Search Results - "Ambrose, Paul G."

Pharmacodynamics of Tebipenem: New Options for Oral Treatment of Multidrug-Resistant Gram-Negative Infections by McEntee, Laura, Johnson, Adam, Farrington, Nicola, Unsworth, Jennifer, Dane, Aaron, Jain, Akash, Cotroneo, Nicole, Critchley, Ian, Melnick, David, Parr, Thomas, Ambrose, Paul G, Das, Shampa, Hope, William

“…Tebipenem pivoxil HBr (TBPM-PI-HBr) is a novel orally bioavailable carbapenem. The active moiety is tebipenem. Tebipenem pivoxil is licensed for use in Japan…”
Get full text

Extended-Spectrum β-Lactamases and Clinical Outcomes: Current Data by Ramphal, Reuben, >, Paul G. Ambrose

“…Nosocomial infections caused by extended-spectrum β-lactamase (ESBL)—producing gram-negative bacteria complicate therapy and limit treatment options. However,…”
Get full text

Pharmacokinetics-Pharmacodynamics of Antimicrobial Therapy: It's Not Just for Mice Anymore by Ambrose, Paul G., Bhavnani, Sujata M., Rubino, Christopher M., Louie, Arnold, Gumbo, Tawanda, Forrest, Alan, Drusano, George L.

“…Since the advent of the modern era of antimicrobial chemotherapy in the 1930s, animal infection models have allowed for the in vivo evaluation of antimicrobial…”
Get full text

Daptomycin Exposure and the Probability of Elevations in the Creatine Phosphokinase Level: Data from a Randomized Trial of Patients with Bacteremia and Endocarditis by Bhavnani, Sujata M., Rubino, Christopher M., Ambrose, Paul G., Drusano, George L.

“…Background. The objective of this analysis was to evaluate the relationship between daptomycin exposure and the probability of an elevation in the creatine…”
Get full text

Polymyxin Susceptibility Testing and Interpretive Breakpoints: Recommendations from the United States Committee on Antimicrobial Susceptibility Testing (USCAST) by Pogue, Jason M, Jones, Ronald N, Bradley, John S, Andes, David R, Bhavnani, Sujata M, Drusano, George L, Dudley, Michael N, Flamm, Robert K, Rodvold, Keith A, Ambrose, Paul G

“…The polymyxins are important agents for carbapenem-resistant Gram-negative bacilli. The United States Committee on Antimicrobial Susceptibility Testing…”
Get full text

Conserving antibiotics for the future: New ways to use old and new drugs from a pharmacokinetic and pharmacodynamic perspective by Mouton, Johan W, Ambrose, Paul G, Canton, Rafael, Drusano, George L, Harbarth, Stephan, MacGowan, Alasdair, Theuretzbacher, Ursula, Turnidge, John

“…Abstract There is a growing need to optimize the use of old and new antibiotics to treat serious as well as less serious infections. The topic of how to use…”
Get full text

Antimicrobial Safety: Focus on Fluoroquinolones by Owens, Robert C., Ambrose, Paul G.

“…Background/purpose. Infrequent toxicities associated with certain drugs and drug classes have recently gained much attention from different health-care…”
Get full text

Evaluation of Daptomycin Exposure and Efficacy and Safety Endpoints To Support Risk-versus-Benefit Considerations by Bhavnani, Sujata M, Ambrose, Paul G, Hammel, Jeffrey P, Rubino, Christopher M, Drusano, George L

“…The choice of an antimicrobial agent must balance optimization of efficacy endpoints with the minimization of safety events. The risk versus benefit of…”
Get full text

Pharmacokinetic-Pharmacodynamic Considerations in the Design of Hospital-Acquired or Ventilator-Associated Bacterial Pneumonia Studies: Look before You Leap by Ambrose, Paul G., Bhavnani, Sujata M., Grosse, Evelyn J. Ellis, Drusano, George L.

