Search Results - "Amer, Amal O."

Factors Mediating Environmental Biofilm Formation by Legionella pneumophila by Abu Khweek, Arwa, Amer, Amal O

“…( ) is an opportunistic waterborne pathogen and the causative agent for Legionnaires' disease, which is transmitted to humans via inhalation of contaminated…”
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Sequential ubiquitination of NLRP3 by RNF125 and Cbl-b limits inflammasome activation and endotoxemia by Tang, Juan, Tu, Sha, Lin, Guoxin, Guo, Hui, Yan, Chengkai, Liu, Qingjun, Huang, Ling, Tang, Na, Xiao, Yizhi, Pope, R Marshall, Rajaram, Murugesan V S, Amer, Amal O, Ahmer, Brian M, Gunn, John S, Wozniak, Daniel J, Tao, Lijian, Coppola, Vincenzo, Zhang, Liwen, Langdon, Wallace Y, Torrelles, Jordi B, Lipkowitz, Stanley, Zhang, Jian

“…Aberrant NLRP3 inflammasome activation contributes to the development of endotoxemia. The importance of negative regulation of NLRP3 inflammasomes remains…”
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Inflammasome-dependent release of the alarmin HMGB1 in endotoxemia by Lamkanfi, Mohamed, Sarkar, Anasuya, Vande Walle, Lieselotte, Vitari, Alberto C, Amer, Amal O, Wewers, Mark D, Tracey, Kevin J, Kanneganti, Thirumala-Devi, Dixit, Vishva M

“…Endotoxin administration recapitulates many of the host responses to sepsis. Inhibitors of the cysteine protease caspase 1 have long been sought as a…”
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Insights Into Mucosal Innate Immune Responses in House Dust Mite-Mediated Allergic Asthma by Abu Khweek, Arwa, Kim, Eunsoo, Joldrichsen, Marisa R, Amer, Amal O, Boyaka, Prosper N

“…The prevalence of asthma has been rising steadily for several decades, and continues to be a major public health and global economic burden due to both direct…”
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Checks and Balances between Autophagy and Inflammasomes during Infection by Seveau, Stephanie, Turner, Joanne, Gavrilin, Mikhail A., Torrelles, Jordi B., Hall-Stoodley, Luanne, Yount, Jacob S., Amer, Amal O.

“…Autophagy and inflammasome complex assembly are physiological processes that control homeostasis, inflammation, and immunity. Autophagy is a ubiquitous pathway…”
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Caspase-11 Promotes the Fusion of Phagosomes Harboring Pathogenic Bacteria with Lysosomes by Modulating Actin Polymerization by Akhter, Anwari, Caution, Kyle, Abu Khweek, Arwa, Tazi, Mia, Abdulrahman, Basant A., Abdelaziz, Dalia H.A., Voss, Oliver H., Doseff, Andrea I., Hassan, Hoda, Azad, Abul K., Schlesinger, Larry S., Wewers, Mark D., Gavrilin, Mikhail A., Amer, Amal O.

“…Inflammasomes are multiprotein complexes that include members of the NLR (nucleotide-binding domain leucine-rich repeat containing) family and caspase-1. Once…”
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IFN-γ stimulates autophagy-mediated clearance of Burkholderia cenocepacia in human cystic fibrosis macrophages by Assani, Kaivon, Tazi, Mia F, Amer, Amal O, Kopp, Benjamin T

“…Burkholderia cenocepacia is a virulent pathogen that causes significant morbidity and mortality in patients with cystic fibrosis (CF), survives intracellularly…”
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Caspase-11 Mediates Neutrophil Chemotaxis and Extracellular Trap Formation During Acute Gouty Arthritis Through Alteration of Cofilin Phosphorylation by Caution, Kyle, Young, Nicholas, Robledo-Avila, Frank, Krause, Kathrin, Abu Khweek, Arwa, Hamilton, Kaitlin, Badr, Asmaa, Vaidya, Anup, Daily, Kylene, Gosu, Hawin, Anne, Midhun N K, Eltobgy, Mostafa, Dakhlallah, Duaa, Argwal, Sudha, Estfanous, Shady, Zhang, Xiaoli, Partida-Sanchez, Santiago, Gavrilin, Mikhail A, Jarjour, Wael N, Amer, Amal O

“…Gout is characterized by attacks of arthritis with hyperuricemia and monosodium urate (MSU) crystal-induced inflammation within joints. Innate immune responses…”
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Cysteamine-mediated clearance of antibiotic-resistant pathogens in human cystic fibrosis macrophages by Shrestha, Chandra L, Assani, Kaivon D, Rinehardt, Hannah, Albastroiu, Florentina, Zhang, Shuzhong, Shell, Richard, Amer, Amal O, Schlesinger, Larry S, Kopp, Benjamin T

“…Members of the Burkholderia cepacia complex are virulent, multi-drug resistant pathogens that survive and replicate intracellularly in patients with cystic…”
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Gasdermin D promotes influenza virus-induced mortality through neutrophil amplification of inflammation by Speaks, Samuel, McFadden, Matthew I., Zani, Ashley, Solstad, Abigail, Leumi, Steve, Roettger, Jack E., Kenney, Adam D., Bone, Hannah, Zhang, Lizhi, Denz, Parker J., Eddy, Adrian C., Amer, Amal O., Robinson, Richard T., Cai, Chuanxi, Ma, Jianjie, Hemann, Emily A., Forero, Adriana, Yount, Jacob S.

