Search Results - "Ameeruddin, Nusrath Unissa"

Overview on mechanisms of isoniazid action and resistance in Mycobacterium tuberculosis by Unissa, Ameeruddin Nusrath, Subbian, Selvakumar, Hanna, Luke Elizabeth, Selvakumar, Nagamiah

“…Isoniazid (INH) is one of the most active compounds used to treat tuberculosis (TB) worldwide. In addition, INH has been used as a prophylactic drug for…”
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Molecular mechanisms of action, resistance, detection to the first-line anti tuberculosis drugs: Rifampicin and pyrazinamide in the post whole genome sequencing era by Nusrath Unissa, Ameeruddin, Hanna, Luke Elizabeth

“…Recent studies in addition to studies based on whole genome sequencing (WGS) of clinical isolates of Mycobacterium tuberculosis (MTB) from diverse geographical…”
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A Note on Derivatives of Isoniazid, Rifampicin, and Pyrazinamide Showing Activity Against Resistant Mycobacterium tuberculosis by Nusrath Unissa, Ameeruddin, Hanna, Luke Elizabeth, Swaminathan, Soumya

“…Drug‐resistant tuberculosis (DR‐TB) is a serious problem that impedes the success of the TB control program. Of note, multidrug‐resistant (MDR)‐TB and…”
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The Role of N-Acetyl Transferases on Isoniazid Resistance from Mycobacterium tuberculosis and Human: An In Silico Approach by Unissa, Ameeruddin Nusrath, Sukumar, Swathi, Hanna, Luke Elizabeth

“…Background: N-acetyl transferase (NAT) inactivates the pro-drug isoniazid (INH) to N-acetyl INH through a process of acetylation, and confers low-level…”
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Insights into RpoB clinical mutants in mediating rifampicin resistance in Mycobacterium tuberculosis by Nusrath Unissa, Ameeruddin, Hassan, Sameer, Indira Kumari, Venkatesan, Revathy, Ravi, Hanna, Luke Elizabeth

“…[Display omitted] •Rifampicin (RIF) an essential first-line anti-tuberculosis (TB) drug, resistance to RIF is a potential threat to TB control program and…”
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The Role of N -Acetyl Transferases on Isoniazid Resistance from Mycobacterium tuberculosis and Human: An In Silico Approach by Unissa, Ameeruddin Nusrath, Sukumar, Swathi, Hanna, Luke Elizabeth

“…-acetyl transferase (NAT) inactivates the pro-drug isoniazid (INH) to -acetyl INH through a process of acetylation, and confers low-level resistance to INH in…”
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Molecular mechanism of action, resistance, detection to the first-line anti tuberculosis drugs: Rifampicin and pyrazinamide by Nusrath Unissa, Ameeruddin, Hanna, Luke Elizabeth

“…Abstract Recent studies in addition to studies based on whole genome sequencing (WGS) of clinical isolates of Mycobacterium tuberculosis (MTB) from diverse…”
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Impact of isoniazid resistance on virulence of global and south Indian clinical isolates of Mycobacterium tuberculosis by Ameeruddin, Nusrath Unissa, Luke Elizabeth, Hanna

“…Abstract Isoniazid (INH) is the only anti-tuberculous drug for which a relationship has been noticed between acquisition of resistance and lack of virulence…”
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Significance of catalase-peroxidase (KatG) mutations in mediating isoniazid resistance in clinical strains of Mycobacterium tuberculosis by Unissa, Ameeruddin Nusrath, Doss C, George Priya, Kumar, Thirumal, Sukumar, Swathi, Lakshmi, Appisetty Ramya, Hanna, Luke Elizabeth

“…•Clinical importance of five KatG mutants (MTs) leading to isoniazid (INH) resistance was investigated in silico.•Binding affinity based on docking was found…”
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Analysis of interactions of clinical mutants of catalase-peroxidase (KatG) responsible for isoniazid resistance in Mycobacterium tuberculosis with derivatives of isoniazid by Unissa, Ameeruddin Nusrath, Doss C., George Priya, Kumar, Thirumal, Swathi, Sukumar, Lakshmi, Appisetty Ramya, Hanna, Luke Elizabeth

“…•Mutations at codon 315 in katG are the major cause of isoniazid (INH) resistance in Mycobacterium tuberculosis (MTB).•Study of the binding interaction of all…”
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Binding of activated isoniazid with acetyl-CoA carboxylase from Mycobacterium tuberculosis by Unissa, Ameeruddin Nusrath, Sudha, Subramanian, Selvakumar, Nagamiah, Hassan, Sameer

“…AccD6 (acetyl coenzyme A (CoA) carboxylase), plays an important role in mycolic acid synthesis of Mycobacterium tuberculosis (Mtb). Induced gene expression by…”
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