Search Results - "Amarante, Giovanni W"

Azlactone Reaction Developments by de Castro, Pedro P., Carpanez, Arthur G., Amarante, Giovanni W.

“…Azlactones (also known as oxazolones) are heterocycles usually employed in the stereoselective synthesis of α,α‐amino acids, heterocycles and natural products…”
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Recent Advances in Azlactone Transformations by Marra, Isabella F. S., de Castro, Pedro P., Amarante, Giovanni W.

“…Azlactones, also known as oxazolones, are versatile building blocks in organic synthesis due to the presence of multiple pro‐nucleophilic and electrophilic…”
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Gold(I)-Catalyzed Diastereo- and Enantioselective 1,3-Dipolar Cycloaddition and Mannich Reactions of Azlactones by Melhado, Asa D, Amarante, Giovanni W, Wang, Z. Jane, Luparia, Marco, Toste, F. Dean

“…Azlactones participate in stereoselective reactions with electron-deficient alkenes and N-sulfonyl aldimines to give products of 1,3-dipolar cycloaddition and…”
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Recent Advances in Asymmetric Counteranion-directed Catalysis (ACDC) by Ávila, Eloah P., Amarante, Giovanni W.

“…As expected, chemists have dedicated efforts in the development of asymmetric catalytic reactions based on lessons from nature. The decisive presence of the…”
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Brønsted Acid Catalyzed Morita-Baylis-Hillman Reaction: A New Mechanistic View for Thioureas Revealed by ESI-MS(/MS) Monitoring and DFT Calculations by Amarante, Giovanni W., Benassi, Mario, Milagre, Humberto M. S., Braga, Ataualpa A. C., Maseras, Feliu, Eberlin, Marcos N., Coelho, Fernando

“…A Morita–Baylis–Hillman (MBH) reaction catalyzed by thiourea was monitored by ESI‐MS(/MS) and key intermediates were intercepted and characterized. These…”
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Dualistic Nature of the Mechanism of the Morita−Baylis−Hillman Reaction Probed by Electrospray Ionization Mass Spectrometry by Amarante, Giovanni W, Milagre, Humberto M. S, Vaz, Boniek G, Vilachã Ferreira, Bruno R, Eberlin, Marcos N, Coelho, Fernando

“…The Morita−Baylis−Hillman (MBH) reaction allows chemists to form new σ C−C bonds in a single-step straightforward manner and thus to construct densely…”
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Tandem cycloisomerization/Suzuki coupling of arylethynyl MIDA boronates by Chan, Julian M.W., Amarante, Giovanni W., Toste, F. Dean

“…A tandem gold-catalyzed cycloisomerization/Suzuki cross-coupling sequence involving arylethynyl- N-methyliminodiacetic acid boronates is described. Combining…”
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Theoretical Study on the Epimerization of Azlactone Rings: Keto–Enol Tautomerism or Base-Mediated Racemization? by de Castro, Pedro P, Batista, Gabriel M. F, dos Santos, Hélio F, Amarante, Giovanni W

“…Azlactones are versatile heterocycles employed in a diversity of transformations; the main drawback of these cycles consists in the epimerization of the…”
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A Brønsted base-promoted diastereoselective dimerization of azlactones by Pinheiro, Danielle L J, Batista, Gabriel M F, de Castro, Pedro P, Flores, Leonã S, Andrade, Gustavo F S, Amarante, Giovanni W

“…A novel Brønsted base system for the diastereoselective dimerization of azlactones using trichloroacetate salts and acetonitrile has been developed. Desired…”
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Brønsted Acid-Catalyzed Epimerization-Free Preparation of Dual-Protected Amino Acid Derivatives by de Castro, Pedro P, Rimulo, Isabela M. R, de Almeida, Angelina M, Diniz, Renata, Amarante, Giovanni W

“…An organocatalytic protocol, employing the commercially available EDC as coupling agent, has been developed for the preparation of dual-protected amino acid…”
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Enhancing Efficiency and Sustainability: Unleashing the Potential of Continuous Flow in Multicomponent Reactions by Carvalho, Marcelo H R, de Castro, Pedro P, de Oliveira, Kleber T, Amarante, Giovanni Wilson

