Search Results - "Ambhore, Nilesh Sudhakar"

Role of Differential Estrogen Receptor Activation in Airway Hyperreactivity and Remodeling in a Murine Model of Asthma by Ambhore, Nilesh Sudhakar, Kalidhindi, Rama Satyanarayana Raju, Loganathan, Jagadish, Sathish, Venkatachalem

“…Evidence suggests that airway hyperresponsiveness (AHR) is a characteristic feature of asthma. Epidemiological studies have confirmed that the severity of…”
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Kisspeptin regulates airway hyperresponsiveness and remodeling in a mouse model of asthma by Borkar, Niyati A, Ambhore, Nilesh Sudhakar, Balraj, Premanand, Ramakrishnan, Yogaraj S, Sathish, Venkatachalem

“…Asthma is a multifactorial disease of origin characterized by airway hyperresponsiveness (AHR) and airway remodeling. Several pieces of evidence from other…”
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Laser-capture microdissection of murine lung for differential cellular RNA analysis by Loganathan, Jagadish, Pandey, Roshni, Ambhore, Nilesh Sudhakar, Borowicz, Pawel, Sathish, Venkatachalem

“…The lung tissue contains a heterogeneous milieu of bronchioles, epithelial, airway smooth muscle (ASM), alveolar, and immune cell types. Healthy bronchiole…”
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Role of Estrogen Receptors α and β in a Murine Model of Asthma: Exacerbated Airway Hyperresponsiveness and Remodeling in ERβ Knockout Mice by Kalidhindi, Rama Satyanarayana Raju, Ambhore, Nilesh Sudhakar, Bhallamudi, Sangeeta, Loganathan, Jagadish, Sathish, Venkatachalem

“…Epidemiological data suggests increased prevalence of asthma in females than males, suggesting a plausible role for sex-steroids, especially estrogen in the…”
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Kiss1 receptor knockout exacerbates airway hyperresponsiveness and remodeling in a mouse model of allergic asthma by Ambhore, Nilesh Sudhakar, Balraj, Premanand, Kumar, Ashish, Reza, Mohammad Irshad, Ramakrishnan, Yogaraj S, Tesch, Jacob, Lohana, Sahil, Sathish, Venkatachalem

“…In asthma, sex-steroids signaling is recognized as a critical regulator of disease pathophysiology. However, the paradoxical role of sex-steroids, especially…”
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Network and co-expression analysis of airway smooth muscle cell transcriptome delineates potential gene signatures in asthma by Banerjee, Priyanka, Balraj, Premanand, Ambhore, Nilesh Sudhakar, Wicher, Sarah A., Britt, Rodney D., Pabelick, Christina M., Prakash, Y. S., Sathish, Venkatachalem

“…Airway smooth muscle (ASM) is known for its role in asthma exacerbations characterized by acute bronchoconstriction and remodeling. The molecular mechanisms…”
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Editorial: Evolution in respiratory pharmacology by Ruaro, Barbara, Pozzan, Riccardo, Andrisano, Alessia Giovanna, Confalonieri, Marco, Ambhore, Nilesh Sudhakar

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Kisspeptins inhibit human airway smooth muscle proliferation by Borkar, Niyati A, Ambhore, Nilesh Sudhakar, Kalidhindi, Rama Satyanarayana Raju, Pabelick, Christina M, Prakash, Y S, Sathish, Venkatachalem

“…Sex and gender disparity in asthma is recognized and suggests a modulatory role for sex steroids, particularly estrogen. However, there is a dichotomous role…”
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Determination of Histamine H3-Receptor Antagonist Conessine in Wistar Rat Plasma by a Rapid and Sensitive RP-UFLC Method: Application to a Pharmacokinetic Study by Ambhore, Nilesh Sudhakar, Kalidhindi, Rama Satyanarayana Raju, Mohire, Shubhashri, Yamjala, Karthik, Mulukutla, Shashank, Murthy, Vishakantha, Thondawada, Mahesh, Elango, Kannan

“…Objectives: Epidemiological data suggests the highest density of histamine H3-receptors (H3R) in basal ganglia of central nervous system (CNS) wherein they…”
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Sex-Steroid Signaling in Lung Diseases and Inflammation by Ambhore, Nilesh Sudhakar, Kalidhindi, Rama Satyanarayana Raju, Sathish, Venkatachalem

“…Sex/gender difference exists in the physiology of multiple organs. Recent epidemiological reports suggest the influence of sex-steroids in modulating a wide…”
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Cellular and Biochemical Analysis of Bronchoalveolar Lavage Fluid from Murine Lungs by Kalidhindi, Rama Satyanarayana Raju, Ambhore, Nilesh Sudhakar, Sathish, Venkatachalem

