Search Results - "Amatngalim, Gimano D."

High-resolution 3D imaging of fixed and cleared organoids by Dekkers, Johanna F., Alieva, Maria, Wellens, Lianne M., Ariese, Hendrikus C. R., Jamieson, Paul R., Vonk, Annelotte M., Amatngalim, Gimano D., Hu, Huili, Oost, Koen C., Snippert, Hugo J. G., Beekman, Jeffrey M., Wehrens, Ellen J., Visvader, Jane E., Clevers, Hans, Rios, Anne C.

“…In vitro 3D organoid systems have revolutionized the modeling of organ development and diseases in a dish. Fluorescence microscopy has contributed to the…”
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CRISPR-Based Adenine Editors Correct Nonsense Mutations in a Cystic Fibrosis Organoid Biobank by Geurts, Maarten H., de Poel, Eyleen, Amatngalim, Gimano D., Oka, Rurika, Meijers, Fleur M., Kruisselbrink, Evelien, van Mourik, Peter, Berkers, Gitte, de Winter-de Groot, Karin M., Michel, Sabine, Muilwijk, Danya, Aalbers, Bente L., Mullenders, Jasper, Boj, Sylvia F., Suen, Sylvia W.F., Brunsveld, Jesse E., Janssens, Hettie M., Mall, Marcus A., Graeber, Simon Y., van Boxtel, Ruben, van der Ent, Cornelis K., Beekman, Jeffrey M., Clevers, Hans

“…Adenine base editing (ABE) enables enzymatic conversion from A-T into G-C base pairs. ABE holds promise for clinical application, as it does not depend on the…”
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Basal cells contribute to innate immunity of the airway epithelium through production of the antimicrobial protein RNase 7 by Amatngalim, Gimano D, van Wijck, Yolanda, de Mooij-Eijk, Yvonne, Verhoosel, Renate M, Harder, Jürgen, Lekkerkerker, Annemarie N, Janssen, Richard A J, Hiemstra, Pieter S

“…Basal cells play a critical role in the response of the airway epithelium to injury and are recently recognized to also contribute to epithelial immunity…”
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Exploring intrinsic variability between cultured nasal and bronchial epithelia in cystic fibrosis by Rodenburg, Lisa W., Metzemaekers, Mieke, van der Windt, Isabelle S., Smits, Shannon M. A., den Hertog-Oosterhoff, Loes A., Kruisselbrink, Evelien, Brunsveld, Jesse E., Michel, Sabine, de Winter-de Groot, Karin M., van der Ent, Cornelis K., Stadhouders, Ralph, Beekman, Jeffrey M., Amatngalim, Gimano D.

“…The nasal and bronchial epithelium are unified parts of the respiratory tract that are affected in the monogenic disorder cystic fibrosis (CF). Recent studies…”
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Cigarette Smoke Modulates Repair and Innate Immunity following Injury to Airway Epithelial Cells by Amatngalim, Gimano D, Broekman, Winifred, Daniel, Nadia M, van der Vlugt, Luciën E P M, van Schadewijk, Annemarie, Taube, Christian, Hiemstra, Pieter S

“…Cigarette smoking is the main risk factor associated with chronic obstructive pulmonary disease (COPD), and contributes to COPD development and progression by…”
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Drug Repurposing for Cystic Fibrosis: Identification of Drugs That Induce CFTR-Independent Fluid Secretion in Nasal Organoids by Rodenburg, Lisa W, Delpiano, Livia, Railean, Violeta, Centeio, Raquel, Pinto, Madalena C, Smits, Shannon M A, van der Windt, Isabelle S, van Hugten, Casper F J, van Beuningen, Sam F B, Rodenburg, Remco N P, van der Ent, Cornelis K, Amaral, Margarida D, Kunzelmann, Karl, Gray, Michael A, Beekman, Jeffrey M, Amatngalim, Gimano D

“…Individuals with cystic fibrosis (CF) suffer from severe respiratory disease due to a genetic defect in the cystic fibrosis transmembrane conductance regulator…”
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Airway Epithelial Cell Function and Respiratory Host Defense in Chronic Obstructive Pulmonary Disease by Amatngalim, Gimano, Hiemstra, Pieter

“…The airway epithelium has a range of properties that contribute to lung defense, including constitutive host defense mechanisms and regulation of airway innate…”
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Protocol for generating airway organoids from 2D air liquid interface-differentiated nasal epithelia for use in a functional CFTR assay by Rodenburg, Lisa W., van der Windt, Isabelle S., Dreyer, Henriette H.M., Smits, Shannon M.A., den Hertog - Oosterhoff, Loes A., Aarts, Ellen M., Beekman, Jeffrey M., Amatngalim, Gimano D.

