Search Results - "Amanullah, Ayeman"

Polyphenolic flavonoid (Myricetin) upregulated proteasomal degradation mechanisms: Eliminates neurodegenerative proteins aggregation by Joshi, Vibhuti, Mishra, Ribhav, Upadhyay, Arun, Amanullah, Ayeman, Poluri, Krishna Mohan, Singh, Sarika, Kumar, Amit, Mishra, Amit

“…Major neurodegenerative disorders are characterized by the formation of misfolded proteins aggregates inside or outside the neuronal cells. Previous studies…”
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Lanosterol Suppresses the Aggregation and Cytotoxicity of Misfolded Proteins Linked with Neurodegenerative Diseases by Upadhyay, Arun, Amanullah, Ayeman, Mishra, Ribhav, Kumar, Amit, Mishra, Amit

“…Accumulation of misfolded or aberrant proteins in neuronal cells is linked with neurodegeneration and other pathologies. Which molecular mechanisms fail and…”
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Development and Challenges of Diclofenac-Based Novel Therapeutics: Targeting Cancer and Complex Diseases by Amanullah, Ayeman, Upadhyay, Arun, Dhiman, Rohan, Singh, Sarika, Kumar, Amit, Ahirwar, Dinesh Kumar, Gutti, Ravi Kumar, Mishra, Amit

“…Diclofenac is a highly prescribed non-steroidal anti-inflammatory drug (NSAID) that relieves inflammation, pain, fever, and aches, used at different doses…”
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Indomethacin elicits proteasomal dysfunctions develops apoptosis through mitochondrial abnormalities by Amanullah, Ayeman, Mishra, Ribhav, Upadhyay, Arun, Reddy, Pothula P., Das, Ranabir, Mishra, Amit

“…Non‐steroidal anti‐inflammatory drugs (NSAIDs) are a class of drugs that are mainly used to treat pain, inflammation, and fever via cyclooxygenase‐2 (COX‐2)…”
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E3 Ubiquitin Ligases Neurobiological Mechanisms: Development to Degeneration by Upadhyay, Arun, Joshi, Vibhuti, Amanullah, Ayeman, Mishra, Ribhav, Arora, Naina, Prasad, Amit, Mishra, Amit

“…Cells regularly synthesize new proteins to replace old or damaged proteins. Deposition of various aberrant proteins in specific brain regions leads to…”
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Gp78 involvement in cellular proliferation: Can act as a promising modulator for cell cycle regulatory proteins? by Joshi, Vibhuti, Upadhyay, Arun, Chhangani, Deepak, Amanullah, Ayeman, Sharan, Rajesh N., Mishra, Amit

“…In cells, protein synthesis and degradation are normal processes, which are tightly regulated by various cellular metabolic pathways. Cellular protein quality…”
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A Decade of Boon or Burden: What Has the CHIP Ever Done for Cellular Protein Quality Control Mechanism Implicated in Neurodegeneration and Aging? by Joshi, Vibhuti, Amanullah, Ayeman, Upadhyay, Arun, Mishra, Ribhav, Kumar, Amit, Mishra, Amit

“…Cells regularly synthesize new proteins to replace old and abnormal proteins for normal cellular functions. Two significant protein quality control pathways…”
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Proteasomal Dysfunction Induced By Diclofenac Engenders Apoptosis Through Mitochondrial Pathway by Amanullah, Ayeman, Upadhyay, Arun, Chhangani, Deepak, Joshi, Vibhuti, Mishra, Ribhav, Yamanaka, Koji, Mishra, Amit

“…ABSTRACT Diclofenac is the most commonly used phenylacetic acid derivative non‐steroidal anti‐inflammatory drug (NSAID) that demonstrates significant…”
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Mahogunin ring finger 1 confers cytoprotection against mutant SOD1 aggresomes and is defective in an ALS mouse model by Chhangani, Deepak, Endo, Fumito, Amanullah, Ayeman, Upadhyay, Arun, Watanabe, Seiji, Mishra, Ribhav, Yamanaka, Koji, Mishra, Amit

“…Abstract Proteotoxicity of misfolded, disease-causing proteins is deeply implicated in the pathomechanisms for neurodegenerative diseases including copper-zinc…”
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Evidences for Piperine inhibiting cancer by targeting human G-quadruplex DNA sequences by Tawani, Arpita, Amanullah, Ayeman, Mishra, Amit, Kumar, Amit

