Search Results - "Amarasinghe, Kande K.D."

One-pot synthesis of 1,2,4-oxadiazoles from carboxylic acid esters and amidoximes using potassium carbonate by Amarasinghe, Kande K.D., Maier, Matthew B., Srivastava, Anil, Gray, Jeffrey L.

“…A convenient one-pot synthesis of 1,2,4-oxadiazoles is described. The condensation of carboxylic acid esters and amidoximes in the presence of potassium…”
Get full text

Asymmetric Synthesis of Tetrabenazine and Dihydrotetrabenazine by Rishel, Michael J, Amarasinghe, Kande K. D, Dinn, Sean R, Johnson, Bruce F

“…The enantioselective synthesis of (+)-tetrabenazine (TBZ) and (+)-dihydrotetrabenazine (DTBZ), agents of significant interest for therapeutic and molecular…”
Get full text

Combined Experimental and Computational Investigation of the Mechanism of Nickel-Catalyzed Three-Component Addition Processes by Hratchian, Hrant P, Chowdhury, Sanjoy K, Gutiérrez-García, Víctor M, Amarasinghe, Kande K. D, Heeg, Mary Jane, Schlegel, H. Bernhard, Montgomery, John

“…The mechanism of nickel-catalyzed couplings of an enone, alkyne, and organozinc has been studied. Adducts of the substrates with nickel(0) have been isolated…”
Get full text

Nickel-Catalyzed Cyclizations and Couplings with Vinylzirconium Reagents by Ni, Yike, Amarasinghe, Kande K. D, Montgomery, John

“…1,3-Dienes were prepared by a variety of nickel-catalyzed couplings and cyclization processes. Intermolecular or partially intramolecular couplings of alkynes,…”
Get full text

First Total Synthesis and Stereochemical Definition of Isodomoic Acid G by Ni, Yike, Amarasinghe, Kande K. D, Ksebati, Bashar, Montgomery, John

“…The first total synthesis and stereochemical definition of isodomoic acid G has been achieved. The key nickel-catalyzed coupling of an alkynyl enone with an…”
Get full text

Cascade Cyclizations and Couplings Involving Nickel Enolates by Mahandru, Gireesh M, Skauge, Andy R. L, Chowdhury, Sanjoy K, Amarasinghe, Kande K. D, Heeg, Mary Jane, Montgomery, John

“…A new strategy for effecting cascade cyclization processes using nickel enolates has been developed. Nickel enolates may be cleanly generated by the oxidative…”
Get full text

Design and synthesis of potent, non-peptidic inhibitors of HPTPβ by Amarasinghe, Kande K.D., Evidokimov, Artem G., Xu, Kevin, Clark, Cynthia M., Maier, Matthew B., Srivastava, Anil, Colson, Anny-Odile, Gerwe, Gina S., Stake, George E., Howard, Brian W., Pokross, Matthew E., Gray, Jeffrey L., Peters, Kevin G.

“…The sulfamic acid phosphotyrosine mimetic was coupled with a previously known malonate template to obtain highly selective and potent inhibitors of HPTPβ…”
Get full text

Enantioselective Total Synthesis of (+)-Testudinariol A Using a New Nickel-Catalyzed Allenyl Aldehyde Cyclization by Amarasinghe, Kande K. D, Montgomery, John

“…An enantioselective total synthesis of (+)-testudinariol A was completed. A new nickel-catalyzed allenyl aldehyde cyclization was developed in the approach. In…”
Get full text

Corrigendum to “Design and synthesis of potent, non-peptidic inhibitors of HPTPβ” [Bioorg. Med. Chem. Lett. 16 (2006) 4252–4256] by Amarasinghe, Kande K.D., Evdokimov, Artem G., Xu, Kevin, Clark, Cynthia M., Maier, Matthew B., Srivastava, Anil, Colson, Anny-Odile, Gerwe, Gina S., Stake, George E., Howard, Brian W., Pokross, Matthew E., Gray, Jeffrey L., Peters, Kevin G.

Get full text

Nickel-catalyzed cyclizations of alkynyl enones and alkynyl enals by Montgomery, John, Amarasinghe, Kande K. D., Chowdhury, Sanjoy K., Oblinger, Eric, Seo, Jeongbeob, Savchenko, Alexey V.

“…Substrates that possess an a,b-unsaturated carbonyl tethered to an alkyne have been utilized in a variety of nickel-catalyzed processes. Depending on ligand…”
Get full text