Search Results - "Amara, Rama Rao"

Enhancing SIV-specific immunity in vivo by PD-1 blockade by Vanderford, Thomas H, Velu, Vijayakumar, Titanji, Kehmia, Ahmed, Rafi, Amara, Rama Rao, Lai, Lilin, Pladevega, Annette, Freeman, Gordon J, Husain, Sajid, Zhu, Baogong, Chennareddi, Lakshmi, Silvestri, Guido

“…Chronic immunodeficiency virus infections are characterized by dysfunctional cellular and humoral antiviral immune responses. As such, immune modulatory…”
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Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection by Wrammert, Jens, Koutsonanos, Dimitrios, Li, Gui-Mei, Edupuganti, Srilatha, Sui, Jianhua, Morrissey, Michael, McCausland, Megan, Skountzou, Ioanna, Hornig, Mady, Lipkin, W Ian, Mehta, Aneesh, Razavi, Behzad, Del Rio, Carlos, Zheng, Nai-Ying, Lee, Jane-Hwei, Huang, Min, Ali, Zahida, Kaur, Kaval, Andrews, Sarah, Amara, Rama Rao, Wang, Youliang, Das, Suman Ranjan, O'Donnell, Christopher David, Yewdell, Jon W, Subbarao, Kanta, Marasco, Wayne A, Mulligan, Mark J, Compans, Richard, Ahmed, Rafi, Wilson, Patrick C

“…The 2009 pandemic H1N1 influenza pandemic demonstrated the global health threat of reassortant influenza strains. Herein, we report a detailed analysis of…”
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HIV-1 vaccination by needle-free oral injection induces strong mucosal immunity and protects against SHIV challenge by Jones, Andrew T., Shen, Xiaoying, Walter, Korey L., LaBranche, Celia C., Wyatt, Linda S., Tomaras, Georgia D., Montefiori, David C., Moss, Bernard, Barouch, Dan H., Clements, John D., Kozlowski, Pamela A., Varadarajan, Raghavan, Amara, Rama Rao

“…The oral mucosa is an attractive site for mucosal vaccination, however the thick squamous epithelium limits antigen uptake. Here we utilize a modified…”
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Multiple-Cytokine-Producing Antiviral CD4 T Cells Are Functionally Superior to Single-Cytokine-Producing Cells by KANNANGANAT, Sunil, IBEGBU, Chris, CHENNAREDDI, Lakshmi, ROBINSON, Harriet L, RAO AMARA, Rama

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Attrition of T-cell functions and simultaneous upregulation of inhibitory markers correspond with the waning of BCG-induced protection against tuberculosis in mice by Nandakumar, Subhadra, Kannanganat, Sunil, Posey, James E, Amara, Rama Rao, Sable, Suraj B

“…Mycobacterium bovis bacille Calmette-Guérin (BCG) is the most widely used live attenuated vaccine. However, the correlates of protection and waning of its…”
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Plasmacytoid dendritic cells are recruited to the colorectum and contribute to immune activation during pathogenic SIV infection in rhesus macaques by Kwa, Suefen, Kannanganat, Sunil, Nigam, Pragati, Siddiqui, Mariam, Shetty, Ravi Dyavar, Armstrong, Wendy, Ansari, Aftab, Bosinger, Steven E., Silvestri, Guido, Amara, Rama Rao

“…In SIV/HIV infection, the gastrointestinal tissue dominates as an important site because of the impact of massive mucosal CD4 depletion and immune…”
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Preclinical Studies of Human Immunodeficiency Virus/AIDS Vaccines: Inverse Correlation between Avidity of Anti-Env Antibodies and Peak Postchallenge Viremia by Zhao, Jun, Lai, Lilin, Amara, Rama Rao, Montefiori, David C, Villinger, Francois, Chennareddi, Lakshmi, Wyatt, Linda S, Moss, Bernard, Robinson, Harriet L

