Search Results - "Ambati, Balamurali K."

The value of nutritional supplements in treating Age-Related Macular Degeneration: a review of the literature by Mukhtar, Sabrina, Ambati, Balamurali K.

“…Purpose To describe and evaluate the value of nutritional supplements in the management of age-related macular degeneration (AMD) through a review of the…”
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Neurodegeneration severity can be predicted from early microglia alterations monitored in vivo in a mouse model of chronic glaucoma by Bosco, Alejandra, Romero, Cesar O, Breen, Kevin T, Chagovetz, Alexis A, Steele, Michael R, Ambati, Balamurali K, Vetter, Monica L

“…Microglia serve key homeostatic roles, and respond to neuronal perturbation and decline with a high spatiotemporal resolution. The course of all chronic CNS…”
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Chronic Dicer1 deficiency promotes atrophic and neovascular outer retinal pathologies in mice by Wright, Charles B., Uehara, Hironori, Kim, Younghee, Yasuma, Tetsuhiro, Yasuma, Reo, Hirahara, Shuichiro, Makin, Ryan D., Apicella, Ivana, Pereira, Felipe, Nagasaka, Yosuke, Narendran, Siddharth, Fukuda, Shinichi, Albuquerque, Romulo, Fowler, Benjamin J., Bastos-Carvalho, Ana, Georgel, Philippe, Hatada, Izuho, Chang, Bo, Kerur, Nagaraj, Ambati, Balamurali K., Ambati, Jayakrishna, Gelfand, Bradley D.

“…Degeneration of the retinal pigmented epithelium (RPE) and aberrant blood vessel growth in the eye are advanced-stage processes in blinding diseases such as…”
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Horizons in Therapy for Corneal Angiogenesis by Maddula, Surekha, MD, Davis, Don K., MD, Maddula, Soumya, BA, Burrow, Michael K., BA, Ambati, Balamurali K., MD, PhD

“…Corneal neovascularization can lead to a devastating disease process that involves the breakdown of the limbal barrier and the formation of blood vessels in…”
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Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth by Dridi, Sami, Hirashima, Masanori, Albuquerque, Romulo J C, Cho, Won Gil, Kleinman, Mark E, Capoor, Seema, Baffi, Judit Z, Peterson, Martha L, Kaneko, Hiroki, Amano, Shiro, Chappell, Joe, Wilting, Jörg, Ambati, Jayakrishna, Takeda, Atsunobu, Yamada, Kiyoshi, Mizuki, Nobuhisa, Weich, Herbert A, Green, Martha G, Ambati, Balamurali K, Alexander, Jonathan S, Usui, Tomohiko, Brekken, Rolf A, Yamagami, Satoru, Hayashi, Takahiko

“…Although endogenous inhibitors of blood vessel growth have been studied extensively, specific inhibitors of lymphatic vessel growth have not been identified…”
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DICER1/Alu RNA dysmetabolism induces Caspase-8–mediated cell death in age-related macular degeneration by Kim, Younghee, Tarallo, Valeria, Kerur, Nagaraj, Yasuma, Tetsuhiro, Gelfand, Bradley D., Bastos-Carvalho, Ana, Hirano, Yoshio, Yasuma, Reo, Mizutani, Takeshi, Fowler, Benjamin J., Li, Shengjian, Kaneko, Hiroki, Bogdanovich, Sasha, Ambati, Balamurali K., Hinton, David R., Hauswirth, William W., Hakem, Razqallah, Wright, Charles, Ambati, Jayakrishna

“…Significance Geographic atrophy is a late stage of age-related macular degeneration (AMD) that causes blindness in millions worldwide characterized by death of…”
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Efficacy of haptic sutured in-the-bag intraocular lens for intraocular lens-capsule complex stability: a comparison of three insertion methods by Cho, Yang Kyung, Ambati, Balamurali K

