent mediator of inflammation that exerts a broad range of activity on cells of the myeloid lineage. In this study, we present the…”
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Receptor for the Pain Modulatory Neuropeptides FF and AF Is an Orphan G Protein-coupled Receptor by Elshourbagy, N A, Ames, R S, Fitzgerald, L R, Foley, J J, Chambers, J K, Szekeres, P G, Evans, N A, Schmidt, D B, Buckley, P T, Dytko, G M, Murdock, P R, Milligan, G, Groarke, D A, Tan, K B, Shabon, U, Nuthulaganti, P, Wang, D Y, Wilson, S, Bergsma, D J, Sarau, H M

“…Opiate tolerance and dependence are major clinical and social problems. The anti-opiate neuropeptides FF and AF (NPFF and NPAF) have been implicated in pain…”
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Induction of sensitivity to the cytotoxic action of tumor necrosis factor alpha by adenovirus E1A is independent of transformation and transcriptional activation by Ames, R S, Holskin, B, Mitcho, M, Shalloway, D, Chen, M J

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor by Sarau, H M, Ames, R S, Chambers, J, Ellis, C, Elshourbagy, N, Foley, J J, Schmidt, D B, Muccitelli, R M, Jenkins, O, Murdock, P R, Herrity, N C, Halsey, W, Sathe, G, Muir, A I, Nuthulaganti, P, Dytko, G M, Buckley, P T, Wilson, S, Bergsma, D J, Hay, D W

“…The cysteinyl leukotrienes (CysLTs) have been implicated in the pathophysiology of inflammatory disorders, in particular asthma, for which the CysLT receptor…”
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Identification of a Selective Nonpeptide Antagonist of the Anaphylatoxin C3a Receptor That Demonstrates Antiinflammatory Activity in Animal Models by Ames, Robert S, Lee, Dennis, Foley, James J, Jurewicz, Anthony J, Tornetta, Mark A, Bautsch, Wilfried, Settmacher, Britta, Klos, Andreas, Erhard, Karl F, Cousins, Russell D, Sulpizio, Anthony C, Hieble, J. Paul, McCafferty, Gerald, Ward, Keith W, Adams, Jerry L, Bondinell, William E, Underwood, David C, Osborn, Ruth R, Badger, Alison M, Sarau, Henry M

“…The anaphylatoxin C3a is a potent chemotactic peptide and inflammatory mediator released during complement activation which binds to and activates a…”
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Isolation of a neutralizing human RSV antibody from a dominant, non- neutralizing immune repertoire by epitope-blocked panning by Ping, T, Tornetta, MA, Ames, RS, Bankosky, BC, Griego, S, Silverman, C, Porter, T, Moore, G, Sweet, RW

“…We isolated a large panel of human Abs directed against the respiratory syncytial virus (RSV) Ag from combinatorial phage display libraries. Following initial…”
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Isolation of neutralizing anti-C5a monoclonal antibodies from a filamentous phage monovalent Fab display library [published erratum appears in J Immunol 1994 Jul 15;153(2):910] by Ames, RS, Tornetta, MA, Jones, CS, Tsui, P

“…A panel of mAbs against the activated complement component C5a was obtained from a filamentous phage M13-Fab display library generated from mice immunized with…”
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Conversion of murine Fabs isolated from a combinatorial phage display library to full length immunoglobulins by Ames, Robert S., Tornetta, Mark A., Deen, Keith, Jones, Christopher S., Swift, Ann M., Ganguly, Subinay

“…The use of combinatorial Ig libraries displayed on the surface of bacteriophage has advantages over traditional hybridoma techniques for the generation of mAbs…”
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Molecular Cloning and Characterization of the Human Anaphylatoxin C3a Receptor by Ames, Robert S., Li, Yi, Sarau, Henry M., Nuthulaganti, Paru, Foley, James J., Ellis, Catherine, Zeng, Zhizhen, Su, Kui, Jurewicz, Anthony J., Hertzberg, Robert P., Bergsma, Derk J., Kumar, Chandrika

“…In a human neutrophil cDNA library, an orphan G-protein-coupled receptor, HNFAG09, with 37% nucleotide identity to the C5a receptor (C5a-R, CD88) was…”
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The human C3a receptor is expressed on neutrophils and monocytes, but not on B or T lymphocytes by Martin, U, Bock, D, Arseniev, L, Tornetta, M A, Ames, R S, Bautsch, W, Köhl, J, Ganser, A, Klos, A

“…The pathophysiological relevance of the complement split product C3a as a proinflammatory mediator is still ill defined. The expression pattern of the human…”
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Cloning, Pharmacology, and Tissue Distribution of G-Protein-Coupled Receptor GPR105 (KIAA0001) Rodent Orthologs by Freeman, Katie, Tsui, Ping, Moore, Darren, Emson, Piers C., Vawter, Lisa, Naheed, Sajda, Lane, Pamela, Bawagan, Hinayana, Herrity, Nicole, Murphy, Kay, Sarau, Henry M., Ames, Robert S., Wilson, Shelagh, Livi, George P., Chambers, Jon K.

“…It has recently been shown that UDP-glucose is a potent agonist of the orphan G-protein-coupled receptor (GPCR) KIAA0001. Here we report cloning and analysis…”
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