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Neutralization-Sensitive R5-Tropic Simian-Human Immunodeficiency Virus SHIV-2873Nip, Which Carries env Isolated from an Infant with a Recent HIV Clade C Infection by Siddappa, Nagadenahalli B, Song, Ruijiang, Kramer, Victor G, Chenine, Agnès-Laurence, Velu, Vijayakumar, Ong, Helena, Rasmussen, Robert A, Grisson, Ricky D, Wood, Charles, Zhang, Hong, Kankasa, Chipeppo, Amara, Rama Rao, Else, James G, Novembre, Francis J, Montefiori, David C, Ruprecht, Ruth M

“…Author's Correction ( vol. 83 , p. 8297 ) Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike…”
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SARS-CoV-2 RBD trimer protein adjuvanted with Alum-3M-052 protects from SARS-CoV-2 infection and immune pathology in the lung by Routhu, Nanda Kishore, Cheedarla, Narayanaiah, Bollimpelli, Venkata Satish, Gangadhara, Sailaja, Edara, Venkata Viswanadh, Lai, Lilin, Sahoo, Anusmita, Shiferaw, Ayalnesh, Styles, Tiffany M., Floyd, Katharine, Fischinger, Stephanie, Atyeo, Caroline, Shin, Sally A., Gumber, Sanjeev, Kirejczyk, Shannon, Dinnon, Kenneth H., Shi, Pei-Yong, Menachery, Vineet D., Tomai, Mark, Fox, Christopher B., Alter, Galit, Vanderford, Thomas H., Gralinski, Lisa, Suthar, Mehul S., Amara, Rama Rao

“…There is a great need for the development of vaccines that induce potent and long-lasting protective immunity against SARS-CoV-2. Multimeric display of the…”
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A modified vaccinia Ankara vector-based vaccine protects macaques from SARS-CoV-2 infection, immune pathology, and dysfunction in the lungs by Routhu, Nanda Kishore, Cheedarla, Narayanaiah, Gangadhara, Sailaja, Bollimpelli, Venkata Satish, Boddapati, Arun K., Shiferaw, Ayalnesh, Rahman, Sheikh Abdul, Sahoo, Anusmita, Edara, Venkata Viswanadh, Lai, Lilin, Floyd, Katharine, Wang, Shelly, Fischinger, Stephanie, Atyeo, Caroline, Shin, Sally A., Gumber, Sanjeev, Kirejczyk, Shannon, Cohen, Joyce, Jean, Sherrie M., Wood, Jennifer S., Connor-Stroud, Fawn, Stammen, Rachelle L., Upadhyay, Amit A., Pellegrini, Kathryn, Montefiori, David, Shi, Pei-Yong, Menachery, Vineet D., Alter, Galit, Vanderford, Thomas H., Bosinger, Steven E., Suthar, Mehul S., Amara, Rama Rao

“…A combination of vaccination approaches will likely be necessary to fully control the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic…”
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Immunogenicity and efficacy of DNA/MVA HIV vaccines in rhesus macaque models by Chea, Lynette Siv, Amara, Rama Rao

“…Despite 30 years of research on HIV, a vaccine to prevent infection and limit disease progression remains elusive. The RV144 trial showed moderate, but…”
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Tfh1 Cells in Germinal Centers During Chronic HIV/SIV Infection by Velu, Vijayakumar, Mylvaganam, Geetha, Ibegbu, Chris, Amara, Rama Rao

“…T follicular helper CD4 cells (Tfh) are essential for the development and maintenance of germinal center (GC) reactions, a critical process that promotes the…”
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PD-1 blockade during chronic SIV infection reduces hyperimmune activation and microbial translocation in rhesus macaques by Dyavar Shetty, Ravi, Velu, Vijayakumar, Titanji, Kehmia, Bosinger, Steven E, Freeman, Gordon J, Silvestri, Guido, Amara, Rama Rao