“…AIM: To evaluate the efficacy and stability of haptic sutured in-the-bag intraocular lens (IOL) in eyes with zonular instability. METHODS: A total 60 eyes of…”
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Drusen Complement Components C3a and C5a Promote Choroidal Neovascularization by Nozaki, Miho, Raisler, Brian J., Sakurai, Eiji, Sarma, J. Vidya, Barnum, Scott R., Lambris, John D., Chen, Yali, Zhang, Kang, Ambati, Balamurali K., Baffi, Judit Z., Ambati, Jayakrishna

“…Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in industrialized nations, affecting 30-50 million people worldwide. The…”
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Soluble vascular endothelial growth factor receptor 3 is essential for corneal alymphaticity by Singh, Nirbhai, Tiem, Michelle, Watkins, Ryan, Cho, Yang Kyung, Wang, Ying, Olsen, Thomas, Uehara, Hironori, Mamalis, Christina, Luo, Ling, Oakey, Zackery, Ambati, Balamurali K.

“…Corneal transparency is a prerequisite for optimal vision and in turn relies on an absence of blood and lymphatic vessels, which is remarkable given the…”
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Macrophage Depletion Inhibits Experimental Choroidal Neovascularization by Sakurai, Eiji, Anand, Akshay, Ambati, Balamurali K, van Rooijen, Nico, Ambati, Jayakrishna

“…To investigate the role of macrophages in the development of laser-induced choroidal neovascularization (CNV) by selective depletion with liposomal clodronate…”
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Start codon disruption with CRISPR/Cas9 prevents murine Fuchs' endothelial corneal dystrophy by Uehara, Hironori, Zhang, Xiaohui, Pereira, Felipe, Narendran, Siddharth, Choi, Susie, Bhuvanagiri, Sai, Liu, Jinlu, Ravi Kumar, Sangeetha, Bohner, Austin, Carroll, Lara, Archer, Bonnie, Zhang, Yue, Liu, Wei, Gao, Guangping, Ambati, Jayakrishna, Jun, Albert S, Ambati, Balamurali K

“…A missense mutation of collagen type VIII alpha 2 chain ( ) gene leads to early-onset Fuchs' endothelial corneal dystrophy (FECD), which progressively impairs…”
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Age-Related Macular Degeneration: Etiology, Pathogenesis, and Therapeutic Strategies by Ambati, Jayakrishna, Ambati, Balamurali K, Yoo, Sonia H, Ianchulev, Sean, Adamis, Anthony P

“…Age-related macular degeneration is the principal cause of registered legal blindness among those aged over 65 in the United States, western Europe, Australia,…”
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Intravitreal AAV2.COMP-Ang1 Prevents Neurovascular Degeneration in a Murine Model of Diabetic Retinopathy by Cahoon, Judd M, Rai, Ruju R, Carroll, Lara S, Uehara, Hironori, Zhang, Xiaohui, O'Neil, Christina L, Medina, Reinhold J, Das, Subtrata K, Muddana, Santosh K, Olson, Paul R, Nielson, Spencer, Walker, Kortnie, Flood, Maggie M, Messenger, Wyatt B, Archer, Bonnie J, Barabas, Peter, Krizaj, David, Gibson, Christopher C, Li, Dean Y, Koh, Gou Y, Gao, Guangping, Stitt, Alan W, Ambati, Balamurali K

“…Diabetic retinopathy (DR) is the leading cause of blindness in the working-age population in the U.S. The vision-threatening processes of neuroglial and…”
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Intracorneal ring segments followed by toric pseudoaccomodating IOL for treatment of patients with corneal ectasia and cataract by Konda, Sneha, Ambati, Balamurali K.

