Tissue healing changes on wounds in rats after treatment with Hancornia speciosa latex in cream-gel formulation

Tissue healing changes on wounds in rats after treatment with Hancornia speciosa latex in cream-gel formulation

Hancornia speciosa latex has shown pharmacological potential in wound healing processes due to its angiogenic, osteogenic, and anti-inflammatory activities. The aims of this study were to carry out a cream-gel formulation with 5, 10 and 25% of H. speciosa serum latex and to evaluate its potential to...

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Bibliographic Details
Published in:Acta Cirúrgica Brasileira Vol. 37; no. 10; p. e371001
Main Authors: D'Abadia, Patrícia Lima, Lemes, Susy Ricardo, Melo-Reis, Paulo Roberto de, Lino Júnior, Ruy de Souza, Gonçalves, Pablo José, Reis, Diego Dos Santos, Caixeta, Graziele Alícia Batista, Amaral, Vanessa Cristine Santana, Almeida, Luciane Madureira
Format: Journal Article
Language:English
Published: Brazil Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 01-01-2022
Subjects:
Animals
Apocynaceae
Collagen
Latex - pharmacology
Original
Plant Extracts - pharmacology
Rats
Skin
Wound Healing
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Summary:Hancornia speciosa latex has shown pharmacological potential in wound healing processes due to its angiogenic, osteogenic, and anti-inflammatory activities. The aims of this study were to carry out a cream-gel formulation with 5, 10 and 25% of H. speciosa serum latex and to evaluate its potential to stimulate the skin regeneration in rats' wounds. One hundred and twenty rats were divided into five groups: neutral control with saline (G1), cream-gel based on H. speciosa latex serum at 5% m/v (G2), cream-gel at 15% m/v (G3), cream-gel at 25% m/v (G4), and cream-gel (G5). The animals were euthanized at three, seven, 14 and 21 days after the injury induction, and some parameters were analyzed: wound contraction, necrosis, fibrin, polymorphonuclear and mononuclear infiltrates, fibroblast, angiogenesis, hemorrhage, and collagen. The therapeutic treatment with cream-gel at 15 and 25% is beneficial in the inflammatory phase of healing processes since it increased the angiogenesis and proliferation of mononuclear infiltrations in wounds. Regarding wound contraction, the treatment with cream-gel (5 and 15%) induced a higher rate of contraction in the proliferative phase. The 15% cream-gel formulation stimulated a greater production of collagen in the injured tissues. H. speciosa cream-gel is a low-cost herbal medicine which can aid in tissue repair.
Bibliography:Conflict of interest: Nothing to declare.
ISSN:0102-8650
1678-2674
DOI:10.1590/acb371001