Search Results - "Amaral, M."

Novel personalized therapies for cystic fibrosis: treating the basic defect in all patients by Amaral, M. D.

“…Cystic fibrosis (CF) is the most common genetic life‐shortening condition in Caucasians. Despite being a multi‐organ disease, CF is classically diagnosed by…”
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Functionalizing nanoparticles with cancer-targeting antibodies: A comparison of strategies by Marques, A.C., Costa, P.J., Velho, S., Amaral, M.H.

“…Standard cancer therapies sometimes fail to deliver chemotherapeutic drugs to tumor cells in a safe and effective manner. Nanotechnology takes the lead in…”
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The role of inflammation in the pathology of preeclampsia by Harmon, Ashlyn C, Cornelius, Denise C, Amaral, Lorena M, Faulkner, Jessica L, Cunningham, Jr, Mark W, Wallace, Kedra, LaMarca, Babbette

“…Preeclampsia (PE) affects 5-7% of all pregnancies in the United States and is the leading cause of maternal and prenatal morbidity. PE is associated with…”
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Protein conformational flexibility modulates kinetics and thermodynamics of drug binding by Amaral, M., Kokh, D. B., Bomke, J., Wegener, A., Buchstaller, H. P., Eggenweiler, H. M., Matias, P., Sirrenberg, C., Wade, R. C., Frech, M.

“…Structure-based drug design has often been restricted by the rather static picture of protein–ligand complexes presented by crystal structures, despite the…”
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Pathophysiology and Current Clinical Management of Preeclampsia by Amaral, Lorena M., Wallace, Kedra, Owens, Michelle, LaMarca, Babbette

“…Preeclampsia is characterized by blood pressure greater than 140/90 mmHg in the second half of pregnancy. This disease is a major contributor to preterm and…”
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Resource recovery from sugarcane vinasse by anaerobic digestion – A review by Silva, A.F.R., Brasil, Y.L., Koch, K., Amaral, M.C.S.

“…The increase in biofuel production by 2030, driven by the targets set at the 21st United Nations Framework Convention on Climate Change (COP21), will promote…”
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Inflammatory mediators: a causal link to hypertension during preeclampsia by Cornelius, Denise C, Cottrell, Jesse, Amaral, Lorena M, LaMarca, Babbette

“…Preeclampsia (PE) is a hypertensive disorder that occurs after 20 weeks of gestation, implicating the placenta as a key offender. PE is associated with an…”
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Formulations based on solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for cutaneous use: A review by Garcês, A., Amaral, M.H., Sousa Lobo, J.M., Silva, A.C.

“…Cutaneous use of lipid nanoparticles (solid lipid nanoparticles, SLN and nanostructured lipid carriers, NLC) has been showing promising results. These systems…”
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Protein kinases in natural versus drug reward by Amaral, Inês M., Scheffauer, Laura, Hofer, Alex, El Rawas, Rana

“…Natural and drug rewards act on the same neural pathway, the mesolimbic dopaminergic system. In brain regions such as the nucleus accumbens and ventral…”
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Role of Mitochondrial Dysfunction and Reactive Oxygen Species in Mediating Hypertension in the Reduced Uterine Perfusion Pressure Rat Model of Preeclampsia by Vaka, Venkata Ramana, McMaster, Kristen M, Cunningham, Mark W, Ibrahim, Tarek, Hazlewood, Rebekah, Usry, Nathan, Cornelius, Denise C, Amaral, Lorena M, LaMarca, Babbette

“…Placental ischemia is believed to be the initial event in the development of preeclampsia. Mitochondrial dysfunction is a cause of reactive oxygen species…”
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Wastewater treatment using microalgae: how realistic a contribution might it be to significant urban wastewater treatment? by Acién, F. Gabriel, Gómez-Serrano, C., Morales-Amaral, M. M., Fernández-Sevilla, J. M., Molina-Grima, E.

“…Microalgae have been proposed as an option for wastewater treatment since the 1960s, but still, this technology has not been expanded to an industrial scale…”
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Vanadium Compounds with Antidiabetic Potential by Amaral, Luísa M. P. F, Moniz, Tânia, Silva, André M. N, Rangel, Maria

“…Over the last four decades, vanadium compounds have been extensively studied as potential antidiabetic drugs. With the present review, we aim at presenting a…”
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Nose-to-brain delivery of lipid-based nanosystems for epileptic seizures and anxiety crisis by Costa, C., Moreira, J.N., Amaral, M.H., Sousa Lobo, J.M., Silva, A.C.

“…Epileptic seizures and anxiety crisis are severe conditions that require fast and effective treatment, targeting the brain. Current emergency antiepiletics and…”
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Is p38 MAPK Associated to Drugs of Abuse-Induced Abnormal Behaviors? by El Rawas, Rana, Amaral, Inês M, Hofer, Alex

“…The family members of the mitogen-activated protein kinases (MAPK) mediate a wide variety of cellular behaviors in response to extracellular stimuli. p38 MAPKs…”
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Sugarcane vinasse as organo-mineral fertilizers feedstock: Opportunities and environmental risks by Carpanez, T.G., Moreira, V.R., Assis, I.R., Amaral, M.C.S.

“…Fertigation using sugarcane vinasse is expected in the sugar and alcohol industries; however, its indiscriminate practice can trigger soil salinization and…”
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Sustainable ammonia resource recovery from landfill leachate by solar-driven modified direct contact membrane distillation by Zico, M.M., Ricci, B.C., Reis, B.G., Magalhães, N.C., Amaral, M.C.S.

“…[Display omitted] •Solar-driven M-DCMD was effective on recovering ammonia from landfill leachate.•98% of ammonia removal and 59% of recovery were achieved at…”
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The exercise sex gap and the impact of the estrous cycle on exercise performance in mice by Aguiar, Aderbal S., Speck, Ana Elisa, Amaral, Inês M., Canas, Paula M., Cunha, Rodrigo A.

“…Exercise physiology is different in males and females. Females are poorly studied due to the complexity of the estrous cycle and this bias has created an…”
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Temporal stratification of amyotrophic lateral sclerosis patients using disease progression patterns by M. Amaral, Daniela, Soares, Diogo F., Gromicho, Marta, de Carvalho, Mamede, Madeira, Sara C., Tomás, Pedro, Aidos, Helena

“…Identifying groups of patients with similar disease progression patterns is key to understand disease heterogeneity, guide clinical decisions and improve…”
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Social interaction reward: A resilience approach to overcome vulnerability to drugs of abuse by EL Rawas, Rana, Amaral, Inês M., Hofer, Alex

“…•Drug addiction is a disorder with stress increasing vulnerability to drug use.•Resilience is a dynamic capability that allows positive adaptation to…”
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Orexins/Hypocretins: Gatekeepers of Social Interaction and Motivation by Ouaidat, Sara, Amaral, Inês M, Monteiro, Diogo G, Harati, Hayat, Hofer, Alex, El Rawas, Rana

“…Ever since the discovery of the brain's orexin/hypocretin system, most research was directed toward unveiling its contribution to the normal functioning of…”
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