Search Results - "Ambros, F."

Advances in Risk Classification and Treatment Strategies for Neuroblastoma by Pinto, Navin R, Applebaum, Mark A, Volchenboum, Samuel L, Matthay, Katherine K, London, Wendy B, Ambros, Peter F, Nakagawara, Akira, Berthold, Frank, Schleiermacher, Gudrun, Park, Julie R, Valteau-Couanet, Dominique, Pearson, Andrew D J, Cohn, Susan L

“…Risk-based treatment approaches for neuroblastoma have been ongoing for decades. However, the criteria used to define risk in various institutional and…”
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Evaluation of Deep Learning Architectures for Complex Immunofluorescence Nuclear Image Segmentation by Kromp, Florian, Fischer, Lukas, Bozsaky, Eva, Ambros, Inge M., Dorr, Wolfgang, Beiske, Klaus, Ambros, Peter F., Hanbury, Allan, Taschner-Mandl, Sabine

“…Separating and labeling each nuclear instance (instance-aware segmentation) is the key challenge in nuclear image segmentation. Deep Convolutional Neural…”
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Schwann cell plasticity regulates neuroblastic tumor cell differentiation via epidermal growth factor-like protein 8 by Weiss, Tamara, Taschner-Mandl, Sabine, Janker, Lukas, Bileck, Andrea, Rifatbegovic, Fikret, Kromp, Florian, Sorger, Helena, Kauer, Maximilian O., Frech, Christian, Windhager, Reinhard, Gerner, Christopher, Ambros, Peter F., Ambros, Inge M.

“…Adult Schwann cells (SCs) possess an inherent plastic potential. This plasticity allows SCs to acquire repair-specific functions essential for peripheral nerve…”
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The International Neuroblastoma Risk Group (INRG) Classification System: An INRG Task Force Report by COHN, Susan L, PEARSON, Andrew D. J, MOSSERI, Veronique, SIMON, Thorsten, GARAVENTA, Alberto, CASTEL, Victoria, MATTHAY, Katherine K, LONDON, Wendy B, MONCLAIR, Tom, AMBROS, Peter F, BRODEUR, Garrett M, FALDUM, Andreas, HERO, Barbara, IEHARA, Tomoko, MACHIN, David

“…Because current approaches to risk classification and treatment stratification for children with neuroblastoma (NB) vary greatly throughout the world, it is…”
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Clinical, biologic, and prognostic differences on the basis of primary tumor site in neuroblastoma: a report from the international neuroblastoma risk group project by Vo, Kieuhoa T, Matthay, Katherine K, Neuhaus, John, London, Wendy B, Hero, Barbara, Ambros, Peter F, Nakagawara, Akira, Miniati, Doug, Wheeler, Kate, Pearson, Andrew D J, Cohn, Susan L, DuBois, Steven G

“…Neuroblastoma (NB) is a heterogeneous tumor arising from sympathetic tissues. The impact of primary tumor site in influencing the heterogeneity of NB remains…”
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Spatial and temporal intratumour heterogeneity has potential consequences for single biopsy-based neuroblastoma treatment decisions by Schmelz, Karin, Toedling, Joern, Huska, Matt, Cwikla, Maja C., Kruetzfeldt, Louisa-Marie, Proba, Jutta, Ambros, Peter F., Ambros, Inge M., Boral, Sengül, Lodrini, Marco, Chen, Celine Y., Burkert, Martin, Guergen, Dennis, Szymansky, Annabell, Astrahantseff, Kathy, Kuenkele, Annette, Haase, Kerstin, Fischer, Matthias, Deubzer, Hedwig E., Hertwig, Falk, Hundsdoerfer, Patrick, Henssen, Anton G., Schwarz, Roland F., Schulte, Johannes H., Eggert, Angelika

“…Intratumour heterogeneity is a major cause of treatment failure in cancer. We present in-depth analyses combining transcriptomic and genomic profiling with…”
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Clinical and Biologic Features Predictive of Survival After Relapse of Neuroblastoma: A Report From the International Neuroblastoma Risk Group Project by LONDON, Wendy B, CASTEL, Victoria, MATTHAY, Katherine K, MONCLAIR, Tom, AMBROS, Peter F, PEARSON, Andrew D. J, COHN, Susan L, BERTHOLD, Frank, NAKAGAWARA, Akira, LADENSTEIN, Ruth L, IEHARA, Tomoko

“…Survival after neuroblastoma relapse is poor. Understanding the relationship between clinical and biologic features and outcome after relapse may help in…”
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The International Neuroblastoma Risk Group (INRG) Staging System: An INRG Task Force Report by MONCLAIR, Tom, BRODEUR, Garrett M, VON SCHWEINITZ, Dietrich, SIMON, Thorsten, COHN, Susan L, PEARSON, Andrew D. J, AMBROS, Peter F, BRISSE, Hervé J, CECCHETTO, Giovanni, HOLMES, Keith, KANEKO, Michio, LONDON, Wendy B, MATTHAY, Katherine K, NUCHTERN, Jed G

