Search Results - "Americo, Jeffrey"

Virulence differences of mpox (monkeypox) virus clades I, IIa, and IIb.1 in a small animal model by Americo, Jeffrey L, Earl, Patricia L, Moss, Bernard

“…Human mpox (monkeypox), a disease with similarities to smallpox, is endemic in Africa where it has persisted as a zoonosis with limited human-to-human spread…”
Get full text

Natural killer cells expanded in vivo or ex vivo with IL-15 overcomes the inherent susceptibility of CAST mice to lethal infection with orthopoxviruses by Earl, Patricia L, Americo, Jeffrey L, Moss, Bernard

“…The wild-derived inbred CAST/EiJ mouse, one of eight founder strains in the Collaborative Cross panel, is an exceptional model for studying monkeypox virus…”
Get full text

Intranasal inoculation of an MVA-based vaccine induces IgA and protects the respiratory tract of hACE2 mice from SARS-CoV-2 infection by Americo, Jeffrey L, Cotter, Catherine A, Earl, Patricia L, Liu, Ruikang, Moss, Bernard

“…Current vaccines have greatly diminished the severity of the COVID-19 pandemic, even though they do not entirely prevent infection and transmission, likely due…”
Get full text

One or two injections of MVA-vectored vaccine shields hACE2 transgenic mice from SARS-CoV-2 upper and lower respiratory tract infection by Liu, Ruikang, Americo, Jeffrey L., Cotter, Catherine A., Earl, Patricia L., Erez, Noam, Peng, Chen, Moss, Bernard

“…Modified vaccinia virus Ankara (MVA) is a replication-restricted smallpox vaccine, and numerous clinical studies of recombinant MVAs (rMVAs) as vectors for…”
Get full text

Retrograde Transport from Early Endosomes to the trans-Golgi Network Enables Membrane Wrapping and Egress of Vaccinia Virus Virions by Sivan, Gilad, Weisberg, Andrea S, Americo, Jeffrey L, Moss, Bernard

“…The anterograde pathway, from the endoplasmic reticulum through the trans-Golgi network to the cell surface, is utilized by trans-membrane and secretory…”
Get full text

Insufficient Innate Immunity Contributes to the Susceptibility of the Castaneous Mouse to Orthopoxvirus Infection by Earl, Patricia L, Americo, Jeffrey L, Moss, Bernard

“…The castaneous (CAST) mouse, a wild-derived inbred strain, is highly susceptible to orthopoxvirus infection by intranasal and systemic routes. The 50% lethal…”
Get full text

Spontaneous and Targeted Mutations in the Decapping Enzyme Enhance Replication of Modified Vaccinia Virus Ankara (MVA) in Monkey Cells by Erez, Noam, Wyatt, Linda S, Americo, Jeffrey L, Xiao, Wei, Moss, Bernard

“…Modified vaccinia virus Ankara (MVA) was derived by repeated passaging in chick fibroblasts, during which deletions and mutations rendered the virus unable to…”
Get full text

Lymph node conduits transport virions for rapid T cell activation by Reynoso, Glennys V., Weisberg, Andrea S., Shannon, John P., McManus, Daniel T., Shores, Lucas, Americo, Jeffrey L., Stan, Radu V., Yewdell, Jonathan W., Hickman, Heather D.

“…Despite intense interest in antiviral T cell priming, the routes by which virions move in lymph nodes (LNs) are imperfectly understood. Current models fail to…”
Get full text

Droplet digital PCR for rapid enumeration of viral genomes and particles from cells and animals infected with orthopoxviruses by Americo, Jeffrey L., Earl, Patricia L., Moss, Bernard

“…Droplet digital polymerase chain reaction (ddPCR) was adapted for quantifying the number of orthopoxviral genomes in purified virus samples, infected cell…”
Get full text

Lethal Monkeypox Virus Infection of CAST/EiJ Mice Is Associated with a Deficient Gamma Interferon Response by EARL, Patricia L, AMERICO, Jeffrey L, MOSS, Bernard

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Human Host Range Restriction of the Vaccinia Virus C7/K1 Double Deletion Mutant Is Mediated by an Atypical Mode of Translation Inhibition by Sivan, Gilad, Glushakow-Smith, Shira G, Katsafanas, George C, Americo, Jeffrey L, Moss, Bernard

