Search Results - "Ambrus, Csilla"

The Inhibitor Preincubation Effect Is Universal to SLC Transporter Assays and Is Only Partially Eliminated in the Presence of Extracellular Protein by Tátrai, Péter, Temesszentandrási-Ambrus, Csilla, Varga, Tamás, Gáborik, Zsuzsanna

“…Variation in the methodology of in vitro transporter inhibition assays causes wide divergence in reported IC /K data. Notably, although potentiation of…”
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Interactions of anti-COVID-19 drug candidates with hepatic transporters may cause liver toxicity and affect pharmacokinetics by Ambrus, Csilla, Bakos, Éva, Sarkadi, Balázs, Özvegy-Laczka, Csilla, Telbisz, Ágnes

“…Transporters in the human liver play a major role in the clearance of endo- and xenobiotics. Apical (canalicular) transporters extrude compounds to the bile,…”
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A Unique In Vitro Assay to Investigate ABCB4 Transport Function by Temesszentandrási-Ambrus, Csilla, Nagy, Gábor, Bui, Annamária, Gáborik, Zsuzsanna

“…ABCB4 is almost exclusively expressed in the liver, where it plays an essential role in bile formation by transporting phospholipids into the bile. ABCB4…”
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Interactions of the Anti-SARS-CoV-2 Agents Molnupiravir and Nirmatrelvir/Paxlovid with Human Drug Transporters by Bakos, Éva, Temesszentandrási-Ambrus, Csilla, Özvegy-Laczka, Csilla, Gáborik, Zsuzsanna, Sarkadi, Balázs, Telbisz, Ágnes

“…Orally administered small molecules may have important therapeutic potential in treating COVID-19 disease. The recently developed antiviral agents,…”
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Baicalin is a substrate of OATP2B1 and OATP1B3 by Kalapos‐Kovács, Bernadett, Juhász, Viktória, Temesszentandrási‐Ambrus, Csilla, Magda, Balázs, Szabó, Pál T., Antal, István, Klebovich, Imre, Krajcsi, Péter

“…The use and significance of baicalin, the main bioactive component found in Radix Scutellaria, have been on the rise due to its interesting pharmacological…”
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Translatability of in vitro Inhibition Potency to in vivo P-Glycoprotein Mediated Drug Interaction Risk by Lazzaro, Sarah, West, Mark A, Eatemadpour, Soraya, Feng, Bo, Varma, Manthena V S, Rodrigues, A David, Temesszentandrási-Ambrus, Csilla, Kovács-Hajdu, Péter, Nerada, Zsuzsanna, Gáborik, Zsuzsanna, Costales, Chester

“…P-glycoprotein (P-gp) may limit oral drug absorption of substrate drugs due to intestinal efflux. Therefore, regulatory agencies require investigation of new…”
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Identification of reversible OATP1B1 and time-dependent CYP3A4 inhibition as the major risk factors for drug-induced cholestasis (DIC) by Kastrinou-Lampou, Vlasia, Rodríguez-Pérez, Raquel, Poller, Birk, Huth, Felix, Gáborik, Zsuzsanna, Mártonné-Tóth, Beáta, Temesszentandrási-Ambrus, Csilla, Schadt, Heiko S., Kullak-Ublick, Gerd A., Arand, Michael, Camenisch, Gian

“…Hepatic bile acid regulation is a multifaceted process modulated by several hepatic transporters and enzymes. Drug-induced cholestasis (DIC), a main type of…”
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Applicability of MDR1 Overexpressing Abcb1KO-MDCKII Cell Lines for Investigating In Vitro Species Differences and Brain Penetration Prediction by Sóskuti, Emőke, Szilvásy, Nóra, Temesszentandrási-Ambrus, Csilla, Urbán, Zoltán, Csíkvári, Olivér, Szabó, Zoltán, Kecskeméti, Gábor, Pusztai, Éva, Gáborik, Zsuzsanna

“…Implementing the 3R initiative to reduce animal experiments in brain penetration prediction for CNS-targeting drugs requires more predictive in vitro and in…”
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Interactions of Potential Anti-COVID-19 Compounds with Multispecific ABC and OATP Drug Transporters by Telbisz, Ágnes, Ambrus, Csilla, Mózner, Orsolya, Szabó, Edit, Várady, György, Bakos, Éva, Sarkadi, Balázs, Özvegy-Laczka, Csilla

