Search Results - "Amantea, Christopher M"

ERK5 kinase activity is dispensable for cellular immune response and proliferation by Lin, Emme C. K., Amantea, Christopher M., Nomanbhoy, Tyzoon K., Weissig, Helge, Ishiyama, Junichi, Hu, Yi, Sidique, Shyama, Li, Bei, Kozarich, John W., Rosenblum, Jonathan S.

“…Unlike other members of the MAPK family, ERK5 contains a large C-terminal domain with transcriptional activation capability in addition to an N-terminal…”
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Osteogenic oxysterols inhibit the adverse effects of oxidative stress on osteogenic differentiation of marrow stromal cells by Shouhed, Daniel, Kha, Hoa Ton, Richardson, Jennifer A., Amantea, Christopher M., Hahn, Theodore J., Parhami, Farhad

“…The osteoporosis that occurs with aging is associated with reduced number and activity of osteoblastic cells. Aging, menopause, and osteoporosis are correlated…”
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20(S)‐Hydroxycholesterol Inhibits PPARγ Expression and Adipogenic Differentiation of Bone Marrow Stromal Cells Through a Hedgehog‐Dependent Mechanism by Kim, Woo‐Kyun, Meliton, Vicente, Amantea, Christopher M, Hahn, Theodore J, Parhami, Farhad

“…Specific oxysterols have been shown to be pro‐osteogenic and anti‐adipogenic. However, the molecular mechanism(s) by which oxysterols inhibit adipogenic…”
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Oxysterol-induced osteogenic differentiation of marrow stromal cells is regulated by Dkk-1 inhibitable and PI3-kinase mediated signaling by Amantea, Christopher M., Kim, Woo-Kyun, Meliton, Vicente, Tetradis, Sotirios, Parhami, Farhad

“…Osteoporosis and its complications cause morbidity and mortality in the aging population, and result from increased bone resorption by osteoclasts in parallel…”
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Oxysterols enhance osteoblast differentiation in vitro and bone healing in vivo by Aghaloo, Tara L., Amantea, Christopher M., Cowan, Catherine M., Richardson, Jennifer A., Wu, Ben M., Parhami, Farhad, Tetradis, Sotirios

“…Oxysterols, naturally occurring cholesterol oxidation products, can induce osteoblast differentiation. Here, we investigated short‐term…”
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Amides of 4-hydroxy-8-methanesulfonylamino-quinoline-2-carboxylic acid as zinc-dependent inhibitors of Lp-PLA by Hu, Yi, Lin, Emme C K, Pham, Lan M, Cajica, Julia, Amantea, Christopher M, Okerberg, Eric, Brown, Heidi E, Fraser, Allister, Du, Lingling, Kohno, Yasushi, Ishiyama, Junichi, Kozarich, John W, Shreder, Kevin R

“…AX10479, the phenyl amide of 4-hydroxy-8-methanesulfonylamino-quinoline-2-carboxylic acid, was identified as a Zn(2+)-dependent, 27nM inhibitor of human plasma…”
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Oxysterol-induced osteoblastic differentiation of pluripotent mesenchymal cells is mediated through a PKC- and PKA-dependent pathway by Richardson, Jennifer A., Amantea, Christopher M., Kianmahd, Benjamin, Tetradis, Sotirios, Lieberman, Jay R., Hahn, Theodore J., Parhami, Farhad

“…Oxysterols form a large family of oxygenated derivatives of cholesterol that are present in circulation, and in human and animal tissues. The discovery of…”
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Amides of xanthurenic acid as zinc-dependent inhibitors of Lp-PLA by Lin, Emme C.K, Hu, Yi, Amantea, Christopher M, Pham, Lan M, Cajica, Julia, Okerberg, Eric, Brown, Heidi E, Fraser, Allister, Du, Lingling, Kohno, Yasushi, Ishiyama, Junichi, Kozarich, John W, Shreder, Kevin R

“…AX10185, the phenyl amide of xanthurenic acid, was found to be a sub-100nM inhibitor of Lp-PLA₂. However, in the presence of EDTA the inhibitory activity of…”
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Synthesis and structure–activity relationship of (1-halo-2-naphthyl) carbamate-based inhibitors of KIAA1363 (NCEH1/AADACL1) by Shreder, Kevin R., Lin, Emme C.K., Wu, Jiangyue, Cajica, Julia, Amantea, Christopher M., Hu, Yi, Okerberg, Eric, Brown, Heidi E., Pham, Lan M., Chung, De Michael, Fraser, Allister S., McGee, Ethel, Rosenblum, Jonathan S., Kozarich, John W.

“…KIAA1363 is a serine hydrolase whose activity has been shown to be positively associated with tumor cell invasiveness. Thus, inhibitors of KIAA1363 represent a…”
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Amides of xanthurenic acid as zinc-dependent inhibitors of Lp-PLA2 by Lin, Emme C.K., Hu, Yi, Amantea, Christopher M., Pham, Lan M., Cajica, Julia, Okerberg, Eric, Brown, Heidi E., Fraser, Allister, Du, Lingling, Kohno, Yasushi, Ishiyama, Junichi, Kozarich, John W., Shreder, Kevin R.

“…AX10185, the phenyl amide of xanthurenic acid, was found to be a sub-100nM inhibitor of Lp-PLA2. However, in the presence of EDTA the inhibitory activity of…”
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Abstract 1415: Reduction in photoimmunotherapy-induced edema with COX-2 inhibition: Combatting clinically relevant adverse events without compromising efficacy by Ma, Gina, Gordon, Myra, Lapetoda, Jason, Lozano, Abram, Amantea, Christopher M., Osada, Takuya, Thorne, Amy H.

“…Abstract ASP-1929 photoimmunotherapy (PIT), an investigational drug-device combination, consists of an epithelial growth factor receptor (EGFR)-targeting drug,…”
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Amides of 4-hydroxy-8-methanesulfonylamino-quinoline-2-carboxylic acid as zinc-dependent inhibitors of Lp-PLA2 by Hu, Yi, Lin, Emme C.K., Pham, Lan M., Cajica, Julia, Amantea, Christopher M., Okerberg, Eric, Brown, Heidi E., Fraser, Allister, Du, Lingling, Kohno, Yasushi, Ishiyama, Junichi, Kozarich, John W., Shreder, Kevin R.

“…AX10479, the phenyl amide of 4-hydroxy-8-methanesulfonylamino-quinoline-2-carboxylic acid, was identified as a Zn2+-dependent, 27nM inhibitor of human plasma…”
Get full text

20(S)-hydroxycholesterol inhibits PPARgamma expression and adipogenic differentiation of bone marrow stromal cells through a hedgehog-dependent mechanism by Kim, Woo-Kyun, Meliton, Vicente, Amantea, Christopher M, Hahn, Theodore J, Parhami, Farhad

“…Specific oxysterols have been shown to be pro-osteogenic and anti-adipogenic. However, the molecular mechanism(s) by which oxysterols inhibit adipogenic…”
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Amides of xanthurenic acid as zinc-dependent inhibitors of Lp-PL by Lin, Emme CK, Hu, Yi, Amantea, Christopher M, Pham, Lan M, Cajica, Julia, Okerberg, Eric, Brown, Heidi E, Fraser, Allister, Du, Lingling, Kohno, Yasushi, Ishiyama, Junichi, Kozarich, John W, Shreder, Kevin R, Burstein, Sumner, McQuain, Catherine, Salmonsen, Rebecca, Seicol, Benjamin

“…Several N-linked amino acid-linoleic acid conjugates were studied for their potential as anti inflammatory agents. The parent molecule, N-linoleoylglycine was…”
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