Search Results - "Amantini, D."

Pharmacological characterization of GLPG1972/S201086, a potent and selective small-molecule inhibitor of ADAMTS5 by Clement-Lacroix, P., Little, C.B., Smith, M.M., Cottereaux, C., Merciris, D., Meurisse, S., Mollat, P., Touitou, R., Brebion, F., Gosmini, R., De Ceuninck, F., Botez, I., Lepescheux, L., van der Aar, E., Christophe, T., Vandervoort, N., Blanqué, R., Comas, D., Deprez, P., Amantini, D.

“…A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5) is a key enzyme in degradation of cartilage in osteoarthritis (OA). We report the…”
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GLPG1972: a potent, selective, orally available adamts-5 inhibitor for the treatment of OA by Clement-Lacroix, P, Little, C, Meurisse, S, Blanqué, R, Mollat, P, Brebion, F, Gosmini, R, De Ceuninck, F, Botez, I, Lepescheux, L, van der Aar, E, Christophe, T, Vandervoort, N, Cottereaux, C, Comas, D, Deprez, P, Amantini, D

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New cartilage quality evaluation using bio-indentation: effect of a tool dmoad compound active in the rat MNX model by Lavet, C, Clement-Lacroix, P, Merciris, D, Meurisse, S, Lepescheux, L, Gaillard, V, Pastoureau, P, Deprez, P, Amantini, D, Ammann, P

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Efficient O-Trimethylsilylation of Alcohols and Phenols with Trimethylsilyl Azide Catalyzed by Tetrabutylammonium Bromide under Neat Conditions by Amantini, David, Fringuelli, Francesco, Pizzo, Ferdinando, Vaccaro, Luigi

“…A very efficient procedure for the trimethylsilylation of a wide variety of alcohols, including primary, allylic, benzylic, secondary, hindered secondary,…”
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Bromolysis and Iodolysis of α,β-Epoxycarboxylic Acids in Water Catalyzed by Indium Halides by Amantini, David, Fringuelli, Francesco, Pizzo, Ferdinando, Vaccaro, Luigi

“…The ring opening of α,β-epoxycarboxylic acids by bromide and iodide ions has been efficiently carried out in water in high regio- and stereoselective fashion…”
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SELECTED METHODS FOR THE REDUCTION OF THE AZIDO GROUP by Amantini, D., Fringuelli, F., Pizza, F., Vaccaro, L.

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ADAMTS-5 inhibitor GLPG1972, a potential new treatment in osteoarthritis, shows favorable safety, pharmacokinetics and pharmacodynamics in healthy subjects by van der Aar, E.M., Desrivot, J., Fagard, L., Amantini, D., Larsson, S., Struglics, A., Lohmander, S., Vanhoutte, F., Dupont, S.

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Synthesis of 4-Aryl-1H-1,2,3-triazoles through TBAF-Catalyzed [3 + 2] Cycloaddition of 2-Aryl-1-nitroethenes with TMSN3 under Solvent-Free Conditions by Amantini, David, Fringuelli, Francesco, Piermatti, Oriana, Pizzo, Ferdinando, Zunino, Ennio, Vaccaro, Luigi

“…TBAF-catalyzed [3 + 2] cycloaddition reactions of 2-aryl-1-cyano- or 2-aryl-1-carbethoxy-1-nitroethenes 1 with TMSN3 under SFC allow the corresponding…”
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Blepharo-cheilo-dontic (BCD) syndrome: Report on four new patients by Guion-Almeida, M.L., Rodini, E.S.O., Kokitsu-Nakata, N.M., Bologna-Amantini, D.

“…We report on four Brazilian patients with, among other signs, cleft lip and palate, dental anomalies, ectropion of the lower eyelids, euryblepharon, and…”
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ADAMTS-5 inhibition with the potent and highly selective inhibitor GLPG1972 results in strong disease-modifying OA drug effects in the rat meniscectomy model by Clement-Lacroix, P., Meurisse, S., Lepescheux, L., Merciris, D., Borgonovi, M., Cottereaux, C., Mollat, P., Brebion, F., Gosmini, R., De Ceuninck, F., Botez, I., Christophe, T., van der Aar, E.E., Vandervoort, N., Blanqué, R., Comas, D., Deprez, P., Amantini, D.

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3-Nitrocoumarins as Dienophiles in the Diels−Alder Reaction in Water. An Approach to the Synthesis of Nitrotetrahydrobenzo[c]chromenones and Dihydrodibenzo[b,d]furans by Amantini, David, Fringuelli, Francesco, Piermatti, Oriana, Pizzo, Ferdinando, Vaccaro, Luigi

“…The [4 + 2] cycloadditions of 3-nitrocoumarin (1a), 6-chloro-3-nitrocoumarin (1b), and 6-, 7-, and 8-hydroxy-3-nitrocoumarins (1c, 5, and 6) with…”
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Uncatalyzed [4 + 2] Cycloadditions of 3-Nitrocoumarins with Vinyl Ethers in Solventless Conditions. A New Entry to Chromene Derivatives by Amantini, David, Fringuelli, Francesco, Pizzo, Ferdinando

“…The [4 + 2] cycloadditions of 3-nitrocoumarins 5 with electron-rich dienophiles (ethyl vinyl ether (8), 2,3-dihydrofuran (9), and 3,4-dihydro-2H-pyran (10))…”
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Nucleophilic ring opening of 1,2-epoxides in aqueous medium by Amantini, David, Fringuelli, Francesco, Piermatti, Oriana, Tortoioli, Simone, Vaccaro, Luigi

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Cerebral Fat Embolism After Video-Assisted Thoracic Surgery by Scarpino, Maenia, MD, Lanzo, Giovanni, Tch, Cappelli, Francesco, MD, Moretti, Marco, MD, Misuri, Gianni, MD, Voltolini, Luca, MD, Pistolesi, Massimo, MD, Amantini, Aldo, MD, Grippo, Antonello, MD

“…Cerebral fat embolism (CFE) is an uncommon disease occurring mainly after traumatic lower limb long bone fractures. A 64-year-old woman with pneumonia and…”
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Cortical Blindness After Cardiac Surgery: Just an Ischemic Mechanism? by Scarpino, Maenia, MD, Olivo, Giuseppe, MD, Quilghini, Pietro, MD, Lanzo, Giovanni, Phd, Moretti, Marco, MD, Carrai, Riccardo, MD, Fontanari, Paolo, MD, Amantini, Aldo, MD, Grippo, Antonello, MD

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