Search Results - "Ameen, Nadia A"

Physiological relevance of cell-specific distribution patterns of CFTR, NKCC1, NBCe1, and NHE3 along the crypt-villus axis in the intestine by Jakab, Robert L, Collaco, Anne M, Ameen, Nadia A

“…We examined the cell-specific subcellular expression patterns for sodium- and potassium-coupled chloride (NaK2Cl) cotransporter 1 (NKCC1), Na(+) bicarbonate…”
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Zinc ameliorates intestinal barrier dysfunctions in shigellosis by reinstating claudin-2 and -4 on the membranes by Sarkar, Paramita, Saha, Tultul, Sheikh, Irshad Ali, Chakraborty, Subhra, Aoun, Joydeep, Chakrabarti, Manoj Kumar, Rajendran, Vazhaikkurichi M, Ameen, Nadia A, Dutta, Shanta, Hoque, Kazi Mirajul

“…Whether zinc (Zn ) regulates barrier functions by modulating tight-junction (TJ) proteins when pathogens such as Shigella alter epithelial permeability is…”
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CFTR High Expresser Cells in cystic fibrosis and intestinal diseases by Carlos dos Reis, Diego, Dastoor, Parinaz, Santos, Anderson Kenedy, Sumigray, Kaelyn, Ameen, Nadia A.

“…Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), the Cl−/HCO3− channel implicated in Cystic Fibrosis, is critical to the pathophysiology of many…”
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Linaclotide activates guanylate cyclase‐C/cGMP/protein kinase‐II‐dependent trafficking of CFTR in the intestine by Ahsan, Md. Kaimul, Tchernychev, Boris, Kessler, Marco M., Solinga, Robert M., Arthur, David, Linde, Cristina I., Silos‐Santiago, Inmaculada, Hannig, Gerhard, Ameen, Nadia A.

“…The transmembrane receptor guanylyl cyclase‐C (GC‐C), expressed on enterocytes along the intestine, is the molecular target of the GC‐C agonist peptide…”
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Myosin Ia is Required for CFTR Brush Border Membrane Trafficking and Ion Transport in the Mouse Small Intestine by Kravtsov, Dmitri V., Caputo, Christina, Collaco, Anne, Hoekstra, Nadia, Egan, Marie E., Mooseker, Mark S., Ameen, Nadia A.

“…In enterocytes of the small intestine, endocytic trafficking of CFTR channels from the brush border membrane (BBM) to the subapical endosomes requires the…”
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Molecular motors and apical CFTR traffic in epithelia by Kravtsov, Dmitri V, Ameen, Nadia A

“…Intracellular protein traffic plays an important role in the regulation of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) chloride channels…”
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Localization and function of humanized F508del-CFTR in mouse intestine following activation of serum glucocorticoid kinase 1 and Trikafta by Dastoor, Parinaz, Muiler, Caroline, Garrison, Alannah, Egan, Marie, Carlos dos Reis, Diego, Santos, Anderson, Ameen, Nadia A.

“…The CFTR modulator Trikafta has markedly improved lung disease for Cystic Fibrosis (CF) patients carrying the common delta F508 (F508del-CFTR) CFTR mutation…”
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Generation and Manipulation of Rat Intestinal Organoids by Zagoren, Eleanor, Santos, Anderson K, Ameen, Nadia A, Sumigray, Kaelyn

“…When using organoids to assess physiology and cell fate decisions, it is important to use a model that closely recapitulates in vivo contexts. Accordingly,…”
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Serum and Glucocorticoid‐Inducible Kinase 1 (SGK1): An Important Contributor to Diarrhea and Malabsorption in Microvillus Inclusion Disease (MVID) by Ahsan, Md Kaimul, Reis, Diego Carlos, Barbieri, Andrea, Sumigray, Kaelyn, Nottoli, Timothy, Salas, Pedro J., Ameen, Nadia A.