“…The International Neuroblastoma Risk Group (INRG) classification system was developed to establish a consensus approach for pretreatment risk stratification…”
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Sensitive Detection of Mono- and Polyclonal ESR1 Mutations in Primary Tumors, Metastatic Lesions, and Cell-Free DNA of Breast Cancer Patients by Wang, Peilu, Bahreini, Amir, Gyanchandani, Rekha, Lucas, Peter C, Hartmaier, Ryan J, Watters, Rebecca J, Jonnalagadda, Amruth R, Trejo Bittar, Humberto E, Berg, Aaron, Hamilton, Ronald L, Kurland, Brenda F, Weiss, Kurt R, Mathew, Aju, Leone, Jose Pablo, Davidson, Nancy E, Nikiforova, Marina N, Brufsky, Adam M, Ambros, Tadeu F, Stern, Andrew M, Puhalla, Shannon L, Lee, Adrian V, Oesterreich, Steffi

“…Given the clinical relevance of ESR1 mutations as potential drivers of resistance to endocrine therapy, this study used sensitive detection methods to…”
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Genomic Amplifications and Distal 6q Loss: Novel Markers for Poor Survival in High-risk Neuroblastoma Patients by Depuydt, Pauline, Boeva, Valentina, Hocking, Toby D, Cannoodt, Robrecht, Ambros, Inge M, Ambros, Peter F, Asgharzadeh, Shahab, Attiyeh, Edward F, Combaret, Valérie, Defferrari, Raffaella, Fischer, Matthias, Hero, Barbara, Hogarty, Michael D, Irwin, Meredith S, Koster, Jan, Kreissman, Susan, Ladenstein, Ruth, Lapouble, Eve, Laureys, Geneviève, London, Wendy B, Mazzocco, Katia, Nakagawara, Akira, Noguera, Rosa, Ohira, Miki, Park, Julie R, Pötschger, Ulrike, Theissen, Jessica, Tonini, Gian Paolo, Valteau-Couanet, Dominique, Varesio, Luigi, Versteeg, Rogier, Speleman, Frank, Maris, John M, Schleiermacher, Gudrun, De Preter, Katleen

“…Neuroblastoma is characterized by substantial clinical heterogeneity. Despite intensive treatment, the survival rates of high-risk neuroblastoma patients are…”
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Proteomics and transcriptomics of peripheral nerve tissue and cells unravel new aspects of the human Schwann cell repair phenotype by Weiss, Tamara, Taschner-Mandl, Sabine, Bileck, Andrea, Slany, Astrid, Kromp, Florian, Rifatbegovic, Fikret, Frech, Christian, Windhager, Reinhard, Kitzinger, Hugo, Tzou, Chieh-Han, Ambros, Peter F., Gerner, Christopher, Ambros, Inge M.

“…The remarkable feature of Schwann cells (SCs) to transform into a repair phenotype turned the spotlight on this powerful cell type. SCs provide the…”
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Amplification of CDK4 and MDM2: a detailed study of a high-risk neuroblastoma subgroup by Martinez-Monleon, Angela, Kryh Öberg, Hanna, Gaarder, Jennie, Berbegall, Ana P., Javanmardi, Niloufar, Djos, Anna, Ussowicz, Marek, Taschner-Mandl, Sabine, Ambros, Inge M., Øra, Ingrid, Sandstedt, Bengt, Beiske, Klaus, Ladenstein, Ruth, Noguera, Rosa, Ambros, Peter F., Gordon Murkes, Lena, Ljungman, Gustaf, Kogner, Per, Fransson, Susanne, Martinsson, Tommy

“…In neuroblastoma, MYCN amplification and 11q-deletion are important, although incomplete, markers of high-risk disease. It is therefore relevant to…”
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latent human herpesvirus-6A genome specifically integrates in telomeres of human chromosomes in vivo and in vitro by Arbuckle, Jesse H, Medveczky, Maria M, Luka, Janos, Hadley, Stephen H, Luegmayr, Andrea, Ablashi, Dharam, Lund, Troy C, Tolar, Jakub, De Meirleir, Kenny, Montoya, Jose G, Komaroff, Anthony L, Ambros, Peter F, Medveczky, Peter G

“…Previous research has suggested that human herpesvirus-6 (HHV-6) may integrate into host cell chromosomes and be vertically transmitted in the germ line, but…”
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Chromosomally integrated human herpesvirus 6: questions and answers by Pellett, Philip E., Ablashi, Dharam V., Ambros, Peter F., Agut, Henri, Caserta, Mary T., Descamps, Vincent, Flamand, Louis, Gautheret-Dejean, Agnès, Hall, Caroline B., Kamble, Rammurti T., Kuehl, Uwe, Lassner, Dirk, Lautenschlager, Irmeli, Loomis, Kristin S., Luppi, Mario, Lusso, Paolo, Medveczky, Peter G., Montoya, Jose G., Mori, Yasuko, Ogata, Masao, Pritchett, Joshua C., Rogez, Sylvie, Seto, Edward, Ward, Katherine N., Yoshikawa, Tetsushi, Razonable, Raymund R.

