Search Results - "Amann, Philipp M"

Control of the Physical and Antimicrobial Skin Barrier by an IL-31-IL-1 Signaling Network by Hänel, Kai H, Pfaff, Carolina M, Cornelissen, Christian, Amann, Philipp M, Marquardt, Yvonne, Czaja, Katharina, Kim, Arianna, Lüscher, Bernhard, Baron, Jens M

“…Atopic dermatitis, a chronic inflammatory skin disease with increasing prevalence, is closely associated with skin barrier defects. A cytokine related to…”
Get full text

Effects of a ceramide‐containing water‐in‐oil ointment on skin barrier function and allergen penetration in an IL‐31 treated 3D model of the disrupted skin barrier by Huth, Sebastian, Schmitt, Laurenz, Marquardt, Yvonne, Heise, Ruth, Lüscher, Bernhard, Amann, Philipp M., Baron, Jens M.

“…Atopic dermatitis (AD) is a chronically relapsing, pruritic inflammation of the skin with dryness and disturbed skin barrier function. Recently, we established…”
Get full text

N-Cyano Sulfoximines: COX Inhibition, Anticancer Activity, Cellular Toxicity, and Mutagenicity by Park, Seong Jun, Baars, Hannah, Mersmann, Stefanie, Buschmann, Helmut, Baron, Jens Malte, Amann, Philipp M., Czaja, Katharina, Hollert, Henner, Bluhm, Kerstin, Redelstein, Regine, Bolm, Carsten

“…From insects to cancer: N‐Cyano sulfoximines were evaluated for COX inhibition and antiproliferative activity against a panel of cancer cell lines. The most…”
Get full text

Hyperpigmentation and higher incidence of cutaneous malignancies in moderate-high PCB- and dioxin exposed individuals by Leijs, Marike M., Esser, André, Amann, Philipp M., Schettgen, Thomas, Gube, Monika, Merk, Hans F., Kraus, Thomas, Baron, Jens M.

“…Polychlorinated biphenyls (PCB) are well known persistent and toxic environmental pollutants. Our aim was to identify effects of moderate-high exposure to…”
Get full text

Novel Human Full-Thickness Three-Dimensional Nonkeratinized Mucous Membrane Model for Pharmacological Studies in Wound Healing by Schmitt, Laurenz, Marquardt, Yvonne, Heise, Ruth, von Felbert, Verena, Amann, Philipp M, Huth, Laura, Steiner, Timm, Hölzle, Frank, Huth, Sebastian, Baron, Jens Malte

“…Efforts are increasingly aiming to develop in vitro models that can provide effective alternatives to in vivo experiments. The main aim of this study was the…”
Get more information

Interferon Alpha Signalling and Its Relevance for the Upregulatory Effect of Transporter Proteins Associated with Antigen Processing (TAP) in Patients with Malignant Melanoma by Heise, Ruth, Amann, Philipp M, Ensslen, Silke, Marquardt, Yvonne, Czaja, Katharina, Joussen, Sylvia, Beer, Daniel, Abele, Rupert, Plewnia, Gabriele, Tampé, Robert, Merk, Hans F, Hermanns, Heike M, Baron, Jens M

“…Interferon alpha (IFNα) is routinely used in the clinical practice for adjuvant systemic melanoma therapy. Understanding the molecular mechanism of IFNα…”
Get full text

Molecular Genetic Screening in Patients With ACE Inhibitor/Angiotensin Receptor Blocker-Induced Angioedema to Explore the Role of Hereditary Angioedema Genes by Mathey, Carina M., Maj, Carlo, Scheer, Annika B., Fazaal, Julia, Wedi, Bettina, Wieczorek, Dorothea, Amann, Philipp M., Löffler, Harald, Koch, Lukas, Schöffl, Clemens, Dickel, Heinrich, Ganjuur, Nomun, Hornung, Thorsten, Forkel, Susann, Greve, Jens, Wurpts, Gerda, Hallberg, Pär, Bygum, Anette, Von Buchwald, Christian, Karawajczyk, Malgorzata, Steffens, Michael, Stingl, Julia, Hoffmann, Per, Heilmann-Heimbach, Stefanie, Mangold, Elisabeth, Ludwig, Kerstin U., Rasmussen, Eva R., Wadelius, Mia, Sachs, Bernhardt, Nöthen, Markus M., Forstner, Andreas J.

“…Angioedema is a relatively rare but potentially life-threatening adverse reaction to angiotensin-converting enzyme inhibitors (ACEi) and angiotensin receptor…”
Get full text

Understanding the impact of risankizumab on keratinocyte-derived IL-23A in a novel organotypic 3D skin model containing IL-23A responsive and IL-17A producing γδ-T-cells by Huth, Laura, Amann, Philipp M, Marquardt, Yvonne, Jansen, Manuela, Baron, Jens Malte, Huth, Sebastian

“…PurposeTo study the effects of the anti-IL-23A antibody risankizumab on the IL-36γ/IL-23A/IL-17A signaling cascade we used a newly developed 3D skin model…”
Get full text

Retinoid treatment of skin diseases by Beckenbach, Lisa, Baron, Jens M., Merk, Hans F., Löffler, Harald, Amann, Philipp M.