“…Microvillus Inclusion Disease (MVID) is a lethal congenital diarrheal disease resulting from loss of function mutations in the actin motor myosin VB (MYO5B)…”
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Glucocorticoids and myosin5b loss of function induce heightened PKA signaling in addition to membrane traffic defects by Forteza, Radia, Ahsan, M Kaimul, Cartón-García, Fernando, Arango, Diego, Ameen, Nadia A, Salas, Pedro J

“…Loss-of-function mutations in the nonconventional myosin Vb (Myo5b) result in microvillus inclusion disease (MVID) and massive secretory diarrhea that often…”
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Heterogeneity in mouse spasmolytic polypeptide-expressing metaplasia lineages identifies markers of metaplastic progression by Weis, Victoria G, Sousa, Josane F, LaFleur, Bonnie J, Nam, Ki Taek, Weis, Jared A, Finke, Paul E, Ameen, Nadia A, Fox, James G, Goldenring, James R

“…Spasmolytic polypeptide-expressing metaplasia (SPEM) develops as a preneoplastic lesion in the stomachs of mice and humans after parietal cell loss. To…”
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AP2 α modulates cystic fibrosis transmembrane conductance regulator function in the human intestine by Kumari, Vandana, Desai, Shruti, Ameen, Nadia A

“…Abstract Background AP2 is a clathrin-based endocytic adaptor complex comprising α, β2, μ2 and σ2 subunits. μ2 regulates CFTR endocytosis. The α subunit…”
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Glucocorticoids and serum- and glucocorticoid-inducible kinase 1 are potent regulators of CFTR in the native intestine: implications for stress-induced diarrhea by Ahsan, Md Kaimul, Figueroa-Hall, Leandra, Baratta, Vanessa, Garcia-Milian, Rolando, Lam, TuKiet T, Hoque, Kazi, Salas, Pedro J, Ameen, Nadia A

“…Nongenomic glucocorticoid (GC) and serum- and glucocorticoid-inducible kinase 1 (SGK1) signaling regulate ion transport, but CFTR has not been investigated in…”
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Characterization of CFTR High Expresser cells in the intestine by Jakab, Robert L, Collaco, Anne M, Ameen, Nadia A

“…The CFTR High Expresser (CHE) cells express eightfold higher levels of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channel compared…”
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Myosin 5b loss of function leads to defects in polarized signaling: implication for microvillus inclusion disease pathogenesis and treatment by Kravtsov, Dmitri, Mashukova, Anastasia, Forteza, Radia, Rodriguez, Maria M, Ameen, Nadia A, Salas, Pedro J

“…Microvillus inclusion disease (MVID) is an autosomal recessive condition resulting in intractable secretory diarrhea in newborns due to loss-of-function…”
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Lubiprostone Targets Prostanoid Signaling and Promotes Ion Transporter Trafficking, Mucus Exocytosis, and Contractility by Jakab, Robert L., Collaco, Anne M., Ameen, Nadia A.

“…Background and Aim Lubiprostone is a chloride channel activator in clinical use for the treatment of chronic constipation, but the mechanisms of action of the…”
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Identification of intestinal ion transport defects in microvillus inclusion disease by Kravtsov, Dmitri V, Ahsan, Md Kaimul, Kumari, Vandana, van Ijzendoorn, Sven C D, Reyes-Mugica, Miguel, Kumar, Anoop, Gujral, Tarunmeet, Dudeja, Pradeep K, Ameen, Nadia A

“…Loss of function mutations in the actin motor myosin Vb (Myo5b) lead to microvillus inclusion disease (MVID) and death in newborns and children. MVID results…”
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Microvillus Inclusion Disease: A Genetic Defect Affecting Apical Membrane Protein Traffic in Intestinal Epithelium by Ameen, Nadia A., Salas, Pedro J.I.

“…The striking similarities between microvillus inclusions (MIs) in enterocytes in microvillus inclusion disease (MID) and vacuolar apical compartment in tissue…”
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Cell-specific effects of luminal acid, bicarbonate, cAMP, and carbachol on transporter trafficking in the intestine by Jakab, Robert L, Collaco, Anne M, Ameen, Nadia A

“…Changes in intestinal luminal pH affect mucosal ion transport. The aim of this study was to compare how luminal pH and specific second messengers modulate the…”
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Functional vacuolar ATPase (V-ATPase) proton pumps traffic to the enterocyte brush border membrane and require CFTR by Collaco, Anne M, Geibel, Peter, Lee, Beth S, Geibel, John P, Ameen, Nadia A

“…Vacuolar ATPases (V-ATPases) are highly conserved proton pumps that regulate organelle pH. Epithelial luminal pH is also regulated by cAMP-dependent traffic of…”
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