Antiulcerogenic Activity of the Hydroalcoholic Extract of Leaves of Croton campestris A. St.-Hill in Rodents

Croton campestris A. St.-Hill., popularly known as “velame do campo,” is a species native to the savannah area of Northeast Brazil, which is used by traditional communities in folk medicine for variety of health problems, especially detoxification, inflammation, and gastritis. The hydroalcoholic ext...

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Bibliographic Details
Published in:	Evidence-based complementary and alternative medicine Vol. 2013; no. 2013; pp. 1 - 10
Main Authors:	Sampaio, Renata S., Siebra, Ana Luiza A., Souza, Daniele O., Leite, Laura H. I., Bento, Elizângela B., de Oliveira, Dayanne R., Júnior, Francisco E. B., Martins, Anita O. P. B., Ramos, Andreza G. B., Tintino, Saulo R., Lacerda-Neto, Luiz J., Figueiredo, Patricia R. L., Oliveira, Larissa R., Rodrigues, Cristina K. S., Sales, Valterlúcio S., Figueiredo, Francisco R. S. D. N., Nascimento, Emmily P., Monteiro, Alefe B., Amaro, Érika N., Costa, José Galberto Martins da, Douglas Melo Coutinho, Henrique, de Menezes, Irwin Rose Alencar, Kerntopf, Marta Regina
Format:	Journal Article
Language:	English
Published:	Cairo, Egypt Hindawi Puplishing Corporation 01-01-2013 Hindawi Publishing Corporation Hindawi Limited
Subjects:	Animal models Detoxification Drugs Ethanol Flavonoids Gastritis Gastroenterology Health problems Indigenous species Intestinal motility Intestine Leaves Mice Motility Nitric oxide Pathogenesis Phytochemicals Rodents Savannahs Smooth muscle Tropical diseases Ulcers Brazil
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Summary:	Croton campestris A. St.-Hill., popularly known as “velame do campo,” is a species native to the savannah area of Northeast Brazil, which is used by traditional communities in folk medicine for variety of health problems, especially detoxification, inflammation, and gastritis. The hydroalcoholic extract of C. campestris leaves (HELCC) was assessed for its antiulcerogenic effect in gastric lesion models and effect on intestinal motility in mice, and possible mechanisms of action were examined. HELCC showed significant gastroprotective action in all models of gastric ulcer evaluated; the results suggest that this action probably involves the nitric oxide pathway. HELCC did not show alteration of intestinal motility in mice. It was also found that C. campestris represents a promising natural source with important biological potential, justifying some of its uses in folk medicine.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Academic Editor: Ulysses Paulino de Albuquerque
ISSN:	1741-427X 1741-4288
DOI:	10.1155/2013/579346