“…Replication of vaccinia virus in human cells depends on the viral C7 or K1 protein. A previous human genome-wide short interfering RNA (siRNA) screen with a…”
Get full text

Loss of the vaccinia virus 35-amino acid hydrophobic O3 protein is partially compensated by mutations in the transmembrane domains of other entry proteins by Tak, Andrew I, Americo, Jeffrey L, Diesterbeck, Ulrike S, Moss, Bernard

“…Eleven highly conserved proteins comprise the poxvirus entry-fusion complex (EFC). We focused on vaccinia virus (VACV) O3, a 35-amino acid, largely hydrophobic…”
Get full text

An mpox virus mRNA-lipid nanoparticle vaccine confers protection against lethal orthopoxviral challenge by Freyn, Alec W, Atyeo, Caroline, Earl, Patricia L, Americo, Jeffrey L, Chuang, Gwo-Yu, Natarajan, Harini, Frey, Tiffany R, Gall, Jason G, Moliva, Juan I, Hunegnaw, Ruth, Asthagiri Arunkumar, Guha, Ogega, Clinton O, Nasir, Arshan, Santos, Genesis, Levin, Rafael H, Meni, Anusha, Jorquera, Patricia A, Bennett, Hamilton, Johnson, Joshua A, Durney, Michael A, Stewart-Jones, Guillaume, Hooper, Jay W, Colpitts, Tonya M, Alter, Galit, Sullivan, Nancy J, Carfi, Andrea, Moss, Bernard

“…Mpox virus (MPXV) caused a global outbreak in 2022. Although smallpox vaccines were rapidly deployed to curb spread and disease among those at highest risk,…”
Get more information

Identification of Wild-Derived Inbred Mouse Strains Highly Susceptible to Monkeypox Virus Infection for Use as Small Animal Models by Americo, Jeffrey L, Moss, Bernard, Earl, Patricia L

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Interferon α/β Decoy Receptor Encoded by a Variant in the Dryvax Smallpox Vaccine Contributes to Virulence and Correlates with Severe Vaccine Side Effects by Liu, Ruikang, Americo, Jeffrey L, Earl, Patricia L, Villani, Jack, Cotter, Catherine A, Moss, Bernard

“…Although providing long-lasting immunity, smallpox vaccination was associated with local and systemic reactions and rarely with severe complications, including…”
Get full text

Comparative live bioluminescence imaging of monkeypox virus dissemination in a wild-derived inbred mouse ( Mus musculus castaneus) and outbred African dormouse ( Graphiurus kelleni ) by Earl, Patricia L, Americo, Jeffrey L, Cotter, Catherine A, Moss, Bernard

“…Abstract Monkeypox virus belongs to the orthopoxvirus genus, infects rodents and monkeys in Africa, produces a smallpox-like zoonotic disease in humans, and…”
Get full text

Genetic studies of the susceptibility of classical and wild-derived inbred mouse strains to monkeypox virus by Earl, Patricia L, Americo, Jeffrey L, Moss, Bernard

“…Abstract Previously, we screened 38 inbred mouse strains for susceptibility to monkeypox virus (MPXV) and focused on wild-derived CAST mice because of their…”
Get full text

Protection from SARS-CoV-2 Variants by MVAs expressing matched or mismatched S administered intranasally to mice by Cotter, Catherine A., Americo, Jeffrey L., Earl, Patricia L., Moss, Bernard

“…SARS-CoV-2 vaccines prevent severe disease but are less efficient in averting infection and transmission of variant strains, making it imperative to explore…”
Get full text

Growth and Purification of Vaccinia Virus Stocks for MPM Imaging by Reynoso, Glennys V, Shannon, John P, Americo, Jeffrey L, Gibbs, James, Hickman, Heather D

“…This chapter provides methods for the propagation, purification, and titration of vaccinia virus (VACV) and the highly attenuated strain-modified vaccinia…”
Get more information

Novel Nonreplicating Vaccinia Virus Vector Enhances Expression of Heterologous Genes and Suppresses Synthesis of Endogenous Viral Proteins by Wyatt, Linda S, Xiao, Wei, Americo, Jeffrey L, Earl, Patricia L, Moss, Bernard

“…Viruses are used as expression vectors for protein synthesis, immunology research, vaccines, and therapeutics. Advantages of poxvirus vectors include the…”
Get full text