Search Results - "Amar, Marcelo J A"

A cholesterol-lowering VLP vaccine that targets PCSK9 by Crossey, Erin, Amar, Marcelo J.A, Sampson, Maureen, Peabody, Julianne, Schiller, John T, Chackerian, Bryce, Remaley, Alan T

“…Highlights • PCSK9 is a molecule that controls the metabolism of low-density lipoprotein cholesterol (LDL-C). • We have generated virus-like particles based…”
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5A apolipoprotein mimetic peptide promotes cholesterol efflux and reduces atherosclerosis in mice by Amar, Marcelo J A, D'Souza, Wilissa, Turner, Scott, Demosky, Stephen, Sviridov, Denis, Stonik, John, Luchoomun, Jayraz, Voogt, Jason, Hellerstein, Marc, Sviridov, Dmitri, Remaley, Alan T

“…Intravenous administration of apolipoprotein (apo) A-I complexed with phospholipid has been shown to rapidly reduce plaque size in both animal models and…”
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Adenoviral expression of human lecithin-cholesterol acyltransferase in nonhuman primates leads to an antiatherogenic lipoprotein phenotype by increasing high-density lipoprotein and lowering low-density lipoprotein by Amar, Marcelo J.A, Shamburek, Robert D, Vaisman, Boris, Knapper, Catherine L, Foger, Bernhard, Hoyt, Robert F, Santamarina-Fojo, Silvia, Brewer, Hollis B, Remaley, Alan T

“…Abstract Lecithin-cholesterol acyltransferase (LCAT), a key enzyme in high-density lipoprotein (HDL) metabolism, has been proposed to have atheroprotective…”
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Apolipoprotein E Negatively Regulates House Dust Mite-induced Asthma via a Low-Density Lipoprotein Receptor-mediated Pathway by XIANGLAN YAO, FREDRIKSSON, Karin, LEVINE, Stewart J, YU, Zu-Xi, XIULI XU, RAGHAVACHARI, Nalini, KEERAN, Karen J, ZYWICKE, Gayle J, KWAK, Minjung, AMAR, Marcelo J. A, REMALEY, Alan T

“…Distinct sets of corticosteroid-unresponsive genes modulate disease severity in asthma. To identify corticosteroid-unresponsive genes that provide new insights…”
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5A, an apolipoprotein A-I mimetic peptide, attenuates the induction of house dust mite-induced asthma by Yao, Xianglan, Dai, Cuilian, Fredriksson, Karin, Dagur, Pradeep K, McCoy, J Philip, Qu, Xuan, Yu, Zu-Xi, Keeran, Karen J, Zywicke, Gayle J, Amar, Marcelo J A, Remaley, Alan T, Levine, Stewart J

“…New treatment approaches are needed for patients with asthma. Apolipoprotein A-I (apoA-I), the major structural protein of high-density lipoproteins, mediates…”
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Hydrophobic amino acids in the hinge region of the 5A apolipoprotein mimetic peptide are essential for promoting cholesterol efflux by the ABCA1 transporter by Sviridov, Denis O, Andrianov, Alexander M, Anishchenko, Ivan V, Stonik, John A, Amar, Marcelo J A, Turner, Scott, Remaley, Alan T

“…The bihelical apolipoprotein mimetic peptide 5A effluxes cholesterol from cells and reduces inflammation and atherosclerosis in animal models. We investigated…”
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LCAT protects against Lipoprotein‐X formation in a murine model of drug‐induced intrahepatic cholestasis by Amar, Marcelo J. A., Freeman, Lita A., Nishida, Takafumi, Sampson, Maureen L., Pryor, Milton, Vaisman, Boris L., Neufeld, Edward B., Karathanasis, Sotirios K., Remaley, Alan T.

“…Familial lecithin:cholesterol acyltransferase (LCAT) deficiency (FLD) is a rare genetic disease characterized by low HDL‐C levels, low plasma cholesterol…”
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The ATP Binding Cassette Transporter A1 (ABCA1) Modulates the Development of Aortic Atherosclerosis in C57BL/6 and apoE-Knockout Mice by Joyce, Charles W., Marcelo J. A. Amar, Lambert, Gilles, Vaisman, Boris L., Paigen, Beverly, Najib-Fruchart, Jamila, Hoyt, Robert F., Neufeld, Edward D., Remaley, Alan T., Fredrickson, Donald S., Brewer, H. Bryan, Santamarina-Fojo, Silvia

“…Identification of mutations in the ABCA1 transporter (ABCA1) as the genetic defect in Tangier disease has generated interest in modulating atherogenic risk by…”
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A novel apolipoprotein C-II mimetic peptide that activates lipoprotein lipase and decreases serum triglycerides in apolipoprotein E-knockout mice by Amar, Marcelo J A, Sakurai, Toshihiro, Sakurai-Ikuta, Akiko, Sviridov, Denis, Freeman, Lita, Ahsan, Lusana, Remaley, Alan T

“…Apolipoprotein A-I (apoA-I) mimetic peptides are currently being developed as possible new agents for the treatment of cardiovascular disease based on their…”
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Lipolytic and ligand-binding functions of hepatic lipase protect against atherosclerosis in LDL receptor-deficient mice by Freeman, Lita, Amar, Marcelo J.A, Shamburek, Robert, Paigen, Beverly, Brewer, H. Bryan Jr, Santamarina-Fojo, Silvia, González-Navarro, Herminia