“…Hyperimmune activation is a strong predictor of disease progression during pathogenic immunodeficiency virus infections and is mediated in part by sustained…”
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DNA/MVA vaccine for HIV type 1: effects of codon-optimization and the expression of aggregates or virus-like particles on the immunogenicity of the DNA prime by Smith, James M, Amara, Rama Rao, Campbell, David, Xu, Yan, Patel, Milloni, Sharma, Sunita, Butera, Salvatore T, Ellenberger, Dennis L, Yi, Hong, Chennareddi, Lakshmi, Herndon, James G, Wyatt, Linda S, Montefiori, David, Moss, Bernard, McClure, Harold M, Robinson, Harriet L

“…Recently, a vaccine consisting of DNA priming followed by boosting with modified vaccinia Ankara (MVA) has provided long-term protection of rhesus macaques…”
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T cell vaccines for microbial infections by Robinson, Harriet L, Amara, Rama Rao

“…Vaccination, or the deliberate induction of protective immunity by administering nonpathogenic forms of a microbe or its antigens to induce a memory immune…”
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Prevention of Infection by a Granulocyte-Macrophage Colony-Stimulating Factor Co-Expressing DNA/Modified Vaccinia Ankara Simian Immunodeficiency Virus Vaccine by Lai, Lilin, Kwa, SueFen, Kozlowski, Pamela A., Montefiori, David C., Ferrari, Guido, Johnson, Welkin E., Hirsch, Vanessa, Villinger, Francois, Chennareddi, Lakshmi, Earl, Patricia L., Moss, Bernard, Amara, Rama Rao, Robinson, Harriet L.

“…A simian immunodeficiency virus (SIV) vaccine coexpressing granulocyte-macrophage colony stimulating factor (GM-CSF) prevented infection in 71% of macaques…”
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Signature for Long-Term Vaccine-Mediated Control of a Simian and Human Immunodeficiency Virus 89.6P Challenge: Stable Low-Breadth and Low-Frequency T-Cell Response Capable of Coproducing Gamma Interferon and Interleukin-2 by SADAGOPAL, Shanmugalakshmi, RAO AMARA, Rama, MONTEFIORI, David C, WYATT, Linda S, STAPRANS, Silvija I, KOZYR, Natalia L, MCCLURE, Harold M, MOSS, Bernard, ROBINSON, Harriet L

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V2 hotspot optimized MVA vaccine expressing stabilized HIV-1 Clade C envelope Gp140 delays acquisition of heterologous Clade C Tier 2 challenges in Mamu-A01 negative Rhesus Macaques by Styles, Tiffany M., Gangadhara, Sailaja, Reddy, Pradeep B. J., Sahoo, Anusmita, Shiferaw, Ayalensh, Welbourn, Sarah, Kozlowski, Pamela A., Derdeyn, Cynthia A., Velu, Vijayakumar, Amara, Rama Rao

“…Stabilized HIV envelope (Env) trimeric protein immunogens have been shown to induce strong autologous neutralizing antibody response. However, there is limited…”
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Elevated Expression Levels of Inhibitory Receptor Programmed Death 1 on Simian Immunodeficiency Virus-Specific CD8 T Cells during Chronic Infection but Not after Vaccination by VELU, Vijayakumar, KANNANGANAT, Sunil, IBEGBU, Chris, CHENNAREDDI, Lakshmi, VILLINGER, Francois, FREEMAN, Gordon J, AHMED, Rafi, RAMA RAO AMARA

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Functional MAIT Cells Are Associated With Reduced Simian-Human Immunodeficiency Virus Infection by Murugesan, Amudhan, Ibegbu, Chris, Styles, Tiffany M, Jones, Andrew T, Shanmugasundaram, Uma, Reddy, Pradeep B J, Rahman, Sadia J, Saha, Piu, Vijay-Kumar, Matam, Shankar, Esaki Muthu, Amara, Rama Rao, Velu, Vijayakumar

“…Mucosa-associated invariant T (MAIT) cells are recently characterized as a novel subset of innate-like T cells that recognize microbial metabolites as…”
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