Search Results - "Amberg, Gregory C"

AXL/Gas6 signaling mechanisms in the hypothalamic-pituitary-gonadal axis by Mohammadzadeh, Pardis, Amberg, Gregory C

“…AXL is a receptor tyrosine kinase commonly associated with a variety of human cancers. Along with its ligand Gas6 (growth arrest-specific protein 6), AXL is…”
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Calcium Dynamics in Vascular Smooth Muscle by Amberg, Gregory C., Navedo, Manuel F.

“…Smooth muscle cells are ultimately responsible for determining vascular luminal diameter and blood flow. Dynamic changes in intracellular calcium are a…”
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AXL receptor tyrosine kinase modulates gonadotropin-releasing hormone receptor signaling by Mohammadzadeh, Pardis, Roueinfar, Mina, Amberg, Gregory C

“…Gonadotropin-releasing hormone (GnRH) receptors are essential for reproduction and are expressed in numerous urogenital, reproductive, and non-reproductive…”
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Pharmacological inhibition of TRPM4 hyperpolarizes vascular smooth muscle by Gonzales, Albert L, Garcia, Zarine I, Amberg, Gregory C, Earley, Scott

“…The contractile state of vascular smooth muscle cells is regulated by small changes in membrane potential that gate voltage-dependent calcium channels. The…”
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Local Regulation of Arterial L-Type Calcium Channels by Reactive Oxygen Species by Amberg, Gregory C, Earley, Scott, Glapa, Stephanie A

“…RATIONALE:Reactive oxygen species (ROS) are implicated in the development of cardiovascular disease, and oxidants are important signaling molecules in many…”
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Downregulation of the BK Channel β1 Subunit in Genetic Hypertension by Amberg, Gregory C, Santana, L Fernando

“…ABSTRACT—The molecular mechanisms underlying increased arterial tone during hypertension are unclear. In vascular smooth muscle, localized Ca release events…”
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AKAP150 Is Required for Stuttering Persistent Ca2+ Sparklets and Angiotensin II–Induced Hypertension by Navedo, Manuel F, Nieves-Cintrón, Madeline, Amberg, Gregory C, Yuan, Can, Votaw, V Scott, Lederer, W Jonathan, McKnight, G Stanley, Santana, Luis F

“…Hypertension is a perplexing multiorgan disease involving renal primary pathology and enhanced angiotensin II vascular reactivity. Here, we report that a novel…”
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Activation of NFATc3 Down-regulates the β1 Subunit of Large Conductance, Calcium-activated K+ Channels in Arterial Smooth Muscle and Contributes to Hypertension by Nieves-Cintrón, Madeline, Amberg, Gregory C., Nichols, C. Blake, Molkentin, Jeffery D., Santana, Luis F.

“…Large conductance, Ca2+-activated K+ (BK) channels modulate the excitability and contractile state of arterial smooth muscle. Recently, we demonstrated that…”
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Kv2 channels oppose myogenic constriction of rat cerebral arteries by Amberg, Gregory C, Santana, Luis F

“…By hyperpolarizing arterial smooth muscle, voltage-gated, Ca2+-independent K+ (Kv) channels decrease calcium influx and thus oppose constriction. However, the…”
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Constitutively Active L-Type Ca2+Channels by Navedo, Manuel F., Amberg, Gregory C., Votaw, V. Scott, Santana, Luis F., Jan, Lily Y.

“…Ca2+influx through L-type Ca2+channels (LTCCs) influences numerous physiological processes ranging from contraction in muscle and memory in neurons to gene…”
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control of Ca²⁺ influx and NFATc3 signaling in arterial smooth muscle during hypertension by Nieves-Cintrón, Madeline, Amberg, Gregory C, Navedo, Manuel F, Molkentin, Jeffery D, Santana, Luis F

“…Many excitable cells express L-type Ca²⁺ channels (LTCCs), which participate in physiological and pathophysiological processes ranging from memory, secretion,…”
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Dynamin Is Required for GnRH Signaling to L-Type Calcium Channels and Activation of ERK by Edwards, Brian S, Dang, An K, Murtazina, Dilyara A, Dozier, Melissa G, Whitesell, Jennifer D, Khan, Shaihla A, Cherrington, Brian D, Amberg, Gregory C, Clay, Colin M, Navratil, Amy M

“…We have shown that GnRH-mediated engagement of the cytoskeleton induces cell movement and is necessary for ERK activation. It also has previously been…”
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Mechanisms underlying heterogeneous Ca2+ sparklet activity in arterial smooth muscle by Navedo, Manuel F, Amberg, Gregory C, Nieves, Madeline, Molkentin, Jeffery D, Santana, Luis F

“…In arterial smooth muscle, single or small clusters of Ca(2+) channels operate in a high probability mode, creating sites of nearly continual Ca(2+) influx…”
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Calcium sparklets regulate local and global calcium in murine arterial smooth muscle by Amberg, Gregory C., Navedo, Manuel F., Nieves‐Cintrón, Madeline, Molkentin, Jeffery D., Santana, Luis F.

“…In arterial smooth muscle, protein kinase Cα (PKCα) coerces discrete clusters of L-type Ca 2+ channels to operate in a high open probability mode, resulting…”
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NFATc3 Regulates Kv2.1 Expression in Arterial Smooth Muscle by Amberg, Gregory C, Rossow, Charles F, Navedo, Manuel F, Santana, Luis F

“…Voltage-gated K + (Kv) channels control the excitability of arterial smooth muscle. However, the molecular mechanisms regulating Kv channel function in smooth…”
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Stimulation of arterial smooth muscle L-type calcium channels by hydrogen peroxide requires protein kinase C by Chaplin, Nathan L., Amberg, Gregory C.

“…Changes in intracellular calcium regulate countless biological processes. In arterial smooth muscle, voltage-dependent L-type calcium channels are major…”
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Reactive Oxygen Species Modulate Activity-Dependent AMPA Receptor Transport in C. elegans by Doser, Rachel L, Amberg, Gregory C, Hoerndli, Frederic J

“…The AMPA subtype of synaptic glutamate receptors (AMPARs) plays an essential role in cognition. Their function, numbers, and change at synapses during synaptic…”
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Characterization of the A-type potassium current in murine gastric fundus smooth muscles by Amberg, Gregory C, Lee, Ji Yeon, Koh, Sang Don, Sanders, Kenton M

“…Transient outward, or "A-type," currents are rapidly inactivating voltage-gated potassium currents that operate at negative membrane potentials. A-type…”
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CALCIUM SPARKLETS IN ARTERIAL SMOOTH MUSCLE by Santana, Luis F, Navedo, Manuel F, Amberg, Gregory C, Nieves-Cintrón, Madeline, Votaw, V Scott, Ufret-Vincenty, Carmen A

“…SUMMARY 1 Voltage‐dependent, L‐type Ca2+ channels (LTCC) play an essential role in arterial smooth muscle contraction and, consequently, the regulation of…”
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Ca2+ release from the sarcoplasmic reticulum is required for sustained TRPM4 activity in cerebral artery smooth muscle cells by Gonzales, Albert L, Amberg, Gregory C, Earley, Scott

“…The melastatin transient receptor potential (TRP) channel TRPM4 is a critical regulator of vascular smooth muscle cell membrane potential and contractility…”
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