Search Results - "Amer, Mahetab H"

The effect of injection using narrow-bore needles on mammalian cells: administration and formulation considerations for cell therapies by Amer, Mahetab H., White, Lisa J., Shakesheff, Kevin M.

“…Objectives This study focuses on the effect of the injection administration process on a range of cell characteristics. Methods Effects of different ejection…”
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Translational considerations in injectable cell-based therapeutics for neurological applications: concepts, progress and challenges by Amer, Mahetab H., Rose, Felicity R. A. J., Shakesheff, Kevin M., Modo, Michel, White, Lisa J.

“…Significant progress has been made during the past decade towards the clinical adoption of cell-based therapeutics. However, existing cell-delivery approaches…”
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A biomaterials approach to influence stem cell fate in injectable cell-based therapies by Amer, Mahetab H, Rose, Felicity R A J, Shakesheff, Kevin M, White, Lisa J

“…Numerous stem cell therapies use injection-based administration to deliver high-density cell preparations. However, cell retention rates as low as 1% have been…”
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Embracing Mechanobiology in Next Generation Organ-On-A-Chip Models of Bone Metastasis by Slay, Ellen E, Meldrum, Fiona C, Pensabene, Virginia, Amer, Mahetab H

“…Bone metastasis in breast cancer is associated with high mortality. Biomechanical cues presented by the extracellular matrix play a vital role in driving…”
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From mesenchymal niches to engineered in vitro model systems: Exploring and exploiting biomechanical regulation of vertebrate hedgehog signalling by Ghuloum, Fatmah I., Johnson, Colin A., Riobo-Del Galdo, Natalia A., Amer, Mahetab H.

“…Tissue patterning is the result of complex interactions between transcriptional programs and various mechanical cues that modulate cell behaviour and drive…”
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A Detailed Assessment of Varying Ejection Rate on Delivery Efficiency of Mesenchymal Stem Cells Using Narrow‐Bore Needles by Amer, Mahetab H., Rose, Felicity R.A.J., White, Lisa J., Shakesheff, Kevin M.

“…As the number of clinical trials exploring cell therapy rises, a thorough understanding of the limits of cell delivery is essential. We used an extensive…”
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Discovery of synergistic material-topography combinations to achieve immunomodulatory osteoinductive biomaterials using a novel in vitro screening method: The ChemoTopoChip by Burroughs, Laurence, Amer, Mahetab H., Vassey, Matthew, Koch, Britta, Figueredo, Grazziela P., Mukonoweshuro, Blessing, Mikulskis, Paulius, Vasilevich, Aliaksei, Vermeulen, Steven, Dryden, Ian L., Winkler, David A., Ghaemmaghami, Amir M., Rose, Felicity R.A.J., de Boer, Jan, Alexander, Morgan R.

“…Human mesenchymal stem cells (hMSCs) are widely represented in regenerative medicine clinical strategies due to their compatibility with autologous…”
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Designing topographically textured microparticles for induction and modulation of osteogenesis in mesenchymal stem cell engineering by Amer, Mahetab H., Alvarez-Paino, Marta, McLaren, Jane, Pappalardo, Francesco, Trujillo, Sara, Wong, Jing Qian, Shrestha, Sumana, Abdelrazig, Salah, Stevens, Lee A., Lee, Jong Bong, Kim, Dong-Hyun, González-García, Cristina, Needham, David, Salmerón-Sánchez, Manuel, Shakesheff, Kevin M., Alexander, Morgan R., Alexander, Cameron, Rose, Felicity RAJ

“…Mesenchymal stem cells are the focus of intense research in bone development and regeneration. The potential of microparticles as modulating moieties of…”
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Bioactivity and anthocyanin content of microwave-assisted subcritical water extracts of Manipur black rice (Chakhao) bran and straw by Moirangthem, Kamaljit, Ramakrishna, Priya, Amer, Mahetab H., Tucker, Gregory A.

“…Chakhao, the Geographical Indication (GI) tagged aromatic black rice of Manipur, India, is a rich source of bioactive compounds such as anthocyanins. However,…”
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Genetically-programmed, mesenchymal stromal cell-laden & mechanically strong 3D bioprinted scaffolds for bone repair by Abu Awwad, Hosam Al-Deen M., Thiagarajan, Lalitha, Kanczler, Janos M., Amer, Mahetab H., Bruce, Gordon, Lanham, Stuart, Rumney, Robin M.H., Oreffo, Richard O.C., Dixon, James E.

“…Additive manufacturing processes used to create regenerative bone tissue engineered implants are not biocompatible, thereby restricting direct use with stem…”
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Polymer Microparticles with Defined Surface Chemistry and Topography Mediate the Formation of Stem Cell Aggregates and Cardiomyocyte Function by Alvarez-Paino, Marta, Amer, Mahetab H, Nasir, Aishah, Cuzzucoli Crucitti, Valentina, Thorpe, Jordan, Burroughs, Laurence, Needham, David, Denning, Chris, Alexander, Morgan R, Alexander, Cameron, Rose, Felicity R. A. J

“…Surface-functionalized microparticles are relevant to fields spanning engineering and biomedicine, with uses ranging from cell culture to advanced cell…”
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A thermoresponsive three-dimensional fibrous cell culture platform for enzyme-free expansion of mammalian cells by Aladdad, Afnan M., Amer, Mahetab H., Sidney, Laura, Hopkinson, Andrew, White, Lisa J., Alexander, Cameron, Rose, Felicity R.A.J.

“…[Display omitted] A three-dimensional thermoresponsive fibrous scaffold system for the subsequent extended culture and enzyme-free passaging of a range of…”
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Bioinspired Precision Engineering of Three‐Dimensional Epithelial Stem Cell Microniches by Prina, Elisabetta, Amer, Mahetab H., Sidney, Laura, Tromayer, Maximilian, Moore, Jonathan, Liska, Robert, Bertolin, Marina, Ferrari, Stefano, Hopkinson, Andrew, Dua, Harminder, Yang, Jing, Wildman, Ricky, Rose, Felicity R. A. J.

“…Maintenance of the epithelium relies on stem cells residing within specialized microenvironments, known as epithelial crypts. Two‐photon polymerization (2PP)…”
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Bioguided isolation of pentacyclic triterpenes from the leaves of Alstonia scholaris (Linn.) R. Br. growing in Egypt by El-Askary, Hesham I., El-Olemy, Mahmoud M., Salama, Maha M., Sleem, Amany A., Amer, Mahetab H.

“…Ethanolic and aqueous extracts of the leaves and flowers of Alstonia scholaris were evaluated for their antioxidant activity by investigating their effect on…”
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Development and Validation of a High-Performance Liquid Chromatography Method for Standardization of the Bioactive Ethyl Acetate Fraction of Alstonia scholaris (Linn.) R. Br. Growing in Egypt by El-Askary, Hesham I., El-Olemy, Mahmoud M., Salama, Maha M., Amer, Mahetab H.

“…Bio-guided fractionation of the ethanolic extract of the leaves of Alstonia scholaris (Apocynaceae) growing in Egypt was carried out to evaluate its…”
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Development of injectable cell delivery systems for high accuracy cell therapy applications by Amer, Mahetab H

“…Cell-based therapeutic interventions are being developed for a variety of clinical indications, including irreversible retinal pathologies and stroke. Numerous…”
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Development and Validation of a High-Performance Liquid Chromatography Method for Standardization of the Bioactive Ethyl Acetate Fraction of Alstonia scholaris (Linn.) R. Br. Growing in Egypt by El-Askary, Hesham I., El-Olemy, Mahmoud M., Salama, Maha M., Amer, Mahetab H.

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