“…Influenza virus activates cellular inflammasome pathways, which can be both beneficial and detrimental to infection outcomes. Here, we investigate the function…”
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Physical activity prevents acute inflammation in a gout model by downregulation of TLR2 on circulating neutrophils as well as inhibition of serum CXCL1 and is associated with decreased pain and inflammation in gout patients by Jablonski, Kyle, Young, Nicholas A, Henry, Caitlin, Caution, Kyle, Kalyanasundaram, Anuradha, Okafor, Ifeoma, Harb, Peter, Schwarz, Emmy, Consiglio, Paul, Cirimotich, Chris M, Bratasz, Anna, Sarkar, Anasuya, Amer, Amal O, Jarjour, Wael N, Schlesinger, Naomi

“…Gout is the most prevalent inflammatory arthritis. To study the effects of regular physical activity and exercise intensity on inflammation and clinical…”
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Elevated Expression of MiR-17 in Microglia of Alzheimer's Disease Patients Abrogates Autophagy-Mediated Amyloid-β Degradation by Estfanous, Shady, Daily, Kylene P, Eltobgy, Mostafa, Deems, Nicholas P, Anne, Midhun N K, Krause, Kathrin, Badr, Asmaa, Hamilton, Kaitlin, Carafice, Cierra, Hegazi, Ahmad, Abu Khweek, Arwa, Kelani, Hesham, Nimjee, Shahid, Awad, Hamdy, Zhang, Xiaoli, Cormet-Boyaka, Estelle, Haffez, Hesham, Soror, Sameh, Mikhail, Adel, Nuovo, Gerard, Barrientos, Ruth M, Gavrilin, Mikhail A, Amer, Amal O

“…Autophagy is a proposed route of amyloid-β (Aβ) clearance by microglia that is halted in Alzheimer's Disease (AD), though mechanisms underlying this…”
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The Sphingosine-1-Phosphate Lyase (LegS2) Contributes to the Restriction of Legionella pneumophila in Murine Macrophages by Abu Khweek, Arwa, Kanneganti, Apurva, Guttridge D, Denis C, Amer, Amal O

“…L. pneumophila is the causative agent of Legionnaires' disease, a human illness characterized by severe pneumonia. In contrast to those derived from humans,…”
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TLR2 and RIP2 Pathways Mediate Autophagy of Listeria monocytogenes via Extracellular Signal-regulated Kinase (ERK) Activation by Anand, Paras K., Tait, Stephen W.G., Lamkanfi, Mohamed, Amer, Amal O., Nunez, Gabriel, Pagès, Gilles, Pouysségur, Jacques, McGargill, Maureen A., Green, Douglas R., Kanneganti, Thirumala-Devi

“…Listeria monocytogenes is a facultative intracellular pathogen that invades both phagocytic and non-phagocytic cells. Recent studies have shown that L…”
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Structural stability of Burkholderia cenocepacia biofilms is reliant on eDNA structure and presence of a bacterial nucleic acid binding protein by Novotny, Laura A, Amer, Amal O, Brockson, M Elizabeth, Goodman, Steven D, Bakaletz, Lauren O

“…Cystic fibrosis (CF) is the most common lethal inherited genetic disorder affection Caucasians. Even with medical advances, CF is life-shortening with patients…”
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Autophagy is an immediate macrophage response to Legionella pneumophila by Amer, Amal O., Swanson, Michele S.

“…Summary After ingestion by macrophages, Legionella pneumophila enter spacious vacuoles that are quickly enveloped by endoplasmic reticulum (ER), then slowly…”
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Autophagy stimulation by rapamycin suppresses lung inflammation and infection by Burkholderia cenocepacia in a model of cystic fibrosis by Abdulrahman, Basant A., Khweek, Arwa Abu, Akhter, Anwari, Caution, Kyle, Kotrange, Sheetal, Abdelaziz, Dalia H.A., Newland, Christie, Rosales-Reyes, Roberto, Kopp, Benjamin, McCoy, Karen, Montione, Richard, Schlesinger, Larry S., Gavrilin, Mikhail A., Wewers, Mark D., Valvano, Miguel A., Amer, Amal O.

“…Cystic fibrosis (CF) is the most common inherited lethal disease of Caucasians which results in multi organ dysfunction. However, 85% of the deaths are due to…”
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Gasdermin D restricts Burkholderia cenocepacia infection in vitro and in vivo by Estfanous, Shady, Krause, Kathrin, Anne, Midhun N. K., Eltobgy, Mostafa, Caution, Kyle, Abu Khweek, Arwa, Hamilton, Kaitlin, Badr, Asmaa, Daily, Kylene, Carafice, Cierra, Baetzhold, Daniel, Zhang, Xiaoli, Li, Tianliang, Wen, Haitao, Gavrilin, Mikhail A., Haffez, Hesham, Soror, Sameh, Amer, Amal O.

“…Burkholderia cenocepacia ( B. cenocepacia ) is an opportunistic bacterium; causing severe life threatening systemic infections in immunocompromised individuals…”
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Activation of the pyrin inflammasome by intracellular Burkholderia cenocepacia by Gavrilin, Mikhail A, Abdelaziz, Dalia H A, Mostafa, Mahmoud, Abdulrahman, Basant A, Grandhi, Jaykumar, Akhter, Anwari, Abu Khweek, Arwa, Aubert, Daniel F, Valvano, Miguel A, Wewers, Mark D, Amer, Amal O

“…Burkholderia cenocepacia is an opportunistic pathogen that causes chronic infection and induces progressive respiratory inflammation in cystic fibrosis…”
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Correction: IFN-γ Stimulates Autophagy-Mediated Clearance of Burkholderia cenocepacia in Human Cystic Fibrosis Macrophages by Assani, Kaivon, Tazi, Mia F, Amer, Amal O, Kopp, Benjamin T

“…[This corrects the article DOI: 10.1371/journal.pone.0096681.]…”
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