Search Results - "Ambre, Premlata K."

New horizons in antimalarial drug discovery in the last decade by chemoinformatic approaches by Ambre, Premlata K, Wavhale, Ravindra D, Coutinho, Evans C

“…Antimalarial drug discovery process is progressively carried out by a combination of innovation and knowledge based methods that include computational and…”
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Novel derivatives of arabinogalactan, pullulan & lactobionic acid for targeting asialoglycoprotein receptor: Biomolecular interaction, synthesis & evaluation by Warrier, Deepa U., Dhanabalan, Anantha K., Krishnasamy, Gunasekaran, Kolge, Henry, Ghormade, Vandana, Gupta, Chandan R., Ambre, Premlata K., Shinde, Ujwala A.

“…Targeted-drug administration to liver reduces side effects by minimising drug distribution to non-target organs and increases therapeutic efficacy by boosting…”
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Discovery of new leads against Mycobacterium tuberculosis using scaffold hopping and shape based similarity by Wavhale, Ravindra D., Martis, Elvis A.F., Ambre, Premlata K., Wan, Baojie, Franzblau, Scott G., Iyer, Krishna R., Raikuvar, Kavita, Macegoniuk, Katarzyna, Berlicki, Łukasz, Nandan, Santosh R., Coutinho, Evans C.

“…[Display omitted] BM212 [1,5-diaryl-2-methyl-3-(4-methylpiperazin-1-yl)-methyl-pyrrole] is a pyrrole derivative with strong inhibitory activity against drug…”
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Extracting structural requirements for activity of GPR119 agonists: a hologram quantitative structure activity relationship (HQSAR) study by Ugarkar, Apoorva G, Ambre, Premlata K, Coutinho, Evans C, Nandan, Santosh, Pissurlenkar, Raghuvir R.S

“…GPR119 is a potential target for the treatment of diabetes mellitus. GPR119 agonists minimize the side-effects observed with sulphonyl ureas and glucagon-like…”
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Quantifying ligand-receptor interactions for gorge-spanning acetylcholinesterase inhibitors for the treatment of Alzheimer's disease by Martis, Elvis A.F., Chandarana, Rakesh C., Shaikh, Mushtaque S., Ambre, Premlata K., D'Souza, Jacinta S., Iyer, Krishna R., Coutinho, Evans C., Nandan, Santosh R., Pissurlenkar, Raghuvir R.S.

“…There is a need for continued development of acetylcholinesterase (AChE) inhibitors that could prolong the life of acetylcholine in the synaptic cleft and also…”
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Identification of new checkpoint kinase-1 (Chk1) inhibitors by docking, 3D-QSAR, and pharmacophore-modeling methods by Ambre, Premlata K, Pissurlenkar, Raghuvir R.S, Coutinho, Evans C, Iyer, Radhakrishnan P

“…Inhibition of checkpoint kinase-1 (Chk1) by small molecules is of great therapeutic interest in the field of oncology and for understanding cell-cycle…”
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Molecular docking and 3D-QSAR studies of HIV-1 protease inhibitors by Khedkar, Vijay M., Ambre, Premlata K., Verma, Jitender, Shaikh, Mushtaque S., Pissurlenkar, Raghuvir R. S., Coutinho, Evans C.

“…HIV-1 protease is an obligatory enzyme in the replication process of the HIV virus. The abundance of structural information on HIV-1PR has made the enzyme an…”
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Antifolate agents against wild and mutant strains of plasmodium falciparum by Shaikh, M, Rana, J, Gaikwad, D, Leartsakulpanich, U, Ambre, Premlata, Pissurlenkar, R. R. S, Coutinho, E

“…Plasmodium falciparum dihydrofolate reductase is an important target for antimalarial chemotherapy. The emergence of resistance has significantly reduced the…”
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Design, Synthesis and Evaluation of Novel 1-(Substituted Acetyl)-4-(10-Bromo-8-Chloro-5,6-Dihydro-11H-Benzo[5,6]Cyclohepta[1,2-B]Pyridine-11-Ylidene)piperidines as Antitumor Agents and Farnesyl Protein Transferase Inhibitors by Gatne, P S, Viswanathan, C L, Ambre, Premlata K, Juvekar, Aarti

“…Eight novel 1-(substituted acetyl)-4-(10-bromo-8-chloro-5,6-dihydro-11H-benzo[5,6] cyclohepta [1,2-b] pyridine-11-ylidene)piperidines were designed by…”
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Design, synthesis, and evaluation of 4-(substituted)phenyl-2-thioxo-3,4-dihydro-1H-chromino[4,3-d]pyrimidin-5-one and 4-(substituted)phenyl-3,4-dihydro-1H-chromino[4,3-d]pyrimidine-2,5-dione analogs as antitubercular agents by Ambre, Premlata K., Pissurlenkar, Raghuvir R. S., Wavhale, Ravindra D., Shaikh, Mushtaque S., Khedkar, Vijay M., Wan, Baojie, Franzblau, Scott G., Coutinho, Evans C.

“…This paper focuses on the design and antitubercular activity of molecules which are a hybrid of coumarin and pyrimidine nuclei. A set of 16 compounds, viz…”
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Quantifying ligand-receptor interactions for gorge-spanning acetylcholinesterase inhibitors for the treatment of Alzheimer' disease by Martis, Elvis AF, Chandarana, Rakesh C, Shaikh, Mushtaque S, Ambre, Premlata K, D'Souza, Jacinta S, Iyer, Krishna R, Coutinho, Evans C, Nandan, Santosh R, Pissurlenkar, Raghuvir RS

“…There is a need for continued development of acetylcholinesterase (AChE) inhibitors that could prolong the life of acetylcholine in the synaptic cleft and also…”
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