“…Retinoids (vitamin A and its metabolites) are potent natural regulators of cellular activities, including cell growth and differentiation, and they mediate…”
Get full text

Expression of CYP1A1, CYP1B1 and IL-1β in PBMCs and skin samples of PCB exposed individuals by Leijs, Marike M., Esser, André, Amann, Philipp M., Schettgen, Thomas, Heise, Ruth, Fietkau, Katharina, Gube, Monika, Merk, Hans F., Kraus, Thomas, Baron, Jens M.

“…Polychlorinated biphenyls (PCBs) are well- known man-made persistent environmental pollutants and endocrine disruptors. As a result of mass production in the…”
Get full text

Characterization of a novel standardized human three-dimensional skin wound healing model using non-sequential fractional ultrapulsed CO2 laser treatments by Marquardt, Yvonne, Amann, Philipp M., Heise, Ruth, Czaja, Katharina, Steiner, Timm, Merk, Hans F., Skazik-Voogt, Claudia, Baron, Jens M.

“…Background and Objective At present, there is no standardized in vitro human skin model for wound healing. Therefore, our aim was to establish and characterize…”
Get full text

Altered Gene Expression in Dioxin-Like and Non-Dioxin-Like PCB Exposed Peripheral Blood Mononuclear Cells by Leijs, Marike M, Gan, Lin, De Boever, Patrick, Esser, André, Amann, Philipp M, Ziegler, Patrick, Fietkau, Katharina, Schettgen, Thomas, Kraus, Thomas, Merk, Hans F, Baron, Jens M

“…Polychlorinated biphenyls (PCBs) are well known carcinogenic persistent environmental pollutants and endocrine disruptors. Our aim was to identify the possible…”
Get full text

Ablative non-sequential fractional ultrapulsed CO2 laser pretreatment improves conventional photodynamic therapy with methyl aminolevulinate in a novel human in vitro 3D actinic keratosis skin model by Huth, Sebastian, Marquardt, Yvonne, Amann, Philipp M., Leverkus, Martin, Huth, Laura, Baron, Jens M., Gerber, Peter A.

Get full text

Effects of non-ablative fractional erbium glass laser treatment on gene regulation in human three-dimensional skin models by Amann, Philipp M., Marquardt, Yvonne, Steiner, Timm, Hölzle, Frank, Skazik-Voogt, Claudia, Heise, Ruth, Baron, Jens M.

“…Clinical experiences with non-ablative fractional erbium glass laser therapy have demonstrated promising results for dermal remodelling and for the indications…”
Get full text

Alitretinoin (9-cis retinoic acid) is effective against pityriasis rubra pilaris: a retrospective clinical study by Amann, Philipp M, Susic, Marijan, Glüder, Franziska, Berger, Hans, Krapf, Wolfgang, Löffler, Harald

“…Pityriasis rubra pilaris (PRP) is an uncommon cutaneous disease with disorder of keratinisation. Up to now, systemic retinoids like acitretin or isotretinoin…”
Get full text

Downregulation of STRA6 Expression in Epidermal Keratinocytes Leads to Hyperproliferation-Associated Differentiation in Both In Vitro and In Vivo Skin Models by Skazik, Claudia, Amann, Philipp M., Heise, Ruth, Marquardt, Yvonne, Czaja, Katharina, Kim, Arianna, Rühl, Ralph, Kurschat, Peter, Merk, Hans F., Bickers, David R., Baron, Jens M.

“…Retinoids are known to affect skin cell proliferation and differentiation and are key molecules that target retinoid and retinoic acid receptors (RXRs and…”
Get full text

Ablative non-sequential fractional ultrapulsed CO 2 laser pretreatment improves conventional photodynamic therapy with methyl aminolevulinate in a novel human in vitro 3D actinic keratosis skin model by Huth, Sebastian, Marquardt, Yvonne, Amann, Philipp M, Leverkus, Martin, Huth, Laura, Baron, Jens M, Gerber, Peter A

Get full text

Vitamin A metabolism in benign and malignant melanocytic skin cells: Importance of lecithin/retinol acyltransferase and RPE65 by Amann, Philipp M., Luo, Chonglin, Owen, Robert W., Hofmann, Claudia, Freudenberger, Muriel, Schadendorf, Dirk, Eichmüller, Stefan B., Bazhin, Alexandr V.

“…Disturbance in vitamin A metabolism seems to be an important attribute of cancer cells. Retinoids, particularly retinoic acid, have critical regulatory…”
Get full text

LRAT overexpression diminishes intracellular levels of biologically active retinoids and reduces retinoid antitumor efficacy in the murine melanoma B16F10 cell line by Amann, Philipp M, Czaja, Katharina, Bazhin, Alexandr V, Rühl, Ralph, Eichmüller, Stefan B, Merk, Hans F, Baron, Jens M

“…Vitamin A (all- trans -retinol, ATRol) serves as a precursor for all- trans -retinoic acid (ATRA), a ligand for the retinoic acid receptor (RAR), representing…”
Get more information

Lecithin retinol acyltransferase as a potential prognostic marker for malignant melanoma by Hassel, Jessica C., Amann, Philipp M., Schadendorf, Dirk, Eichmüller, Stefan B., Nagler, Markus, Bazhin, Alexandr V.

“…Metabolism inside cells differs between cancer and normal cells. Because disturbance of vitamin A metabolism might be important, we investigated expression of…”
Get full text