Search Results - "American journal of physiology. Lung cellular and molecular physiology"

Healing after COVID-19: are survivors at risk for pulmonary fibrosis? by McDonald, Lindsay T

“…The novel SARS-CoV-2 coronavirus, which is responsible for COVID-19 disease, was first reported in Wuhan, China, in December of 2019. The virus rapidly spread,…”
Get more information

Estrogen regulates the expression of SARS-CoV-2 receptor ACE2 in differentiated airway epithelial cells by Stelzig, Kimberly E, Canepa-Escaro, Fabrizio, Schiliro, Marta, Berdnikovs, Sergejs, Prakash, Y S, Chiarella, Sergio E

“…There is marked sexual dimorphism in the current coronavirus disease 2019 (COVID-19) pandemic. Here we report that estrogen can regulate the expression of…”
Get more information

Heparin as a therapy for COVID-19: current evidence and future possibilities by Hippensteel, Joseph A, LaRiviere, Wells B, Colbert, James F, Langouët-Astrié, Christophe J, Schmidt, Eric P

“…Coronavirus disease 2019 (COVID-19), the clinical syndrome associated with infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has…”
Get more information

Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis by Liu, Fei, Lagares, David, Choi, Kyoung Moo, Stopfer, Lauren, Marinković, Aleksandar, Vrbanac, Vladimir, Probst, Clemens K, Hiemer, Samantha E, Sisson, Thomas H, Horowitz, Jeffrey C, Rosas, Ivan O, Fredenburgh, Laura E, Feghali-Bostwick, Carol, Varelas, Xaralabos, Tager, Andrew M, Tschumperlin, Daniel J

“…Pathological fibrosis is driven by a feedback loop in which the fibrotic extracellular matrix is both a cause and consequence of fibroblast activation…”
Get more information

IPF lung fibroblasts have a senescent phenotype by Álvarez, Diana, Cárdenes, Nayra, Sellarés, Jacobo, Bueno, Marta, Corey, Catherine, Hanumanthu, Vidya Sagar, Peng, Yating, D'Cunha, Hannah, Sembrat, John, Nouraie, Mehdi, Shanker, Swaroop, Caufield, Chandler, Shiva, Sruti, Armanios, Mary, Mora, Ana L, Rojas, Mauricio

“…The mechanisms of aging that are involved in the development of idiopathic pulmonary fibrosis (IPF) are still unclear. Although it has been hypothesized that…”
Get more information

Enrichment of selective miRNAs in exosomes and delivery of exosomal miRNAs in vitro and in vivo by Zhang, Duo, Lee, Heedoo, Zhu, Ziwen, Minhas, Jasleen K, Jin, Yang

“…Exosomes are nanovesicles secreted by cells and contain various molecules including protein, lipid, and DNA/RNA. They are crucial mediators of the…”
Get more information

Diverse macrophage populations mediate acute lung inflammation and resolution by Aggarwal, Neil R, King, Landon S, D'Alessio, Franco R

“…Acute respiratory distress syndrome (ARDS) is a devastating disease with distinct pathological stages. Fundamental to ARDS is the acute onset of lung…”
Get more information

First contact: the role of respiratory cilia in host-pathogen interactions in the airways by Kuek, Li Eon, Lee, Robert J

“…Respiratory cilia are the driving force of the mucociliary escalator, working in conjunction with secreted airway mucus to clear inhaled debris and pathogens…”
Get more information

Profibrotic effect of IL-17A and elevated IL-17RA in idiopathic pulmonary fibrosis and rheumatoid arthritis-associated lung disease support a direct role for IL-17A/IL-17RA in human fibrotic interstitial lung disease by Zhang, Jie, Wang, Dan, Wang, Lei, Wang, Shaohua, Roden, Anja C, Zhao, Hao, Li, Xiujuan, Prakash, Y S, Matteson, Eric L, Tschumperlin, Daniel J, Vassallo, Robert

“…Interleukin (IL)-17 is a T helper 17 cytokine implicated in the pathogenesis of many autoimmune diseases, including rheumatoid arthritis (RA). Although IL-17A…”
Get more information

LungMAP: The Molecular Atlas of Lung Development Program by Ardini-Poleske, Maryanne E, Clark, Robert F, Ansong, Charles, Carson, James P, Corley, Richard A, Deutsch, Gail H, Hagood, James S, Kaminski, Naftali, Mariani, Thomas J, Potter, Steven S, Pryhuber, Gloria S, Warburton, David, Whitsett, Jeffrey A, Palmer, Scott M, Ambalavanan, Namasivayam

