Search Results - "Amand, Séverine"

Metabolic Investigation and Auxiliary Enzyme Modelization of the Pyrrocidine Pathway Allow Rationalization of Paracyclophane-Decahydrofluorene Formation by Chen, Youwei, Sewsurn, Steffi, Amand, Séverine, Kunz, Caroline, Pietrancosta, Nicolas, Calabro, Kevin, Buisson, Didier, Mann, Stéphane

“…Fungal paracyclophane-decahydrofluorene-containing natural products are complex polycyclic metabolites derived from similar hybrid PKS-NRPS pathways. Herein we…”
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Automated Detection of Natural Halogenated Compounds from LC‑MS Profiles–Application to the Isolation of Bioactive Chlorinated Compounds from Marine-Derived Fungi by Roullier, Catherine, Guitton, Yann, Valery, Marine, Amand, Séverine, Prado, Soizic, Robiou du Pont, Thibaut, Grovel, Olivier, Pouchus, Yves François

“…A collection of culture extracts obtained from several marine-derived fungal strains collected on the French Atlantic coast was investigated by high…”
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A Reactive Eremophilane and Its Antibacterial 2(1H)‑Naphthalenone Rearrangement Product, Witnesses of a Microbial Chemical Warfare by Amand, Séverine, Vallet, Marine, Guedon, Laura, Genta-Jouve, Grégory, Wien, Frank, Mann, Stéphane, Dupont, Joëlle, Prado, Soizic, Nay, Bastien

“…Two sesquiterpenes, 4-epi-microsphaeropsisin (1) and a dihydrofurano-2­(1H)-naphthalenone (variabilone, 2) which represents a new skeleton, were isolated from…”
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The fungal leaf endophyte Paraconiothyrium variabile specifically metabolizes the host-plant metabolome for its own benefit by Tian, Yuan, Amand, Séverine, Buisson, Didier, Kunz, Caroline, Hachette, François, Dupont, Joëlle, Nay, Bastien, Prado, Soizic

“…Impact of an endophytic fungus on the leaf secondary metabolome of its host-plant was monitored through metabolomic approaches followed by structural…”
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Optimized approach for the identification of highly efficient correctors of nonsense mutations in human diseases by Benhabiles, Hana, