Search Results - "Amer, Amal"

The CATERPILLERS by Amer, Amal O

“…This Pillars of Immunology article is a commentary on “Cutting Edge: CATERPILLER: A large family of mammalian genes containing CARD, pyrin, nucleotide-binding,…”
Get full text

Factors Mediating Environmental Biofilm Formation by Legionella pneumophila by Abu Khweek, Arwa, Amer, Amal O

“…( ) is an opportunistic waterborne pathogen and the causative agent for Legionnaires' disease, which is transmitted to humans via inhalation of contaminated…”
Get full text

Pyroptotic and non‐pyroptotic effector functions of caspase‐11 by Abu Khweek, Arwa, Amer, Amal O.

“…Innate immune cells, epithelial cells, and many other cell types are capable of detecting infection or tissue injury, thus mounting regulated immune response…”
Get full text

Sequential ubiquitination of NLRP3 by RNF125 and Cbl-b limits inflammasome activation and endotoxemia by Tang, Juan, Tu, Sha, Lin, Guoxin, Guo, Hui, Yan, Chengkai, Liu, Qingjun, Huang, Ling, Tang, Na, Xiao, Yizhi, Pope, R Marshall, Rajaram, Murugesan V S, Amer, Amal O, Ahmer, Brian M, Gunn, John S, Wozniak, Daniel J, Tao, Lijian, Coppola, Vincenzo, Zhang, Liwen, Langdon, Wallace Y, Torrelles, Jordi B, Lipkowitz, Stanley, Zhang, Jian

“…Aberrant NLRP3 inflammasome activation contributes to the development of endotoxemia. The importance of negative regulation of NLRP3 inflammasomes remains…”
Get full text

IFN-γ stimulates autophagy-mediated clearance of Burkholderia cenocepacia in human cystic fibrosis macrophages by Assani, Kaivon, Tazi, Mia F, Amer, Amal O, Kopp, Benjamin T

“…Burkholderia cenocepacia is a virulent pathogen that causes significant morbidity and mortality in patients with cystic fibrosis (CF), survives intracellularly…”
Get full text

Caspase-11 Promotes the Fusion of Phagosomes Harboring Pathogenic Bacteria with Lysosomes by Modulating Actin Polymerization by Akhter, Anwari, Caution, Kyle, Abu Khweek, Arwa, Tazi, Mia, Abdulrahman, Basant A., Abdelaziz, Dalia H.A., Voss, Oliver H., Doseff, Andrea I., Hassan, Hoda, Azad, Abul K., Schlesinger, Larry S., Wewers, Mark D., Gavrilin, Mikhail A., Amer, Amal O.

“…Inflammasomes are multiprotein complexes that include members of the NLR (nucleotide-binding domain leucine-rich repeat containing) family and caspase-1. Once…”
Get full text

Inflammasome-dependent release of the alarmin HMGB1 in endotoxemia by Lamkanfi, Mohamed, Sarkar, Anasuya, Vande Walle, Lieselotte, Vitari, Alberto C, Amer, Amal O, Wewers, Mark D, Tracey, Kevin J, Kanneganti, Thirumala-Devi, Dixit, Vishva M

“…Endotoxin administration recapitulates many of the host responses to sepsis. Inhibitors of the cysteine protease caspase 1 have long been sought as a…”
Get full text

Physical activity prevents acute inflammation in a gout model by downregulation of TLR2 on circulating neutrophils as well as inhibition of serum CXCL1 and is associated with decreased pain and inflammation in gout patients by Jablonski, Kyle, Young, Nicholas A, Henry, Caitlin, Caution, Kyle, Kalyanasundaram, Anuradha, Okafor, Ifeoma, Harb, Peter, Schwarz, Emmy, Consiglio, Paul, Cirimotich, Chris M, Bratasz, Anna, Sarkar, Anasuya, Amer, Amal O, Jarjour, Wael N, Schlesinger, Naomi

“…Gout is the most prevalent inflammatory arthritis. To study the effects of regular physical activity and exercise intensity on inflammation and clinical…”
Get full text

Insights Into Mucosal Innate Immune Responses in House Dust Mite-Mediated Allergic Asthma by Abu Khweek, Arwa, Kim, Eunsoo, Joldrichsen, Marisa R, Amer, Amal O, Boyaka, Prosper N

“…The prevalence of asthma has been rising steadily for several decades, and continues to be a major public health and global economic burden due to both direct…”
Get full text

Cysteamine-mediated clearance of antibiotic-resistant pathogens in human cystic fibrosis macrophages by Shrestha, Chandra L, Assani, Kaivon D, Rinehardt, Hannah, Albastroiu, Florentina, Zhang, Shuzhong, Shell, Richard, Amer, Amal O, Schlesinger, Larry S, Kopp, Benjamin T

“…Members of the Burkholderia cepacia complex are virulent, multi-drug resistant pathogens that survive and replicate intracellularly in patients with cystic…”
Get full text

Structural stability of Burkholderia cenocepacia biofilms is reliant on eDNA structure and presence of a bacterial nucleic acid binding protein by Novotny, Laura A, Amer, Amal O, Brockson, M Elizabeth, Goodman, Steven D, Bakaletz, Lauren O

“…Cystic fibrosis (CF) is the most common lethal inherited genetic disorder affection Caucasians. Even with medical advances, CF is life-shortening with patients…”
Get full text

The Sphingosine-1-Phosphate Lyase (LegS2) Contributes to the Restriction of Legionella pneumophila in Murine Macrophages by Abu Khweek, Arwa, Kanneganti, Apurva, Guttridge D, Denis C, Amer, Amal O

“…L. pneumophila is the causative agent of Legionnaires' disease, a human illness characterized by severe pneumonia. In contrast to those derived from humans,…”
Get full text

Aging is associated with hypermethylation of autophagy genes in macrophages by Khalil, Hany, Tazi, Mia, Caution, Kyle, Ahmed, Amr, Kanneganti, Apurva, Assani, Kaivon, Kopp, Benjamin, Marsh, Clay, Dakhlallah, Duaa, Amer, Amal O.

“…Autophagy is a biological process characterized by self-digestion and involves induction of autophagosome formation, leading to degradation of autophagic…”
Get full text

Checks and Balances between Autophagy and Inflammasomes during Infection by Seveau, Stephanie, Turner, Joanne, Gavrilin, Mikhail A., Torrelles, Jordi B., Hall-Stoodley, Luanne, Yount, Jacob S., Amer, Amal O.

“…Autophagy and inflammasome complex assembly are physiological processes that control homeostasis, inflammation, and immunity. Autophagy is a ubiquitous pathway…”
Get full text

Cystic fibrosis macrophage function and clinical outcomes after elexacaftor/tezacaftor/ivacaftor by Zhang, Shuzhong, Shrestha, Chandra L, Robledo-Avila, Frank, Jaganathan, Devi, Wisniewski, Benjamin L, Brown, Nevian, Pham, Hanh, Carey, Katherine, Amer, Amal O, Hall-Stoodley, Luanne, McCoy, Karen S, Bai, Shasha, Partida-Sanchez, Santiago, Kopp, Benjamin T

“…Abnormal macrophage function caused by dysfunctional cystic fibrosis transmembrane conductance regulator (CFTR) is a critical contributor to chronic airway…”
Get full text

Correction: IFN-γ Stimulates Autophagy-Mediated Clearance of Burkholderia cenocepacia in Human Cystic Fibrosis Macrophages by Assani, Kaivon, Tazi, Mia F, Amer, Amal O, Kopp, Benjamin T

“…[This corrects the article DOI: 10.1371/journal.pone.0096681.]…”
Get full text

The septin cytoskeleton is required for plasma membrane repair by Prislusky, M Isabella, Lam, Jonathan G T, Contreras, Viviana Ruiz, Ng, Marilynn, Chamberlain, Madeline, Pathak-Sharma, Sarika, Fields, Madalyn, Zhang, Xiaoli, Amer, Amal O, Seveau, Stephanie

“…Plasma membrane repair is a fundamental homeostatic process of eukaryotic cells. Here, we report a new function for the conserved cytoskeletal proteins known…”
Get full text

CASP4/caspase-11 promotes autophagosome formation in response to bacterial infection by Krause, Kathrin, Caution, Kyle, Badr, Asmaa, Hamilton, Kaitlin, Saleh, Abdulmuti, Patel, Khushbu, Seveau, Stephanie, Hall-Stoodley, Luanne, Hegazi, Rana, Zhang, Xiaoli, Gavrilin, Mikhail A., Amer, Amal O.

“…CASP4/caspase-11-dependent inflammasome activation is important for the clearance of various Gram-negative bacteria entering the host cytosol. Additionally,…”
Get full text

Caspase-11 Mediates Neutrophil Chemotaxis and Extracellular Trap Formation During Acute Gouty Arthritis Through Alteration of Cofilin Phosphorylation by Caution, Kyle, Young, Nicholas, Robledo-Avila, Frank, Krause, Kathrin, Abu Khweek, Arwa, Hamilton, Kaitlin, Badr, Asmaa, Vaidya, Anup, Daily, Kylene, Gosu, Hawin, Anne, Midhun N K, Eltobgy, Mostafa, Dakhlallah, Duaa, Argwal, Sudha, Estfanous, Shady, Zhang, Xiaoli, Partida-Sanchez, Santiago, Gavrilin, Mikhail A, Jarjour, Wael N, Amer, Amal O

“…Gout is characterized by attacks of arthritis with hyperuricemia and monosodium urate (MSU) crystal-induced inflammation within joints. Innate immune responses…”
Get full text

Caspase-7 activation by the Nlrc4/Ipaf inflammasome restricts Legionella pneumophila infection by Akhter, Anwari, Gavrilin, Mikhail A, Frantz, Laura, Washington, Songcerae, Ditty, Cameron, Limoli, Dominique, Day, Colby, Sarkar, Anasuya, Newland, Christie, Butchar, Jonathan, Marsh, Clay B, Wewers, Mark D, Tridandapani, Susheela, Kanneganti, Thirumala-Devi, Amer, Amal O

“…Legionella pneumophila (L. pneumophila), the causative agent of a severe form of pneumonia called Legionnaires' disease, replicates in human monocytes and…”
Get full text