“…To elucidate the separate contributions of the lipolytic versus ligand-binding functions of hepatic lipase (HL) to lipoprotein metabolism and atherosclerosis,…”
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Trans-splicing Into Highly Abundant Albumin Transcripts for Production of Therapeutic Proteins In Vivo by Wang, Jun, Mansfield, S Gary, Cote, Colette A, Jiang, Ping Du, Weng, Ke, Amar, Marcelo JA, Brewer, Bryan H, Remaley, Alan T, McGarrity, Gerard J, Garcia-Blanco, Mariano A, Puttaraju, M

“…Spliceosome-mediated RNA trans-splicing has emerged as an exciting mode of RNA therapy. Here we describe a novel trans-splicing strategy, which targets highly…”
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Randomized double blind clinical trial on the effect of oral α-cyclodextrin on serum lipids by Amar, Marcelo J A, Kaler, Maryann, Courville, Amber B, Shamburek, Robert, Sampson, Maureen, Remaley, Alan T

“…This single center, double-blinded, cross-over, placebo controlled clinical trial investigated the effect of oral α-cyclodextrin (α-CD), a soluble dietary…”
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The Ligand-binding Function of Hepatic Lipase Modulates the Development of Atherosclerosis in Transgenic Mice by Gonzalez-Navarro, Herminia, Nong, Zengxuan, Amar, Marcelo JA, Shamburek, Robert D, Najib-Fruchart, Jamila, Paigen, Beverly J, Brewer, HBryan, Santamarina-Fojo, Silvia

“…To investigate the separate contributions of the lipolytic versus ligand-binding function of hepatic lipase (HL) to plasma lipoprotein metabolism and…”
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The Farnesoid X-receptor Is an Essential Regulator of Cholesterol Homeostasis by Lambert, Gilles, Amar, Marcelo J A, Guo, Grace, Brewer, Jr, H Bryan, Gonzalez, Frank J, Sinal, Christopher J

“…To address the importance of the farnesoid X-receptor (FXR; NR1H4) for normal cholesterol homeostasis, we evaluated the major pathways of cholesterol…”
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Effects of FXR in foam-cell formation and atherosclerosis development by Guo, Grace L., Santamarina-Fojo, Silvia, Akiyama, Taro E., Amar, Marcelo J.A., Paigen, Beverly J., Brewer, Bryan, Gonzalez, Frank J.

“…Farnesoid X receptor (FXR), a bile-acid-activated member of the nuclear receptor superfamily, is essential in regulating bile-acid, cholesterol, and…”
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Erratum to: Randomized double blind clinical trial on the effect of oral α-cyclodextrin on serum lipids by Amar, Marcelo J A, Kaler, Maryann, Courville, Amber B, Shamburek, Robert, Sampson, Maureen, Wolska, Anna, Remaley, Alan T

“…After publication of the original article [1], it came to the first author's attention that an additional contributor should have been included in the author…”
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Role of the hepatic ABCA1 transporter in modulating intrahepatic cholesterol and plasma HDL cholesterol concentrations by Basso, Federica, Freeman, Lita, Knapper, Catherine L, Remaley, Alan, Stonik, John, Neufeld, Edward B, Tansey, Terese, Amar, Marcelo J A, Fruchart-Najib, Jamila, Duverger, Nicholas, Santamarina-Fojo, Silvia, Brewer, Jr, H Bryan

“…The current model for reverse cholesterol transport proposes that HDL transports excess cholesterol derived primarily from peripheral cells to the liver for…”
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Wild-type PCSK9 inhibits LDL clearance but does not affect apoB-containing lipoprotein production in mouse and cultured cells by Lalanne, Florent, Lambert, Gilles, Amar, Marcelo J. A, Chétiveaux, Maud, Zai̊r, Yassine, Jarnoux, Anne-Laure, Ouguerram, Khadija, Friburg, José, Seidah, Nabil G, Brewer, H. Bryan, Krempf, Michel, Costet, Philippe

“…Mutations in Proprotein Convertase Subtilisin Kexin 9 (PCSK9) have been associated with autosomal dominant hypercholesterolemia. In vivo kinetic studies…”
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Hepatic ABCG5 and ABCG8 Overexpression Increases Hepatobiliary Sterol Transport but Does Not Alter Aortic Atherosclerosis in Transgenic Mice by Wu, Justina E., Basso, Federica, Shamburek, Robert D., Amar, Marcelo J.A., Vaisman, Boris, Szakacs, Gergely, Joyce, Charles, Tansey, Terese, Freeman, Lita, Paigen, Beverly J., Thomas, Fairwell, Brewer, H. Bryan, Santamarina-Fojo, Silvia

“…The individual roles of hepatic versus intestinal ABCG5 and ABCG8 in sterol transport have not yet been investigated. To determine the specific contribution of…”
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The E-box motif in the proximal ABCA1 promoter mediates transcriptional repression of the ABCA1 gene by Yang, Xiao-Ping, Freeman, Lita A, Knapper, Catherine L, Amar, Marcelo J A, Remaley, Alan, Brewer, Jr, H Bryan, Santamarina-Fojo, Silvia

“…To identify regulatory elements in the proximal human ATP-binding cassette transporter A1 (hABCA1) gene promoter we transfected RAW cells with plasmids…”
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