“…Our thesis is a simple one: although a drug can fail in an individual patient for many reasons, appropriately sized and conducted drug-development programs…”
Get full text

Pharmacological and Patient-Specific Response Determinants in Patients with Hospital-Acquired Pneumonia Treated with Tigecycline by BHAVNANI, Sujata M, RUBINO, Christopher M, HAMMEL, Jeffrey P, FORREST, Alan, DARTOIS, Nathalie, COOPER, C. Angel, KORTH-BRADLEY, Joan, AMBROSE, Paul G

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Use of Pharmacokinetic-Pharmacodynamic Analyses To Optimize Therapy with the Systemic Antifungal Micafungin for Invasive Candidiasis or Candidemia by ANDES, David, AMBROSE, Paul G, HAMMEL, Jeffrey P, VAN WART, Scott A, IYER, Varsha, REYNOLDS, Daniel K, BUELL, Donald N, KOVANDA, Laura L, BHAVNANI, Sujata M

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Randomized Pharmacokinetic and Pharmacodynamic Comparison of Fluoroquinolones for Tuberculous Meningitis by THWAITES, Guy E, BHAVNANI, Sujata M, TRAN TINH HIEN, KULAWY, Robert, FARRAR, Jeremy, AMBROSE, Paul G, CHAU, Tran Thi Hong, HAMMEL, Jeffrey P, ESTEE TÖRÖK, M, VAN WART, Scott A, PHAM PHUONG MAI, REYNOLDS, Daniel K, CAWS, Maxine, NGUYEN THI DUNG

“…OA  Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

The Pharmacokinetic and Pharmacodynamic Profile of Tigecycline by Meagher, Alison K., Ambrose, Paul G., Grasela, Thaddeus H., Grosse, J. Ellis

“…Tigecycline, a first-in-class expanded-spectrum antimicrobial agent, has demonstrated efficacy in the treatment of complicated intra-abdominal and skin and…”
Get full text

Pharmacokinetics-Pharmacodynamics of Tazobactam in Combination with Ceftolozane in an In Vitro Infection Model by VANSCOY, Brian, MENDES, Rodrigo E, STEENBERGEN, Judith N, AMBROSE, Paul G, NICASIO, Anthony M, CASTANHEIRA, Mariana, BULIK, Catharine C, OKUSANYA, Olanrewaju O, BHAVNANI, Sujata M, FORREST, Alan, JONES, Ronald N, FRIEDRICH, Lawrence V

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Pharmacological Basis of β-Lactamase Inhibitor Therapeutics: Tazobactam in Combination with Ceftolozane by VANSCOY, Brian, MENDES, Rodrigo E, AMBROSE, Paul G, MCCAULEY, Jennifer, BHAVNANI, Sujata M, BULIK, Catharine C, OKUSANYA, Olanrewaju O, FORREST, Alan, JONES, Ronald N, FRIEDRICH, Lawrence V, STEENBERGEN, Judith N

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Back to the Future: Using Aminoglycosides Again and How to Dose Them Optimally by Eliopoulos, George M., Drusano, George L., Ambrose, Paul G., Bhavnani, Sujata M., Bertino, Joseph S., Nafziger, Ann N., Louie, Arnold

“…Gram-negative organisms have become increasingly resistant to both β-lactam antibiotics and fluoroquinolones. Consequently, aminoglycoside antibiotics have…”
Get full text

Isoniazid Bactericidal Activity and Resistance Emergence: Integrating Pharmacodynamics and Pharmacogenomics To Predict Efficacy in Different Ethnic Populations by GUMBO, Tawanda, LOUIE, Arnold, WEIGUO LIU, BROWN, David, AMBROSE, Paul G, BHAVNANI, Sujata M, DRUSANO, George L

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Pharmacokinetic and Pharmacodynamic Evaluation of Liposomal Amikacin for Inhalation in Cystic Fibrosis Patients with Chronic Pseudomonal Infection by OKUSANYA, Olanrewaju O, BHAVNANI, Sujata M, HAMMEL, Jeffrey, MINIC, Predrag, DUPONT, Lieven J, FORREST, Alan, MULDER, Geert-Jan, MACKINSON, Constance, AMBROSE, Paul G, GUPTA, Renu

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Relationship between Ceftolozane-Tazobactam Exposure and Drug Resistance Amplification in a Hollow-Fiber Infection Model by VANSCOY, Brian, MENDES, Rodrigo E, AMBROSE, Paul G, CASTANHEIRA, Mariana, MCCAULEY, Jennifer, BHAVNANI, Sujata M, FORREST, Alan, JONES, Ronald N, OKUSANYA, Olanrewaju O, FRIEDRICH, Lawrence V, STEENBERGEN, Judith

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Pharmacokinetics-Pharmacodynamics of Tigecycline in Patients with Community-Acquired Pneumonia by Rubino, Christopher M, Bhavnani, Sujata M, Forrest, Alan, Dukart, Gary, Dartois, Nathalie, Cooper, Angel, Korth-Bradley, Joan, Ambrose, Paul G

“…Exposure-response analyses for efficacy and safety were performed for tigecycline-treated patients suffering from community-acquired pneumonia. Data were…”
Get full text