“…During the COVID-19 pandemic, several repurposed drugs have been proposed to alleviate the major health effects of the disease. These drugs are often applied…”
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Structure and function of BCRP, a broad specificity transporter of xenobiotics and endobiotics by Jani, Márton, Ambrus, Csilla, Magnan, Rémi, Jakab, Katalin Tauberné, Beéry, Erzsébet, Zolnerciks, Joseph K., Krajcsi, Péter

“…The discovery and characterization of breast cancer resistance protein (BCRP) as an efflux transporter conferring multidrug resistance has set off a remarkable…”
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Characterization of new, efficient Mycobacterium tuberculosis topoisomerase-I inhibitors and their interaction with human ABC multidrug transporters by Temesszentandrási-Ambrus, Csilla, Tóth, Szilárd, Verma, Rinkee, Bánhegyi, Péter, Szabadkai, István, Baska, Ferenc, Szántai-Kis, Csaba, Hartkoorn, Ruben C, Lingerfelt, Mary A, Sarkadi, Balázs, Szakács, Gergely, Őrfi, László, Nagaraja, Valakunja, Ekins, Sean, Telbisz, Ágnes

“…Drug resistant tuberculosis (TB) is a major worldwide health problem. In addition to the bacterial mechanisms, human drug transporters limiting the cellular…”
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Intracellular Metabolomics Identifies Efflux Transporter Inhibitors in a Routine Caco-2 Cell Permeability Assay-Biological Implications by Naseem, Afia, Pal, Akos, Gowan, Sharon, Asad, Yasmin, Donovan, Adam, Temesszentandrási-Ambrus, Csilla, Kis, Emese, Gaborik, Zsuzsanna, Bhalay, Gurdip, Raynaud, Florence

“…Caco-2 screens are routinely used in laboratories to measure the permeability of compounds and can identify substrates of efflux transporters. In this study,…”
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PPARγ modulated inflammatory response of human dendritic cell subsets to engulfed apoptotic neutrophils by Majai, Gyöngyike, Gogolák, Péter, Ambrus, Csilla, Vereb, György, Hodrea, Judit, Fésüs, László, Rajnavölgyi, Eva

“…PPARγ expression and activation in CD1a– monocyte derived dendritic cells modulates the engulfment of and the cytokine and T cell response to apoptotic…”
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Role of drug transporters in the central nervous system by Erdő, Franciska, Temesszentandrási-Ambrus, Csilla, Beéry, Erzsébet

“…Although the presence of blood-brain barrier in the mammalian organisms was discovered in the early 1900s, its precise structure and the drug transporter…”
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Interactions between Maraviroc and the ABCB1, ABCG2, and ABCC2 Transporters: An Important Role in Transplacental Pharmacokinetics by Tupova, Lenka, Ceckova, Martina, Ambrus, Csilla, Sorf, Ales, Ptackova, Zuzana, Gaborik, Zsuzsanna, Staud, Frantisek

“…Maraviroc is a chemokine receptor 5 (CCR5) inhibitor used in the treatment of human immunodeficiency virus (HIV) that also shows therapeutic potential for…”
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Investigating cross-species differences of MDR1-mediated drug transport by Temesszentandrasi-Ambrus, Csilla, Heredi-Szabo, Krisztina, Soskuti, Emoke, Szilvasy, Nora, Kis, Emese, Gaborik, Zsuzsanna

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Modulation of Multispecific Transporters by Uncaria tomentosa Extract and Its Major Phytoconstituents by Szilvásy, Nóra, Lajer, Panna, Horváth, Attila, Veres, Katalin, Hohmann, Judit, Schelz, Zsuzsanna, Minorics, Renáta, Zupkó, István, Gáborik, Zsuzsanna, Kis, Emese, Temesszentandrási-Ambrus, Csilla

“…Background/Objectives: One of the major risks associated with the concomitant use of herbal products and therapeutic drugs is herb–drug interactions (HDIs)…”
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PPARg modulated inflammatory response of human dendritic cell subsets to engulfed apoptotic neutrophils by Majai, Gyoengyike, Gogolak, Peter, Ambrus, Csilla, Vereb, Gyoergy, Hodrea, Judit, Fesues, Laszlo, Rajnavoelgyi, Eva

“…The means of how phagocytes handle apoptotic cells has a great impact on the outcome of immune responses. Here, we show that phagocytosis of allogeneic,…”
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