Search Results - "Ambrosio, Antonio F"

Contribution of Microglia-Mediated Neuroinflammation to Retinal Degenerative Diseases by Ambrósio, António F., Santos, Paulo F., Boia, Raquel, Madeira, Maria H., Santiago, Ana R.

“…Retinal degenerative diseases are major causes of vision loss and blindness worldwide and are characterized by chronic and progressive neuronal loss. One…”
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Microglia sequelae: brain signature of innate immunity in schizophrenia by Rodrigues-Neves, A. Catarina, Ambrósio, António. F., Gomes, Catarina A.

“…Schizophrenia is a psychiatric disorder with significant impact on individuals and society. The current pharmacologic treatment, which principally alleviates…”
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Tracing the influence of prenatal risk factors on the offspring retina: Focus on development and putative long‐term consequences by Baptista, Filipa I., Ambrósio, António F.

“…Background Pregnancy represents a window of vulnerability to fetal development. Disruptions in the prenatal environment during this crucial period can increase…”
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Having a Coffee Break: The Impact of Caffeine Consumption on Microglia-Mediated Inflammation in Neurodegenerative Diseases by Santiago, Ana R., Ambrósio, António F., Boia, Raquel, Madeira, Maria H.

“…Caffeine is the major component of coffee and the most consumed psychostimulant in the world and at nontoxic doses acts as a nonselective adenosine receptor…”
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Disruption of a neural microcircuit in the rod pathway of the mammalian retina by diabetes mellitus by Castilho, Áurea, Ambrósio, António F, Hartveit, Espen, Veruki, Margaret L

“…Diabetes leads to dysfunction of the neural retina before and independent of classical microvascular diabetic retinopathy, but previous studies have failed to…”
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Calcium Dobesilate Inhibits the Alterations in Tight Junction Proteins and Leukocyte Adhesion to Retinal Endothelial Cells Induced by Diabetes by LEAL, Ermelindo C, MARTINS, Joao, VOABIL, Paula, LIBERAL, Joana, CHIAVAROLI, Carlo, BAUER, Jacques, CUNHA-VAZ, José, AMBROSIO, António F

“…Calcium dobesilate (CaD) has been used in the treatment of diabetic retinopathy in the last decades, but its mechanisms of action are not elucidated. CaD is…”
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Maternal diabetes affects rat offspring retinal structure and function: Sex-specific vulnerabilities at infancy by Realinho, Ana M., Boia, Raquel, Paiva, Beatriz, Correia, Raquel G., Gaspar, Rita, Ambrósio, António F., Baptista, Filipa I.

“…Maternal diabetes negatively impacts the offspring's brain, but little is known about its effects on the retina, which is also part of the central nervous…”
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Methamphetamine-induced nitric oxide promotes vesicular transport in blood–brain barrier endothelial cells by Martins, Tânia, Burgoyne, Thomas, Kenny, Bridget-Ann, Hudson, Natalie, Futter, Clare E., Ambrósio, António F., Silva, Ana P., Greenwood, John, Turowski, Patric

“…Methamphetamine's (METH) neurotoxicity is thought to be in part due to its ability to induce blood–brain barrier (BBB) dysfunction. Here, we investigated the…”
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Role of Microglia Adenosine A_(2A) Receptors in Retinal and Brain Neurodegenerative Diseases by Santiago, Ana R, Baptista, Filipa I, Santos, Paulo F, Cristovao, Goncalo, Ambrosio, Antonio F, Cunha, Rodrigo A, Gomes, Catarina A

“…Neuroinflammation mediated by microglial cells in the brain has been commonly associated with neurodegenerative diseases. Whether this microglia-mediated…”
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The dipeptidyl peptidase-4 (DPP-4) inhibitor sitagliptin ameliorates retinal endothelial cell dysfunction triggered by inflammation by Gonçalves, Andreia, Almeida, Luísa, Silva, Ana Paula, Fontes-Ribeiro, Carlos, Ambrósio, António F., Cristóvão, Armando, Fernandes, Rosa

“…•TNF-α neither affects basal DPP-4 activity nor influences sitagliptin ability to inhibit DPP-4 in retinal endothelial cells.•Retinal EC permeability induced…”
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Diabetic hyperglycemia reduces Ca2+ permeability of extrasynaptic AMPA receptors in AII amacrine cells by Castilho, Áurea, Madsen, Eirik, Ambrósio, António F, Veruki, Margaret L, Hartveit, Espen