“…The National Heart, Lung, and Blood Institute is funding an effort to create a molecular atlas of the developing lung (LungMAP) to serve as a research resource…”
Get more information

Recent advances in our understanding of the mechanisms of lung alveolarization and bronchopulmonary dysplasia by Lignelli, Ettore, Palumbo, Francesco, Myti, Despoina, Morty, Rory E

“…Bronchopulmonary dysplasia (BPD) is the most common cause of morbidity and mortality in preterm infants. A key histopathological feature of BPD is stunted late…”
Get more information

E-cigarette use results in suppression of immune and inflammatory-response genes in nasal epithelial cells similar to cigarette smoke by Martin, Elizabeth M, Clapp, Phillip W, Rebuli, Meghan E, Pawlak, Erica A, Glista-Baker, Ellen, Benowitz, Neal L, Fry, Rebecca C, Jaspers, Ilona

“…Exposure to cigarette smoke is known to result in impaired host defense responses and immune suppressive effects. However, the effects of new and emerging…”
Get more information

IL-17 in the lung: the good, the bad, and the ugly by Gurczynski, Stephen J, Moore, Bethany B

“…The IL-17 family of cytokines has emerged over the last two decades as a pleiotropic group of molecules that function in a wide variety of both beneficial and…”
Get more information

Role of apoptosis and autophagy in tuberculosis by Lam, Adam, Prabhu, Rohan, Gross, Christine M, Riesenberg, Lee Ann, Singh, Vinodkumar, Aggarwal, Saurabh

“…Tuberculosis (TB) is one of the oldest known human diseases and is transmitted by the bacteria (Mtb). TB has a rich history with evidence of TB infections…”
Get more information

Fibroblast senescence in the pathology of idiopathic pulmonary fibrosis by Waters, David W, Blokland, Kaj E C, Pathinayake, Prabuddha S, Burgess, Janette K, Mutsaers, Steven E, Prele, Cecilia M, Schuliga, Michael, Grainge, Christopher L, Knight, Darryl A

“…Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing interstitial pneumonia of unknown cause with a median survival of only three years. Little is known…”
Get more information

Activation of the mTORC1/PGC-1 axis promotes mitochondrial biogenesis and induces cellular senescence in the lung epithelium by Summer, Ross, Shaghaghi, Hoora, Schriner, DeLeila, Roque, Willy, Sales, Dominic, Cuevas-Mora, Karina, Desai, Vilas, Bhushan, Alok, Ramirez, Maria I, Romero, Freddy

“…Cellular senescence is a biological process by which cells lose their capacity to proliferate yet remain metabolically active. Although originally considered a…”
Get more information

The mercurial nature of neutrophils: still an enigma in ARDS? by Williams, Andrew E, Chambers, Rachel C

“…The acute respiratory distress syndrome (ARDS) is a life-threatening lung condition resulting from direct and indirect insults to the lung. It is characterized…”
Get more information

Mitochondrial transplantation enhances murine lung viability and recovery after ischemia-reperfusion injury by Moskowitzova, Kamila, Orfany, Arzoo, Liu, Kaifeng, Ramirez-Barbieri, Giovanna, Thedsanamoorthy, Jerusha K, Yao, Rouan, Guariento, Alvise, Doulamis, Ilias P, Blitzer, David, Shin, Borami, Snay, Erin R, Inkster, James A H, Iken, Khadija, Packard, Alan B, Cowan, Douglas B, Visner, Gary A, Del Nido, Pedro J, McCully, James D

“…The most common cause of acute lung injury is ischemia-reperfusion injury (IRI), during which mitochondrial damage occurs. We have previously demonstrated that…”
Get more information

An ex vivo model to induce early fibrosis-like changes in human precision-cut lung slices by Alsafadi, Hani N, Staab-Weijnitz, Claudia A, Lehmann, Mareike, Lindner, Michael, Peschel, Britta, Königshoff, Melanie, Wagner, Darcy E

“…Idiopathic pulmonary fibrosis (IPF) is a devastating chronic interstitial lung disease (ILD) characterized by lung tissue scarring and high morbidity. Lung…”
Get more information

Protective effect of suppressing STAT3 activity in LPS-induced acute lung injury by Zhao, Jiping, Yu, Hao, Liu, Yudong, Gibson, Sara A, Yan, Zhaoqi, Xu, Xin, Gaggar, Amit, Li, Pui-Kai, Li, Chenglong, Wei, Shi, Benveniste, Etty N, Qin, Hongwei

“…Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are diseases with high mortality. Macrophages and neutrophils are responsible for…”
Get more information