Search Results - "Amanuel, Benhur"

Detectable ctDNA at the time of treatment cessation of ipilimumab and nivolumab for toxicity predicts disease progression in advanced melanoma patients by Warburton, Lydia, Reid, Anna, Amanuel, Benhur, Calapre, Leslie, Millward, Michael, Gray, Elin

“…Immune checkpoint inhibition (ICI) has led to unprecedented outcomes for melanoma patients but is associated with toxicity. ICI resumption after high grade…”
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Identification of TP53 mutations in circulating tumour DNA in high grade serous ovarian carcinoma using next generation sequencing technologies by Calapre, Leslie, Giardina, Tindaro, Beasley, Aaron B., Reid, Anna L., Stewart, Colin, Amanuel, Benhur, Meniawy, Tarek M., Gray, Elin S.

“…Plasma circulating tumour DNA (ctDNA) has been suggested to be a viable biomarker of response to treatment in patients with high grade serous ovarian carcinoma…”
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Tumour PD-L1 Expression in Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis by Acheampong, Emmanuel, Abed, Afaf, Morici, Michael, Bowyer, Samantha, Amanuel, Benhur, Lin, Weitao, Millward, Michael, Gray, Elin S

“…Antibodies against programmed death-1 (PD-1), and its ligand, (PD-L1) have been approved recently for the treatment of small-cell lung cancer (SCLC). Although…”
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Concordance of HER2 Expression in Paired Primary and Metastatic Sites of Endometrial Serous Carcinoma and the Effect of Intratumoral Heterogeneity by Yap, Francis Hong Xin, Wilson, Yancey, Peverall, Joanne, Amanuel, Benhur, Allanson, Ben, Ruba, Sukeerat

“…Primary endometrial serous carcinoma, known for its aggressive nature and poor prognosis, shares similarities with breast and gastric cancers in terms of…”
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Implementation of next generation sequencing technology for somatic mutation detection in routine laboratory practice by Giardina, Tindaro, Robinson, Cleo, Grieu-Iacopetta, Fabienne, Millward, Michael, Iacopetta, Barry, Spagnolo, Dominic, Amanuel, Benhur

“…The introduction of next generation sequencing (NGS) in the routine diagnostic setting is still in the development phase and has been limited by its…”
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Locus‐specific concordance of genomic alterations between tissue and plasma circulating tumor DNA in metastatic melanoma by Calapre, Leslie, Giardina, Tindaro, Robinson, Cleo, Reid, Anna L., Al‐Ogaili, Zeyad, Pereira, Michelle R., McEvoy, Ashleigh C., Warburton, Lydia, Hayward, Nicholas K., Khattak, Muhammad A., Meniawy, Tarek M., Millward, Michael, Amanuel, Benhur, Ziman, Melanie, Gray, Elin S.

“…Circulating tumor DNA (ctDNA) may serve as a surrogate to tissue biopsy for noninvasive identification of mutations across multiple genetic loci and for…”
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Detection of Low-level EGFR c.2369 C > T (p.Thr790Met) Resistance Mutation in Pre-treatment Non-small Cell Lung Carcinomas Harboring Activating EGFR Mutations and Correlation with Clinical Outcomes by Ye, Linda, Mesbah Ardakani, Nima, Thomas, Carla, Spilsbury, Katrina, Leslie, Connull, Amanuel, Benhur, Millward, Michael

“…Increasing evidence points to the presence of low-level de novo T790M mutations in patients with non-small cell lung carcinoma (NSCLC) harboring activating…”
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Population‐based screening for Lynch syndrome in Western Australia by Schofield, Lyn, Grieu, Fabienne, Amanuel, Benhur, Carrello, Amerigo, Spagnolo, Dominic, Kiraly, Cathy, Pachter, Nicholas, Goldblatt, Jack, Platell, Cameron, Levitt, Michael, Stewart, Colin, Salama, Paul, Ee, Hooi, Raftopoulous, Spiro, Katris, Paul, Threlfall, Tim, Edkins, Edward, Wallace, Marina, Iacopetta, Barry

“…We showed earlier that routine screening for microsatellite instability (MSI) and loss of mismatch repair (MMR) protein expression in colorectal cancer (CRC)…”
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A multisite blinded study for the detection of BRAF mutations in formalin-fixed, paraffin-embedded malignant melanoma by Richter, Anna, Grieu, Fabienne, Carrello, Amerigo, Amanuel, Benhur, Namdarian, Kateh, Rynska, Aleksandra, Lucas, Amanda, Michael, Victoria, Bell, Anthony, Fox, Stephen B., Hewitt, Chelsee A., Do, Hongdo, McArthur, Grant A., Wong, Stephen Q., Dobrovic, Alexander, Iacopetta, Barry