“…We present a protocol to generate organoids from air-liquid-interface (ALI)-differentiated nasal epithelia. We detail their application as cystic fibrosis (CF)…”
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Airway Epithelial Cultures of Children with Esophageal Atresia as a Model to Study Respiratory Tract Disorders by Dreyer, Henriette H M, van Tuyll van Serooskerken, Eleonora Sofie, Rodenburg, Lisa W, Bittermann, Arnold J N, Arets, Hubertus G M, Reuling, Ellen M B P, Verweij, Johannes W, Haarman, Eric G, van der Zee, David C, Tytgat, Stefaan H A J, van der Ent, Cornelis K, Beekman, Jeffrey M, Amatngalim, Gimano D, Lindeboom, Maud Y A

“…Esophageal atresia (EA) is a rare birth defect in which respiratory tract disorders are a major cause of morbidity. It remains unclear whether respiratory…”
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Contribution of Host Defence Proteins and Peptides to Host-Microbiota Interactions in Chronic Inflammatory Lung Diseases by van der Does, Anne M, Amatngalim, Gimano D, Keijser, Bart, Hiemstra, Pieter S, Villenave, Remi

“…The respiratory tract harbours a variety of microorganisms, collectively called the respiratory microbiota. Over the past few years, alterations in respiratory…”
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Long‐term expanding human airway organoids for disease modeling by Sachs, Norman, Papaspyropoulos, Angelos, Zomer‐van Ommen, Domenique D, Heo, Inha, Böttinger, Lena, Klay, Dymph, Weeber, Fleur, Huelsz‐Prince, Guizela, Iakobachvili, Nino, Amatngalim, Gimano D, de Ligt, Joep, van Hoeck, Arne, Proost, Natalie, Viveen, Marco C, Lyubimova, Anna, Teeven, Luc, Derakhshan, Sepideh, Korving, Jeroen, Begthel, Harry, Dekkers, Johanna F, Kumawat, Kuldeep, Ramos, Emilio, van Oosterhout, Matthijs FM, Offerhaus, G Johan, Wiener, Dominique J, Olimpio, Eduardo P, Dijkstra, Krijn K, Smit, Egbert F, van der Linden, Maarten, Jaksani, Sridevi, van de Ven, Marieke, Jonkers, Jos, Rios, Anne C, Voest, Emile E, van Moorsel, Coline HM, van der Ent, Cornelis K, Cuppen, Edwin, van Oudenaarden, Alexander, Coenjaerts, Frank E, Meyaard, Linde, Bont, Louis J, Peters, Peter J, Tans, Sander J, van Zon, Jeroen S, Boj, Sylvia F, Vries, Robert G, Beekman, Jeffrey M, Clevers, Hans

“…Organoids are self‐organizing 3D structures grown from stem cells that recapitulate essential aspects of organ structure and function. Here, we describe a…”
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Antimicrobial Peptides and Innate Lung Defenses: Role in Infectious and Noninfectious Lung Diseases and Therapeutic Applications by Hiemstra, Pieter S, Amatngalim, Gimano D, van der Does, Anne M, Taube, Christian

“…Respiratory infections are a major clinical problem, and treatment is increasingly complicated by the emergence of microbial antibiotic resistance. Development…”
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TNF-α and IL-1β-activated human mesenchymal stromal cells increase airway epithelial wound healing in vitro via activation of the epidermal growth factor receptor by Broekman, Winifred, Amatngalim, Gimano D, de Mooij-Eijk, Yvonne, Oostendorp, Jaap, Roelofs, Helene, Taube, Christian, Stolk, Jan, Hiemstra, Pieter S

“…Mesenchymal stromal cells (MSCs) are investigated for their potential to reduce inflammation and to repair damaged tissue. Inflammation and tissue damage are…”
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Dynamic regulation of airway surface liquid pH by TMEM16A and SLC26A4 in cystic fibrosis nasal epithelia with rare mutations by Delpiano, Livia, Rodenburg, Lisa W., Burke, Matthew, Nelson, Glyn, Amatngalim, Gimano D., Beekman, Jeffrey M., Gray, Michael A.

