Search Results - "Amatruda, T."

Randomized phase II trial of autologous dendritic cell vaccines versus autologous tumor cell vaccines in metastatic melanoma: 5-year follow up and additional analyses by Dillman, Robert O, Cornforth, Andrew N, Nistor, Gabriel I, McClay, Edward F, Amatruda, Thomas T, Depriest, Carol

“…Despite improved survival following checkpoint inhibitors, there is still a potential role for anti-cancer therapeutic vaccines. Because of biological…”
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A Randomized Phase 2 Study of Temozolomide and Bevacizumab or nab-Paclitaxel, Carboplatin, and Bevacizumab in Patients With Unresectable Stage IV Melanoma: A North Central Cancer Treatment Group Study, N0775 by KOTTSCHADE, Lisa A, SUMAN, Vera J, KOSEL, Matthew L, MARKOVIC, Svetomir N, PEREZ, Domingo G, MCWILLIAMS, Robert R, KAUR, Judith S, AMATRUDA, Thomas T, GEOFFROY, Francois J, GROSS, Howard M, COHEN, Peter A, JASLOWSKI, Anthony J

“…Increasing evidence shows chemotherapy in combination with vascular endothelial growth factor (VEGF) inhibition is a clinically active therapy for patients…”
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Serial Monitoring of Circulating Melanoma Cells During Neoadjuvant Biochemotherapy for Stage III Melanoma: Outcome Prediction in a Multicenter Trial by KOYANAGT, Kazuo, O'DAY, Steven J, HOON, Dave S. B, GONZALEZ, Rene, LEWIS, Karl, ROBINSON, William A, AMATRUDA, Thomas T, WANG, He-Jing, ELASHOFF, Robert M, TAKENCHI, Hiroya, UMETANI, Naoynki

“…Circulating tumor cells (CTCs) in blood may be important in assessing tumor progression and treatment response. We hypothesized that quantitative real-time…”
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The Effect of Gene Mutations on Survival in Patients With Melanoma Following the Development of Brain Metastases by Sperduto, P.W, Jiang, W, Brown, P.D, Braunstein, S.E, Sneed, P.K, Wattson, D.A, Shih, H.A, Bangdiwala, A, Shanley, R, Lockney, N.A, Beal, K, Lou, E, Amatruda, T, Sperduto, W.A, Kirkpatrick, J.P, Yeh, N, Gaspar, L.E, Molitoris, J.K, Masucci, L, Roberge, D, Yu, J.B, Chiang, V.L, Mehta, M.P

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3334 Durable complete responses (CR) in patients (pts) with stage IIIB-IV melanoma treated with talimogene laherparepvec (T-VEC) in OPTiM by Andtbacka, R.H.I, Kaufman, H, Collichio, F, Amatruda, T, Nemunaitis, J, Chesney, J, Puzanov, I, Harrington, K, Zhang, Y, Chen, L, Shilkrut, M, Ross, M

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G alpha 16, a G protein alpha subunit specifically expressed in hematopoietic cells by T T Amatruda, 3rd, D A Steele, V Z Slepak, M I Simon

“…Signal-transduction pathways mediated by guanine nucleotide-binding regulatory proteins (G proteins) determine many of the responses of hematopoietic cells. A…”
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Specific interactions of chemoattractant factor receptors with G-proteins by Amatruda, T.T., Gerard, N.P., Gerard, C., Simon, M.I.

“…Stimulation of leukocytes with chemoattractant ligands activates phospholipid turnover and calcium release, ultimately leading to chemotaxis, degranulation,…”
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Microphthalmia transcription factor as a molecular marker for circulating tumor cell detection in blood of melanoma patients by KOYANAGI, Kazuo, O'DAY, Steven J, HOON, Dave S. B, GONZALEZ, Rene, LEWIS, Karl, ROBINSON, William A, AMATRUDA, Thomas T, KUO, Christine, WANG, He-Jing, MILFORD, Robert, MORTON, Donald L

“…PURPOSE: Microphthalmia transcription factor (Mitf), which is important in melanocyte development and melanoma growth, was assessed using real-time…”
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Phase II Multicenter Study of Neoadjuvant Biochemotherapy for Patients With Stage III Malignant Melanoma by LEWIS, Karl D, ROBINSON, William A, DOLLARHIDE, Susan, MATIJEVICH, Karen, GONZALEZ, Rene, MCCARTER, Martin, PEARLMAN, Nathan, O'DAY, Steven, ANDERSON, Clay, AMATRUDA, Thomas T, BARON, Anna, CHAN ZENG, BECKER, Maude

“…To determine the relapse-free survival, overall survival, and response rate of patients with stage III melanoma treated with neoadjuvant biochemotherapy in a…”
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Distinct Forms of the β Subunit of GTP-Binding Regulatory Proteins Identified by Molecular Cloning by FONG, H. K. W, AMATRUDA, T. T. III, BIRREN, B. W, SIMON, M. I

“…Two distinct β subunits of guanine nucleotide-binding regulatory proteins have been identified by cDNA cloning and are referred to as β1and β2subunits. The…”
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Effect of risk-reducing salpingo-oophorectomy on sex steroid hormone serum levels among postmenopausal women: an NRG Oncology/Gynecologic Oncology Group study by Mai, Phuong L., Miller, Austin, Black, Amanda, Falk, Roni T., Boggess, John F., Tucker, Katherine, Stuckey, Ashley R., Rodriguez, Gustavo C., Wong, Cheung, Amatruda, Thomas T., Wilkinson, Kelly J., Modesitt, Susan C., Yamada, S. Diane, Bixel, Kristin L., Glaser, Gretchen E., Rose, Peter G., Greene, Mark H., Sherman, Mark E.