“…Melanoma patients with BRAF mutations respond to treatment with vemurafenib, thus creating a need for accurate testing of BRAF mutation status. We carried out…”
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Detection of EGFR mutational profile by direct dideoxy sequencing in cytology and non-cytology biopsy samples by Leslie, Connull, Giardina, Tindaro, Carrello, Amerigo, Spagnolo, Dominic V., Amanuel, Benhur

“…Epidermal growth factor receptor (EGFR) mutational analysis is recommended in the diagnostic work-up of non-small cell lung carcinoma. The first diagnostic…”
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BRAF p.Val600Glu (V600E) mutation detection in thyroid fine needle aspiration cell block samples: a feasibility study by Leslie, Connull, Grieu-Iacopetta, Fabienne, Richter, Anna, Platten, Michael, Murray, Jack, Frost, Felicity A., Amanuel, Benhur, Kumarasinghe, M. Priyanthi

“…Assessing BRAF mutation status in thyroid fine needle aspiration (FNA) cytology samples by both immunohistochemistry (IHC) and molecular methods has been…”
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Human papillomavirus and gene mutations in head and neck squamous carcinomas by Friedland, Peter, Thomas, Anitha, Naran, Anupam, Amanuel, Benhur, Grieu-Iacopetta, Fabienne, Carrello, Amerigo, Harnett, Gerald, Meyer, Christine, Phillips, Michael

“…Background:  Human papillomavirus (HPV) infection is implicated as an aetiological factor in head and neck squamous carcinomas (HNSCC), especially in the…”
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Screening for Lynch Syndrome in Young Colorectal Cancer Patients from Saudi Arabia Using Microsatellite Instability as the Initial Test by Alqahtani, Masood, Grieu, Fabienne, Carrello, Amerigo, Amanuel, Benhur, Mashour, Miral, Alattas, Rabab, Al-Saleh, Khalid, Alsheikh, Abdulmalik, Alqahtani, Sarah, Iacopetta, Barry

“…Background: Lynch Syndrome (LS) is a familial cancer condition caused by germline mutations in DNA mismatch repair genes. Individuals with LS have a greatly…”
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Cutaneous Malignant Melanoma With Rhabdomyosarcomatous Dedifferentiation: an Immunohistological and Molecular Case Study With Literature Review by O'Neill, Paul, Amanuel, Benhur, Mesbah Ardakani, Nima

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Giant Pulmonary Hamartoma: An Interesting Clinico-Pathologic Entity by Saxena, Pankaj, MCh, DNB, Downie, Stuart, BMBS, Amanuel, Benhur, FRCPA, Newman, Mark, FRACS, Konstantinov, Igor E., MD, PhD

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Cutaneous Malignant Melanoma With Rhabdomyosarcomatous Dedifferentiation: an Immunohistological and Molecular Case Study With Literature Review by O'Neill, Paul, Amanuel, Benhur, Mesbah Ardakani, Nima

“…Cutaneous malignant melanoma can show a wide range of cytomorphological variability, in particular exhibiting a rhabdoid appearance is not uncommon in melanoma…”
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Assessment of tissue and blood tumor mutational burden in patients with melanoma using a 523-gene clinical assay by Giardina, Tindaro, Humphries, Timothy, Reid, Anna, MesbahArdakani, Nima, Robinson, Cleo, Millward, Michael, Gray, Elin, Amanuel, Benhur

“…e21570 Background: High tumor mutation burden (TMB) predicts improved efficacy of immune checkpoint inhibitors (ICIs) across a range of malignancies, including…”
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PD‐L1 Expression on Circulating Tumor Cells May Be Predictive of Response to Pembrolizumab in Advanced Melanoma: Results from a Pilot Study by Khattak, Muhammad A., Reid, Anna, Freeman, James, Pereira, Michelle, McEvoy, Ashleigh, Lo, Johnny, Frank, Markus H., Meniawy, Tarek, Didan, Ali, Spencer, Isaac, Amanuel, Benhur, Millward, Michael, Ziman, Melanie, Gray, Elin

“…Background PD‐1 inhibitors are routinely used for the treatment of advanced melanoma. This study sought to determine whether PD‐L1 expression on circulating…”
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Primary adenosquamous carcinoma in a patient with Lynch syndrome by Ching, Daniel, Amanuel, Benhur, Khor, Tze Sheng

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Rectal tonsil: a diagnostic dilemma by Wang, Katie, Nyandoro, Munyaradzi G., Amanuel, Benhur, Jacob, Abraham

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