“…In cystic fibrosis (CF), defects in the CF transmembrane conductance regulator (CFTR) channel lead to an acidic airway surface liquid (ASL), which compromises…”
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Polymeric immunoglobulin receptor down-regulation in chronic obstructive pulmonary disease. Persistence in the cultured epithelium and role of transforming growth factor-β by Gohy, Sophie T, Detry, Bruno R, Lecocq, Marylène, Bouzin, Caroline, Weynand, Birgit A, Amatngalim, Gimano D, Sibille, Yves M, Pilette, Charles

“…The generation of protective secretory IgA relies on the epithelial polymeric immunoglobulin receptor (pIgR). pIgR expression is reduced in chronic obstructive…”
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Getting neural about airway gland secretion by Amatngalim, Gimano D, Ribeiro, Carla M P

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Aberrant epithelial differentiation by cigarette smoke dysregulates respiratory host defence by Amatngalim, Gimano D, Schrumpf, Jasmijn A, Dishchekenian, Fernanda, Mertens, Tinne C J, Ninaber, Dennis K, van der Linden, Abraham C, Pilette, Charles, Taube, Christian, Hiemstra, Pieter S, van der Does, Anne M

“…It is currently unknown how cigarette smoke-induced airway remodelling affects highly expressed respiratory epithelial defence proteins and thereby mucosal…”
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Proinflammatory Cytokines Impair Vitamin D-Induced Host Defense in Cultured Airway Epithelial Cells by Schrumpf, Jasmijn A, Amatngalim, Gimano D, Veldkamp, Joris B, Verhoosel, Renate M, Ninaber, Dennis K, Ordonez, Soledad R, van der Does, Anne M, Haagsman, Henk P, Hiemstra, Pieter S

“…Vitamin D is a regulator of host defense against infections and induces expression of the antimicrobial peptide hCAP18/LL-37. Vitamin D deficiency is…”
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Recurrent Respiratory Syncytial Virus Infection in a CD14-Deficient Patient by Besteman, Sjanna B, Phung, Emily, Raeven, Henriette H M, Amatngalim, Gimano D, Rumpret, Matevž, Crabtree, Juliet, Schepp, Rutger M, Rodenburg, Lisa W, Siemonsma, Susanna G, Verleur, Nile, van Slooten, Rianne, Duran, Karen, van Haaften, Gijs W, Beekman, Jeffrey M, Chang, Lauren A, Meyaard, Linde, van der Bruggen, Tjomme, Berbers, Guy A M, Derksen, Nicole, Nierkens, Stefan, Morabito, Kaitlyn M, Ruckwardt, Tracy J, Kurt-Jones, Evelyn A, Golenbock, Douglas, Graham, Barney S, Bont, Louis J

“…Abstract Background Recurrent respiratory syncytial virus (RSV) infection requiring hospitalization is rare and the underlying mechanism is unknown. We aimed…”
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Antibacterial Defense of Human Airway Epithelial Cells from Chronic Obstructive Pulmonary Disease Patients Induced by Acute Exposure to Nontypeable Haemophilus influenzae: Modulation by Cigarette Smoke by Amatngalim, Gimano D., Schrumpf, Jasmijn A., Henic, Almira, Dronkers, Esther, Verhoosel, Renate M., Ordonez, Soledad R., Haagsman, Henk P., Fuentes, Maria E., Sridhar, Sriram, Aarbiou, Jamil, Janssen, Richard A.J., Lekkerkerker, Annemarie N., Hiemstra, Pieter S.

“…Antimicrobial proteins and peptides (AMPs) are a central component of the antibacterial activity of airway epithelial cells. It has been proposed that a…”
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