Search Results - "Ames, Brenda"

INX-08189, a Phosphoramidate Prodrug of 6-O-Methyl-2′-C-Methyl Guanosine, Is a Potent Inhibitor of Hepatitis C Virus Replication with Excellent Pharmacokinetic and Pharmacodynamic Properties by Vernachio, John H, Bleiman, Blair, Bryant, K Dawn, Chamberlain, Stanley, Hunley, Damound, Hutchins, Jeff, Ames, Brenda, Gorovits, Elena, Ganguly, Babita, Hall, Andrea, Kolykhalov, Alexander, Liu, Yule, Muhammad, Jerry, Raja, Nicholas, Walters, C Robin, Wang, Jin, Williams, Karen, Patti, Joseph M, Henson, Geoffrey, Madela, Karolina, Aljarah, Mohamed, Gilles, Arnaud, McGuigan, Christopher

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Anti-Clumping Factor A Immunoglobulin Reduces the Duration of Methicillin-Resistant Staphylococcus aureus Bacteremia in an Experimental Model of Infective Endocarditis by VERNACHIO, John, BAYER, Arnold S, THUAN LE, CHAI, Yin-Li, PRATER, Bradley, SCHNEIDER, Amy, AMES, Brenda, SYRIBEYS, Peter, ROBBINS, Jeffrey, PATTI, Joseph M

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Human Immunoglobulin G Recognizing Fibrinogen-Binding Surface Proteins Is Protective against both Staphylococcus aureus and Staphylococcus epidermidis Infections In Vivo by VERNACHIO, John H, BAYER, Arnold S, AMES, Brenda, BRYANT, Dawn, PRATER, Bradley D, SYRIBEYS, Peter J, GOROVITS, Elena L, PATTI, Joseph M

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SdrX, a Serine-Aspartate Repeat Protein Expressed by Staphylococcus capitis with Collagen VI Binding Activity by Liu, Yule, Ames, Brenda, Gorovits, Elena, Prater, Bradley D, Syribeys, Peter, Vernachio, John H, Patti, Joseph M

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Monoclonal antibodies recognizing the Enterococcus faecalis collagen-binding MSCRAMM Ace: Conditional expression and binding analysis by Hall, Andrea E., Gorovits, Elena L., Syribeys, Peter J., Domanski, Paul J., Ames, Brenda R., Chang, Cathy Y., Vernachio, John H., Patti, Joseph M., Hutchins, Jeff T.

“…Enterococci are opportunistic pathogens known to cause numerous clinical infections and complications in humans. Adhesin-mediated binding to extracellular…”
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Design, synthesis and evaluation of a novel double pro-drug: INX-08189. A new clinical candidate for hepatitis C virus by McGuigan, Christopher, Madela, Karolina, Aljarah, Mohamed, Gilles, Arnaud, Brancale, Andrea, Zonta, Nicola, Chamberlain, Stanley, Vernachio, John, Hutchins, Jeff, Hall, Andrea, Ames, Brenda, Gorovits, Elena, Ganguly, Babita, Kolykhalov, Alexander, Wang, Jin, Muhammad, Jerry, Patti, Joseph M., Henson, Geoffrey

“…Phosphoramidate ProTides of 2′-C-Me-6-MeOG are up to 500-fold more potent versus HCV than the 2′-C-MeG parent, being active at nanomolar levels. The lead has…”
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Phosphoramidate ProTides of 2′-C-Methylguanosine as Highly Potent Inhibitors of Hepatitis C Virus. Study of Their in Vitro and in Vivo Properties by McGuigan, Christopher, Gilles, Arnaud, Madela, Karolina, Aljarah, Mohamed, Holl, Sabrina, Jones, Sarah, Vernachio, John, Hutchins, Jeff, Ames, Brenda, Bryant, K. Dawn, Gorovits, Elena, Ganguly, Babita, Hunley, Damound, Hall, Andrea, Kolykhalov, Alexander, Liu, Yule, Muhammad, Jerry, Raja, Nicholas, Walters, Robin, Wang, Jin, Chamberlain, Stanley, Henson, Geoffrey

“…Hepatitis C virus infection constitutes a serious health problem in need of more effective therapies. Nucleoside analogues with improved exposure, efficacy,…”
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