“…Risk-reducing salpingo-oophorectomy is an effective ovarian cancer risk reduction strategy. However, bilateral oophorectomy has also been associated with…”
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Patient-reported tolerability of adjuvant ipilimumab (3 or 10 mg/kg) versus high-dose interferon alfa-2b for resected high-risk stage III–IV melanoma in phase III trial E1609 by McLouth, Laurie E., Zheng, Yue, Smith, Stephanie, Hodi, F. Stephen, Rao, Uma N., Cohen, Gary I., Amatruda, Thomas T., Dakhil, Shaker R., Curti, Brendan D., Nakhoul, Ibrahim, Chandana, Sreenivasa R., Bane, Charles L., Marinier, David E., Lee, Sandra J., Sondak, Vernon K., Kirkwood, John M., Tarhini, Ahmad A., Wagner, Lynne I.

“…Purpose Trial E1609 demonstrated superior overall survival with ipilimumab 3 mg/kg (ipi3) compared to high-dose interferon (HDI) for patients with resected…”
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Evolution of the mammalian G protein α subunit multigene family by Wilkie, Thomas M, Gilbert, Debra J, Olsen, Anne S, Chen, Xiao-Ning, Amatruda, Thomas T, Korenberg, Julie R, Trask, Barbara J, de Jong, Pieter, Reed, Randall R, Simon, Melvin I, Jenkins, Nancy A, Copeland, Neal G

“…Heterotrimeric guanine nucleotide binding proteins (G proteins) transduce extracellular signals received by transmembrane receptors to effector proteins. The…”
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Tumor Stem Cell Antigens as Consolidative Active Specific Immunotherapy: A Randomized Phase II Trial of Dendritic Cells Versus Tumor Cells in Patients With Metastatic Melanoma by DILLMAN, Robert O, CORNFORTH, Andrew N, DEPRIEST, Carol, MCCLAY, Edward F, AMATRUDA, Thomas T, DE LEON, Cristina, ELLIS, Robin E, MAYORGA, Cheryl, CARBONELL, Denysha, CUBELLIS, James M

“…Only 10% of metastatic melanoma patients survive 5 years, even though many can achieve substantial tumor reduction by surgical resection and/or radiation…”
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Prognostic significance of microscopic tumor burden in sentinel lymph node in patients with cutaneous melanoma by Kim, Chul, Economou, Sam, Amatruda, Thomas T, Martin, Jena C, Dudek, Arkadiusz Z

“…Sentinel lymph node (SLN) biopsy provides useful prognostic information for patients with melanoma. The present study sought to determine the prognostic value…”
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Signal transduction by the formyl peptide receptor. Studies using chimeric receptors and site-directed mutagenesis define a novel domain for interaction with G-proteins by Amatruda, 3rd, T T, Dragas-Graonic, S, Holmes, R, Perez, H D

“…The binding of small peptide ligands to high affinity chemoattractant receptors on the surface of neutrophils and monocytes leads to activation of…”
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Serial monitoring of circulating tumor cells predicts outcome of induction biochemotherapy plus maintenance biotherapy for metastatic melanoma by Koyanagi, Kazuo, O'Day, Steven J, Boasberg, Peter, Atkins, Michael B, Wang, He-Jing, Gonzalez, Rene, Lewis, Karl, Thompson, John A, Anderson, Clay M, Lutzky, Jose, Amatruda, Thomas T, Hersh, Evan, Richards, Jon, Weber, Jeffrey S, Hoon, Dave S B

“…Molecular biomarkers in blood are promising for assessment of tumor progression and treatment response. We hypothesized that serial monitoring of circulating…”
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Dendritic Versus Tumor Cell Presentation of Autologous Tumor Antigens for Active Specific Immunotherapy in Metastatic Melanoma: Impact on Long-Term Survival by Extent of Disease at the Time of Treatment by Dillman, Robert O, McClay, Edward F, Barth, Neil M, Amatruda, Thomas T, Schwartzberg, Lee S, Mahdavi, Khosrow, de Leon, Cristina, Ellis, Robin E, DePriest, Carol

“…In patients with metastatic melanoma, sequential single-arm and randomized phase II trials with a therapeutic vaccine consisting of autologous dendritic cells…”
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Gα16, a G Protein α Subunit Specifically Expressed in Hematopoietic Cells by Amatruda, Thomas T., Steele, David A., Slepak, Vladlen Z., Simon, Melvin I.

“…Signal-transduction pathways mediated by guanine nucleotide-binding regulatory proteins (G proteins) determine many of the responses of hematopoietic cells. A…”
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The 35- and 36-kDa beta subunits of GTP-binding regulatory proteins are products of separate genes by Amatruda, T T, Gautam, N, Fong, H K, Northup, J K, Simon, M I

“…The wide range of functions attributed to GTP-binding regulatory proteins (G proteins) is reflected in the structural diversity which exists among the alpha,…”
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