“…There is increasing evidence that diabetic retinopathy is a primary neuropathological disorder that precedes the microvascular pathology associated with later…”
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Sexual dimorphism of the adult human retina assessed by optical coherence tomography by Nunes, Ana, Serranho, Pedro, Quental, Hugo, Ambrósio, António F., Castelo-Branco, Miguel, Bernardes, Rui

“…Sexual dimorphism in the human visual system is a well-established phenomenon, and recent research has unveiled possible connections between gonadal hormones…”
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Diabetes induces changes in KIF1A, KIF5B and dynein distribution in the rat retina: Implications for axonal transport by Baptista, Filipa I., Pinto, Maria J., Elvas, Filipe, Martins, Tiago, Almeida, Ramiro D., Ambrósio, António F.

“…Diabetic retinopathy is a leading cause of vision loss and blindness. Disruption of axonal transport is associated with many neurodegenerative diseases and…”
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Neuropeptide Y system mRNA expression changes in the hippocampus of a type I diabetes rat model by Campos, Elisa J., Martins, João, Brudzewsky, Dan, Woldbye, David P.D., Ambrósio, António F.

“…Neuropeptide Y (NPY) plays a crucial role in many neurobiological functions, such as cognition and memory. Cognitive and memory impairment have been described…”
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Diabetes causes transient changes in the composition and phosphorylation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors and interaction with auxiliary proteins in the rat retina by Castilho, Aurea F, Liberal, Joana T, Baptista, Filipa I, Gaspar, Joana M, Carvalho, Ana Luísa, Ambrósio, António F

“…The impairment of glutamatergic neurotransmission has been associated with diabetic complications in the central nervous system, such as diabetic retinopathy…”
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Elevated Glucose Changes the Expression of Ionotropic Glutamate Receptor Subunits and Impairs Calcium Homeostasis in Retinal Neural Cells by Santiago, Ana R, Rosa, Susana C, Santos, Paulo F, Cristovao, Armando J, Barber, Alistair J, Ambrosio, Antonio F

“…Altered glutamatergic neurotransmission and calcium homeostasis may contribute to retinal neural cell dysfunction and apoptosis in diabetic retinopathy (DR)…”
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Modification of adenosine A1 and A2A receptor density in the hippocampus of streptozotocin-induced diabetic rats by DUARTE, Joao M. N, OLIVEIRA, Catarina R, AMBROSIO, Antonio F, CUNHA, Rodrigo A

“…Adenosine A(1) and A(2A) receptors are neuromodulatory systems that can control mnemonic behavior, which is modified by diabetes. Since the density of these…”
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Electrochemical Immunosensor for TNFα-Mediated Inflammatory Disease Screening by Cruz, Andrea, Queirós, Raquel, Abreu, Catarina M, Barata, Catarina, Fernandes, Rosa, Silva, Rufino, Ambrósio, Antonio F, Soares-dos-Reis, Ricardo, Guimarães, Joana, Sá, Maria José, Relvas, João B, Freitas, Paulo P, Mendes Pinto, Inês

“…Inflammation associated with cancer, neurodegenerative, ocular, and autoimmune diseases has a considerable impact on public health. Tumor necrosis factor alpha…”
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Elevated Glucose and Interleukin-1[beta] Differentially Affect Retinal Microglial Cell Proliferation by Baptista, Filipa I, Aveleira, Celia A, Castilho, Aurea F, Ambrosio, Antonio F

“…Diabetic retinopathy is considered a neurovascular disorder, hyperglycemia being considered the main risk factor for this pathology. Diabetic retinopathy also…”
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TNF-α Signals Through PKCζ/NF-κB to Alter the Tight Junction Complex and Increase Retinal Endothelial Cell Permeability by AVELEIRA, Célia A, LIN, Cheng-Mao, ABCOUWER, Steven F, AMBROSIO, António F, ANTONETTI, David A

“…Tumor necrosis factor-α (TNF-α) and interleukin-1 beta (IL-1β) are elevated in the vitreous of diabetic patients and in retinas of diabetic rats associated…”
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