“…Surgical management of keratoconus aims to improve corneal curvature, prevent progression of corneal ectasia, and manage refractive error. In older individuals…”
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ERK1/2 activation is a therapeutic target in age-related macular degeneration by Dridi, Sami, Hirano, Yoshio, Tarallo, Valeria, Kim, Younghee, Fowler, Benjamin J, Ambati, Balamurali K, Bogdanovich, Sasha, Chiodo, Vince A, Hauswirth, William W, Kugel, Jennifer F, Goodrich, James A, Ponicsan, Steven L, Hinton, David R, Kleinman, Mark E, Baffi, Judit Z, Gelfand, Bradley D, Ambati, Jayakrishna

“…Deficient expression of the RNase III DICER1, which leads to the accumulation of cytotoxic Alu RNA, has been implicated in degeneration of the retinal…”
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Targeted Intraceptor Nanoparticle Therapy Reduces Angiogenesis and Fibrosis in Primate and Murine Macular Degeneration by Luo, Ling, Zhang, Xiaohui, Hirano, Yoshio, Tyagi, Puneet, Barabás, Péter, Uehara, Hironori, Miya, Tadashi R, Singh, Nirbhai, Archer, Bonnie, Qazi, Yureeda, Jackman, Kyle, Das, Subrata K, Olsen, Thomas, Chennamaneni, Srinivas R, Stagg, Brian C, Ahmed, Faisal, Emerson, Lyska, Zygmunt, Kristen, Whitaker, Ross, Mamalis, Christina, Huang, Wei, Gao, Guangping, Srinivas, Sangly P, Krizaj, David, Baffi, Judit, Ambati, Jayakrishna, Kompella, Uday B, Ambati, Balamurali K

“…Monthly intraocular injections are widely used to deliver protein-based drugs that cannot cross the blood-retina barrier for the treatment of leading blinding…”
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An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice by Ambati, Jayakrishna, Anand, Akshay, Fernandez, Stefan, Sakurai, Eiji, Lynn, Bert C, Kuziel, William A, Rollins, Barrett J, Ambati, Balamurali K

“…The study and treatment of age-related macular degeneration (AMD), a leading cause of blindness, has been hampered by a lack of animal models. Here we report…”
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Short-interfering RNAs Induce Retinal Degeneration via TLR3 and IRF3 by Kleinman, Mark E, Kaneko, Hiroki, Cho, Won Gil, Dridi, Sami, Fowler, Benjamin J, Blandford, Alexander D, Albuquerque, Romulo JC, Hirano, Yoshio, Terasaki, Hiroko, Kondo, Mineo, Fujita, Takashi, Ambati, Balamurali K, Tarallo, Valeria, Gelfand, Bradley D, Bogdanovich, Sasha, Baffi, Judit Z, Ambati, Jayakrishna

“…The discovery of sequence-specific gene silencing by endogenous double-stranded RNAs (dsRNA) has propelled synthetic short-interfering RNAs (siRNAs) to the…”
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Small Interfering RNA-Induced TLR3 Activation Inhibits Blood and Lymphatic Vessel Growth by Cho, Won Gil, Albuquerque, Romulo J. C., Kleinman, Mark E., Tarallo, Valeria, Greco, Adelaide, Nozaki, Miho, Green, Martha G., Baffi, Judit Z., Ambati, Balamurali K., De Falco, Massimo, Alexander, Jonathan S., Brunetti, Arturo, De Falco, Sandro, Ambati, Jayakrishna, Ferrara, Napoleone

“…Neovascularization in response to tissue injury consists of the dual invasion of blood (hemangiogenesis) and lymphatic (lymphangiogenesis) vessels. We reported…”
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Nanoparticle-mediated delivery of shRNA.VEGF-a plasmids regresses corneal neovascularization by Qazi, Yureeda, Stagg, Brian, Singh, Nirbhai, Singh, Swita, Zhang, Xiaohui, Luo, Ling, Simonis, Jacquelyn, Kompella, Uday B, Ambati, Balamurali K

“…To determine the efficacy of a plasmid containing a small hairpin RNA expression cassette (pSEC.shRNA) against VEGF-A-loaded poly(lactic co-glycolic acid)…”
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