Search Results - "Amerik, Alexander Yu"

Chalcone-based small-molecule inhibitors attenuate malignant phenotype via targeting deubiquitinating enzymes by Issaenko, Olga A., Amerik, Alexander Yu

“…The ubiquitin-proteasome system (UPS) is usurped by many if not all cancers to regulate their survival, proliferation, invasion, angiogenesis and metastasis…”
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Erratum to Issaenko OA, et al. Cell Cycle Volume 11, Issue 9; pp. 1804-17 by Issaenko, Olga A., Amerik, Alexander Yu

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The Saccharomyces cerevisiae ubiquitin–proteasome system by Hochstrasser, M., Johnson, P. R., Arendt, C. S., Amerik, A. Y., Swaminathan, S., Swanson, R., Li, S., Laney, J., Pals-Rylaarsdam, R., Nowak, J., Connerly, P. L.

“…1 homeodomain proteins. The data suggest that degradation signals may overlap protein–protein interaction surfaces, allowing a straightforward steric mechanism…”
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In vivo disassembly of free polyubiquitin chains by yeast Ubp14 modulates rates of protein degradation by the proteasome by Amerik, A.Yu, Swaminathan, S, Krantz, B.A, Wilkinson, K.D, Hochstrasser, M

“…Degradation of many eukaryotic proteins requires their prior ligation to polyubiquitin chains, which target substrates to the 26S proteasome, an abundant…”
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Site-directed mutagenesis of La protease: A catalytically active serine residue by Amerik, Alexander Yu, Antonov, Vladimir K., Gorbalenya, Alexander E., Kotova, Svetlana A., Rotanova, Tatyana V., Shimbarevich, Elena V.

“…Comparative sequence analysis of Escherichia coli ATP-dependent La protease led to the suggestion that Ser 679 is the catalytically active enzyme residue…”
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Cloning and sequence analysis of cDNA for a human homolog of eubacterial ATP-dependent Lon proteases by Amerik, Alexander Yu, Petukhova, Galina V., Grigorenko, Vitaly G., Lykov, Igor P., Yarovoi, Serge V., Lipkin, Valery M., Gorbalenya, Alexander E.

“…Overlapping cDNA clones containing mRNA for a putative Lon protease (LonHS) were isolated from cDNA libraries prepared from human brain poly(A) + RNA. The…”
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HIV-I protease. Cloning, expression, and purification by Dergousova, N I, Amerik AYu, Volynskaya, A M, Rumsh, L D

“…A new method for obtaining HIV-I protease was suggested. Fusion proteins composed of the N-terminal fragment of human gamma-interferon and HIV-I protease…”
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Cloning of cDNA for granzyme-like protein III, a novel serine proteinase from rat duodenum by Grigorenko, Vitaly G., Yarovoi, Serge V., Paulauskaite, Ramune, Amerik, Alexander Yu

“…We previously reported cloning of cDNAs which encode two granzyme-like serine proteinases (GLP I and GLP II) from rat duodenum. In this paper we present the…”
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Identification, sequence analysis, and characterization of cDNA clones encoding two granzyme-like serine proteinases from rat duodenum by Amerik, Alexander Yu, Yarovoi, Serge V., Grigorenko, Vitali G., Antonov, Vladimir K.

“…Clones of cDNA encoding two serine proteinases were isolated from a cDNA library prepared from rat duodenum mRNA. The deduced amino acid sequences consisted of…”
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Site‐directed mutagenesis of La protease by Amerik, Alexander Yu, Antonov, Vladimir K., Gorbalenya, Alexander E., Kotova, Svetlana A., Rotanova, Tatyana V., Shimbarevich, Elena V.

“…Comparative sequence analysis of Escherichia coli ATP‐dependent La protease led to the suggestion that Ser679 is the catalytically active enzyme residue…”
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