“…The integration of multicomponent reactions (MCRs), which offer a rapid and efficient approach to synthesize complex molecular scaffolds, with continuous flow…”
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Combined Role of the Asymmetric Counteranion-Directed Catalysis (ACDC) and Ionic Liquid Effect for the Enantioselective Biginelli Multicomponent Reaction by Alvim, Haline G. O, Pinheiro, Danielle L. J, Carvalho-Silva, Valter H, Fioramonte, Mariana, Gozzo, Fabio C, da Silva, Wender A, Amarante, Giovanni W, Neto, Brenno A. D

“…This work describes new chiral task-specific ionic liquids bearing chiral anions as the catalysts for the enantioselective multicomponent Biginelli reaction…”
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Recent Developments and Synthetic Applications of Nucleophilic Zirconocene Complexes from Schwartz's Reagent by Pinheiro, Danielle L. J., de Castro, Pedro P., Amarante, Giovanni W.

“…Organozirconium chemistry has been widely employed in organic synthesis since its discovery in the last century. In this context, Schwartz's reagent stands out…”
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Mechanism and Origin of Enantioselectivity in Bifunctional Squaramide‐Catalyzed α‐Thiolation of Azlactones by Santos, Izabela A., Castro, Pedro P., Dos Santos, Hélio F., Amarante, Giovanni W.

“…The full mechanism of the asymmetric α‐thiolation of azlactones catalyzed by a cinchona alkaloid‐derived squaramide was carefully investigated through…”
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Electron-Donor–Acceptor Complex-Enabled Flow Methodology for the Hydrotrifluoromethylation of Unsaturated β‑Keto Esters by Batista, Gabriel M. F, de Castro, Pedro P, Dos Santos, Hélio F, de Oliveira, Kleber T, Amarante, Giovanni W

“…A novel electron-donor–acceptor (EDA) complex-enabled flow photochemical hydrotrifluoromethylation of unsaturated β-keto esters is described. The developed…”
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Solvent Dependent Competitive Mechanisms for the Ugi Multicomponent Reaction: A Joint Theoretical and Experimental Study in the α‑Acyl Aminocarboxamides vs α‑Amino Amidines Formation by Carvalho, Marcelo H. R., Ribeiro, João P. R. S., De Castro, Pedro P., Passos, Saulo T. A., Neto, Brenno A. D., Dos Santos, Hélio F., Amarante, Giovanni W.

“…A synthetic protocol for the preparation of α-acyl aminocarboxamides and α-amino amidines is proposed. The selectivity toward each of these two possible…”
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An Improved Protocol for the Morita‐Baylis‐Hillman Reaction Allows Unprecedented Broad Synthetic Scope by Camilo, Nilton S., Santos, Hugo, Zeoly, Lucas A., Fernandes, Fábio S., Rodrigues, Manoel T., Silva, Thiago S., Lima, Samia R., Serafim, José Cláudio, Oliveira, Aline S. B., Carpanez, Arthur G., Amarante, Giovanni W., Coelho, Fernando

“…The Morita‐Baylis‐Hillman (MBH) reaction has been stablished as an important C−C bond‐forming transformation between carbonyl‐containing compounds and…”
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Origin of Enantioselectivity in Chiral Phosphoric-Acid-Catalyzed Azlactone Dynamic Kinetic Resolution by De Castro, Pedro P, Batista, Gabriel M. F, Amarante, Giovanni W, Dos Santos, Hélio F

“…Theoretical calculations, associated with control experiments, were carried out to gain insights into the mechanism and origin of enantioselectivity in the…”
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Diverse 3‑Methylthio-4-Substituted Maleimides through a Novel Rearrangement Reaction: Synthesis and Selective Cell Imaging by Meirelles, Luan V, de Castro, Pedro P, Passos, Saulo T. A, Carvalho, Bernardo B. P. P, Franco, Chris H. J, Correa, José R, Neto, Brenno A. D, Amarante, Giovanni W

“…A transition metal-free protocol for the preparation of fluorescent and non-fluoresent 3-methylthio-4-arylmaleimides in a single step through a new…”
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Chiral Brønsted Acid-Catalyzed Stereoselective Mannich-Type Reaction of Azlactones with Aldimines by Ávila, Eloah P, Justo, Rodrigo M. S, Gonçalves, Vanessa P, Pereira, Adriane A, Diniz, Renata, Amarante, Giovanni W

“…A highly diastereo- and enantioselective Mannich-type reaction of azlactones with aldimines catalyzed by a chiral phosphoric acid is described. Only 3 mol %…”
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