Search Results - "Amar, Nira"
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Fatty acid synthase is preferentially degraded by autophagy upon nitrogen starvation in yeast
Published in Proceedings of the National Academy of Sciences - PNAS (03-02-2015)“…Autophagy, an evolutionarily conserved intracellular catabolic process, leads to the degradation of cytosolic proteins and organelles in the vacuole/lysosome…”
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A New Autophagy-related Checkpoint in the Degradation of an ERAD-M Target
Published in The Journal of biological chemistry (01-04-2011)“…The endoplasmic reticulum (ER) harbors elaborate quality control mechanisms to ensure proper folding and post-translational modifications of polypeptides…”
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Two newly identified sites in the ubiquitin-like protein Atg8 are essential for autophagy
Published in EMBO reports (01-06-2006)“…Atg8, a member of a novel ubiquitin‐like protein family, is an essential component of the autophagic machinery in yeast. This protein undergoes reversible…”
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Identification of Essential Residues for the C-Terminal Cleavage of the Mammalian LC3: A Lesson from Yeast Atg8
Published in Autophagy (2007)“…Atg8, a member of an evolutionarily conserved ubiquitin-like protein family, is involved in multiple membrane trafficking pathways including autophagy. In a…”
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Modulation of N-Ethylmaleimide-sensitive Factor Activity upon Amino Acid Deprivation
Published in The Journal of biological chemistry (22-04-2005)“…Adaptation of eukaryotic cells to changing environmental conditions entails rapid regulation of protein targeting and transport to specific organelles. Such…”
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Lipid droplets and their component triglycerides and steryl esters regulate autophagosome biogenesis
Published in The EMBO journal (13-08-2015)“…Autophagy is a major catabolic process responsible for the delivery of proteins and organelles to the lysosome/vacuole for degradation. Malfunction of this…”
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Potential roles of gut microbiome and metabolites in modulating ALS in mice
Published in Nature (London) (01-08-2019)“…Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disorder, in which the clinical manifestations may be influenced by genetic and unknown…”
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Interactions of Melanoma Cells with Distal Keratinocytes Trigger Metastasis via Notch Signaling Inhibition of MITF
Published in Molecular cell (20-08-2015)“…The most critical stage in initiation of melanoma metastasis is the radial to vertical growth transition, yet the triggers of this transition remain elusive…”
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