“…SUMMARY Chromosomally integrated human herpesvirus 6 (ciHHV‐6) is a condition in which the complete HHV‐6 genome is integrated into the host germ line genome…”
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Gene amplification as double minutes or homogeneously staining regions in solid tumors: origin and structure by Storlazzi, Clelia Tiziana, Lonoce, Angelo, Guastadisegni, Maria C, Trombetta, Domenico, D'Addabbo, Pietro, Daniele, Giulia, L'Abbate, Alberto, Macchia, Gemma, Surace, Cecilia, Kok, Klaas, Ullmann, Reinhard, Purgato, Stefania, Palumbo, Orazio, Carella, Massimo, Ambros, Peter F, Rocchi, Mariano

“…Double minutes (dmin) and homogeneously staining regions (hsr) are the cytogenetic hallmarks of genomic amplification in cancer. Different mechanisms have been…”
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Busulfan and melphalan versus carboplatin, etoposide, and melphalan as high-dose chemotherapy for high-risk neuroblastoma (HR-NBL1/SIOPEN): an international, randomised, multi-arm, open-label, phase 3 trial by Ladenstein, Ruth, Prof, Pötschger, Ulrike, MSc, Pearson, Andrew D J, Prof, Brock, Penelope, MD, Luksch, Roberto, MD, Castel, Victoria, MD, Yaniv, Isaac, Prof, Papadakis, Vassilios, MD, Laureys, Geneviève, MD, Malis, Josef, MD, Balwierz, Walentyna, Prof, Ruud, Ellen, MD, Kogner, Per, Prof, Schroeder, Henrik, Prof, de Lacerda, Ana Forjaz, MD, Beck-Popovic, Maja, MD, Bician, Pavel, MD, Garami, Miklós, MD, Trahair, Toby, MD, Canete, Adela, MD, Ambros, Peter F, PhD, Holmes, Keith, MD, Gaze, Mark, MD, Schreier, Günter, PhD, Garaventa, Alberto, MD, Vassal, Gilles, Prof, Michon, Jean, MD, Valteau-Couanet, Dominique, MD

“…Summary Background High-dose chemotherapy with haemopoietic stem-cell rescue improves event-free survival in patients with high-risk neuroblastoma; however,…”
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Redirecting T cells to Ewing's sarcoma family of tumors by a chimeric NKG2D receptor expressed by lentiviral transduction or mRNA transfection by Lehner, Manfred, Götz, Gabriel, Proff, Julia, Schaft, Niels, Dörrie, Jan, Full, Florian, Ensser, Armin, Muller, Yves A, Cerwenka, Adelheid, Abken, Hinrich, Parolini, Ornella, Ambros, Peter F, Kovar, Heinrich, Holter, Wolfgang

“…We explored the possibility to target Ewing's sarcoma family of tumors (ESFT) by redirecting T cells. To this aim, we considered NKG2D-ligands (NKG2D-Ls) as…”
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FKHRL1-mediated expression of Noxa and Bim induces apoptosis via the mitochondria in neuroblastoma cells by Obexer, P, Geiger, K, Ambros, P F, Meister, B, Ausserlechner, M J

“…Protein kinase-B (PKB) and its target, the forkhead transcription factor like 1 (FKHRL1)/FoxO3a, have been suggested as regulators of neurotrophin-mediated…”
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Neuroblastoma in older children, adolescents and young adults: A report from the International Neuroblastoma Risk Group project by Mossé, Yaël P., Deyell, Rebecca J., Berthold, Frank, Nagakawara, Akira, Ambros, Peter F., Monclair, Tom, Cohn, Susan L., Pearson, Andrew D., London, Wendy B., Matthay, Katherine K.

“…Background Neuroblastoma in older children and adolescents has a distinctive, indolent phenotype, but little is known about the clinical and biological…”
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Circulating Breast Cancer Cells Are Frequently Apoptotic by Méhes, Gábor, Witt, Armin, Kubista, Ernst, Ambros, Peter F.

“…Automatic search for cytokeratin/mucin-1 double immunofluorescence was performed to detect and characterize circulating epithelial tumor cells in patients with…”
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