“…Bronchoalveolar lavage (BAL) is a technique used to collect the contents of the airways. The fluid recovered, called BAL fluid (BALF), serves as a dynamic tool…”
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Sex steroids skew ACE2 expression in human airway: a contributing factor to sex differences in COVID-19? by Kalidhindi, Rama Satyanarayana Raju, Borkar, Niyati A, Ambhore, Nilesh Sudhakar, Pabelick, Christina M, Prakash, Y S, Sathish, Venkatachalem

“…The incidence, severity, and mortality of ongoing coronavirus infectious disease 19 (COVID-19) is greater in men compared with women, but the underlying…”
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Molecular determinants of airway smooth muscle cells in health and disease by Ambhore, Nilesh Sudhakar, Kumar, Ashish, Sathish, Venkatachalem

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Androgen receptor activation alleviates airway hyperresponsiveness, inflammation, and remodeling in a murine model of asthma by Kalidhindi, Rama Satyanarayana Raju, Ambhore, Nilesh Sudhakar, Balraj, Premanand, Schmidt, Taylor, Khan, M Nadeem, Sathish, Venkatachalem

“…Epidemiological studies demonstrate an apparent sex-based difference in the prevalence of asthma, with a higher risk in boys than girls, which is reversed…”
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Differential estrogen‐receptor activation regulates extracellular matrix deposition in human airway smooth muscle remodeling via NF‐κB pathway by Ambhore, Nilesh Sudhakar, Kalidhindi, Rama Satyanarayana Raju, Pabelick, Christina M., Hawse, John R., Prakash, Y. S., Sathish, Venkatachalem

“…Altered airway smooth muscle (ASM) mass and extracellular matrix (ECM) deposition in airways are characteristic features of remodeling in asthma. Increased ECM…”
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Estrogen receptors differentially modifies lamellipodial and focal adhesion dynamics in airway smooth muscle cell migration by Ambhore, Nilesh Sudhakar, Balraj, Premanand, Pabelick, Christina M, Prakash, Y S, Sathish, Venkatachalem

“…Sex-steroid signaling, especially estrogen, has a paradoxical impact on regulating airway remodeling. In our previous studies, we demonstrated differential…”
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Estrogen Receptors Differentially Regulate the Overall Contractility of Human Airway Smooth Muscle by Bhallamudi, Sangeeta, Ambhore, Nilesh Sudhakar, Saladi, Swetha, Pabelick, Christina M., Prakash, Y.S., Sathish, Venkatachalem

“…Abstract only Purpose Epidemiological evidences suggest higher incidence and severity of asthma in pre‐menopausal women and aging men, indicating the role of…”
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Estrogen receptor beta signaling inhibits PDGF induced human airway smooth muscle proliferation by Ambhore, Nilesh Sudhakar, Katragadda, Rathnavali, Raju Kalidhindi, Rama Satyanarayana, Thompson, Michael A., Pabelick, Christina M., Prakash, Y.S., Sathish, Venkatachalem

“…Airway smooth muscle (ASM) cell hyperplasia driven by persistent inflammation is a hallmark feature of remodeling in asthma. Sex steroid signaling in the lungs…”
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Kisspeptin/KISS1R Signaling Modulates Human Airway Smooth Muscle Cell Migration by Balraj, Premanand, Ambhore, Nilesh Sudhakar, Ramakrishnan, Yogaraj S, Borkar, Niyati A, Banerjee, Priyanka, Reza, Mohammad Irshad, Varadharajan, Subashini, Kumar, Ashish, Pabelick, Christina M, Prakash, Y S, Sathish, Venkatachalem

“…Airway remodeling is a cardinal feature of asthma, associated with increased airway smooth muscle (ASM) cell mass and upregulation of extracellular matrix…”
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Pharmacokinetic and tissue distribution studies of 1,9-pyrazoloanthrone, a c-Jun-N-terminal kinase inhibitor in Wistar rats by a simple and sensitive HPLC method by Ambhore, Nilesh Sudhakar, Yamjala, Karthik, Mohire, Shubhashri, Raju, Kalidhindi Rama Satyanarayana, Mulukutla, Shashank, Murthy, Vishakantha, Tondhawada, Mahesh, Elango, Kannan

“…[Display omitted] •The HPLC method was developed and validated.•This method was successfully applied to pharmacokinetic and tissue distribution study in Wistar…”
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