“…Piperine, a naturally occurring alkaloid, is well known as anti-oxidant, anti-mutagenic, anti-tumor and anti-proliferative agent. Piperine exerts such…”
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Neuroepigenetics of ageing and neurodegeneration-associated dementia: An updated review by Mir, Fayaz Ahmad, Amanullah, Ayeman, Jain, Buddhi Prakash, Hyderi, Zeeshan, Gautam, Akash

“…Gene expression is tremendously altered in the brain during memory acquisition, recall, and forgetfulness. However, non-genetic factors, including…”
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Ibuprofen-based advanced therapeutics: breaking the inflammatory link in cancer, neurodegeneration, and diseases by Upadhyay, Arun, Amanullah, Ayeman, Joshi, Vibhuti, Dhiman, Rohan, Prajapati, Vijay Kumar, Poluri, Krishna Mohan, Mishra, Amit

“…Ibuprofen is a classical nonsteroidal anti-inflammatory drug (NSAID) highly prescribed to reduce acute pain and inflammation under an array of conditions,…”
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Progressing neurobiological strategies against proteostasis failure: Challenges in neurodegeneration by Amanullah, Ayeman, Upadhyay, Arun, Joshi, Vibhuti, Mishra, Ribhav, Jana, Nihar Ranjan, Mishra, Amit

“…Proteins are ordered useful cellular entities, required for normal health and organism's survival. The proteome is the absolute set of cellular expressed…”
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Ubiquitin ligase ITCH recruitment suppresses the aggregation and cellular toxicity of cytoplasmic misfolded proteins by Chhangani, Deepak, Upadhyay, Arun, Amanullah, Ayeman, Joshi, Vibhuti, Mishra, Amit

“…The protein quality control (QC) system protects cells against cellular toxicity induced by misfolded proteins and maintains overall cellular fitness…”
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Ubiquitin ligase LRSAM1 suppresses neurodegenerative diseases linked aberrant proteins induced cell death by Mishra, Ribhav, Amanullah, Ayeman, Upadhyay, Arun, Dhiman, Rohan, Dubey, Ankur Rakesh, Singh, Sarika, Prasad, Amit, Mishra, Amit

“…[Display omitted] •LRSAM1 can function as a quality control E3 Ubiquitin Ligase.•Recruitment of LRSAM1 towards misfolded proteins.•LRSAM1 levels induced under…”
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Selective multifaceted E3 ubiquitin ligases barricade extreme defense: Potential therapeutic targets for neurodegeneration and ageing by Upadhyay, Arun, Amanullah, Ayeman, Chhangani, Deepak, Mishra, Ribhav, Mishra, Amit

“…Graphical abstract The theme of “Balancing Acts of Selective Defenders: Emerging Multifaceted E3 Ubiquitin Ligases Determine Precision of Cellular fitness and…”
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Ibuprofen Induces Mitochondrial-Mediated Apoptosis Through Proteasomal Dysfunction by Upadhyay, Arun, Amanullah, Ayeman, Chhangani, Deepak, Joshi, Vibhuti, Mishra, Ribhav, Mishra, Amit

“…In routine course of life, nonsteroidal anti-inflammatory drugs (NSAIDs) are widely prescribed antipyretic, analgesic, and anti-inflammatory drugs. It is a…”
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Mahogunin Ring Finger-1 (MGRN1), a Multifaceted Ubiquitin Ligase: Recent Unraveling of Neurobiological Mechanisms by Upadhyay, Arun, Amanullah, Ayeman, Chhangani, Deepak, Mishra, Ribhav, Prasad, Amit, Mishra, Amit

“…In healthy cell, inappropriate accumulation of poor or damaged proteins is prevented by cellular quality control system. Autophagy and ubiquitin proteasome…”
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LRSAM1 E3 ubiquitin ligase promotes proteasomal clearance of E6-AP protein by Mishra, Ribhav, Joshi, Vibhuti, Upadhyay, Arun, Amanullah, Ayeman, Dubey, Ankur Rakesh, Singh, Sarika, Dubey, Vikash Kumar, Poluri, Krishna Mohan, Jana, Nihar Ranjan, Mishra, Amit

“…Numerous proteins participate and actively contribute to the various cellular mechanisms, where several of them are crucial for regular metabolism, including…”
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Mahogunin ring finger 1 suppresses misfolded polyglutamine aggregation and cytotoxicity by Chhangani, Deepak, Nukina, Nobuyuki, Kurosawa, Masaru, Amanullah, Ayeman, Joshi, Vibhuti, Upadhyay, Arun, Mishra, Amit

“…Polyglutamine diseases are a family of inherited neurodegenerative diseases caused by the expansion of CAG repeats within the coding region of target genes…”
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