Search Results - "Ames, David"
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Global spread of Salmonella Enteritidis via centralized sourcing and international trade of poultry breeding stocks
Published in Nature communications (25-08-2021)“…A pandemic of Salmonella enterica serotype Enteritidis emerged in the 1980s due to contaminated poultry products. How Salmonella Enteritidis rapidly swept…”
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Dementia and caregiver burden: A three‐year longitudinal study
Published in International journal of geriatric psychiatry (01-02-2020)“…Objectives Dementia, with its progressive cognitive and functional decline and associated neuropsychiatric symptoms, places a large burden on caregivers. While…”
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The prevalence of anxiety in older adults: Methodological issues and a review of the literature
Published in Journal of affective disorders (01-08-2008)“…Abstract Background Despite the relative neglect of anxiety in older adults, the growing literature on its prevalence suggests that anxiety is highly prevalent…”
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Prevalence of Dementia 7.5 Years after Coronary Artery Bypass Graft Surgery
Published in Anesthesiology (Philadelphia) (01-07-2016)“…BACKGROUND:Although postoperative cognitive dysfunction (POCD) is well described after coronary artery bypass graft (CABG) surgery, a major concern has been…”
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Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study
Published in Lancet neurology (01-04-2013)“…Summary Background Similar to most chronic diseases, Alzheimer's disease (AD) develops slowly from a preclinical phase into a fully expressed clinical…”
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Cerebrospinal Fluid Biomarker for Alzheimer Disease Predicts Postoperative Cognitive Dysfunction
Published in Anesthesiology (Philadelphia) (01-02-2016)“…BACKGROUND:Postoperative cognitive dysfunction (POCD) affects 16 to 21% of the elderly 3 months after anesthesia and surgery and is associated with adverse…”
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Clinical and cognitive trajectories in cognitively healthy elderly individuals with suspected non-Alzheimer's disease pathophysiology (SNAP) or Alzheimer's disease pathology: a longitudinal study
Published in Lancet neurology (01-09-2016)“…Summary Background Brain amyloid β (Aβ) deposition and neurodegeneration have been documented in about 50–60% of cognitively healthy elderly individuals (aged…”
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Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer’s disease
Published in Nature communications (10-11-2020)“…Changes to lipid metabolism are tightly associated with the onset and pathology of Alzheimer’s disease (AD). Lipids are complex molecules comprising many…”
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Predictors of institutionalization in dementia: a three year longitudinal study
Published in Journal of Alzheimer's disease (01-01-2014)“…Patients with dementia often require institutionalization when they can no longer care for themselves. The study examined demographic and clinical variables…”
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Prevalence and Predictors of Burden in Caregivers of People with Dementia
Published in The American journal of geriatric psychiatry (01-08-2014)“…Objective To examine prevalence and predictors of burden in caregivers of people with dementia attending memory clinics. Methods This Prospective cohort study…”
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Amyloid imaging results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging
Published in Neurobiology of aging (01-08-2010)“…Abstract The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging, a participant of the worldwide Alzheimer's Disease Neuroimaging Initiative…”
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Cognitive impairment and vitamin B12: a review
Published in International psychogeriatrics (01-04-2012)“…This review examines the associations between low vitamin B12 levels, neurodegenerative disease, and cognitive impairment. The potential impact of…”
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Assessment of the DTI‐ALPS Parameter Along the Perivascular Space in Older Adults at Risk of Dementia
Published in Journal of neuroimaging (01-05-2021)“…ABSTRACT BACKGROUND AND PURPOSE Recently, there has been growing interest in the glymphatic system (the functional waste clearance pathway for the central…”
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The Relationship between Sleep Quality and Brain Amyloid Burden
Published in Sleep (New York, N.Y.) (01-05-2016)“…To evaluate the association between self-reported sleep quality and levels of brain β-amyloid (Aβ) burden, and to determine the effect of the apolipoprotein E…”
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Multi-cohort and longitudinal Bayesian clustering study of stage and subtype in Alzheimer’s disease
Published in Nature communications (05-08-2022)“…Understanding Alzheimer’s disease (AD) heterogeneity is important for understanding the underlying pathophysiological mechanisms of AD. However, AD atrophy…”
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Non-negative matrix factorisation improves Centiloid robustness in longitudinal studies
Published in NeuroImage (Orlando, Fla.) (01-02-2021)“…: Centiloid was introduced to harmonise β-Amyloid (Aβ) PET quantification across different tracers, scanners and analysis techniques. Unfortunately, Centiloid…”
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Comparison of MR-less PiB SUVR quantification methods
Published in Neurobiology of aging (2015)“…Abstract11 C-Pittsburgh compound B (PiB) is a positron emission tomography (PET) tracer designed to bind to amyloid-β (Aβ) plaques, one of the hallmarks of…”
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Spousal recollections of early signs of primary progressive aphasia
Published in International journal of language & communication disorders (01-03-2018)“…Background Although primary progressive aphasia (PPA) is characterized by progressive loss of language and communication skills, knowledge about the earliest…”
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Predictors of Mortality in Dementia: The PRIME Study
Published in Journal of Alzheimer's disease (23-05-2016)“…Dementia is a terminal illness. While various baseline characteristics of patients, such as age, sex, and dementia severity, are known to predict mortality,…”
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Safety, efficacy, and biomarker findings of PBT2 in targeting Aβ as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial
Published in Lancet neurology (2008)“…Summary Background PBT2 is a metal-protein attenuating compound (MPAC) that affects the Cu2+ -mediated and Zn2+ -mediated toxic oligomerisation of Aβ seen in…”
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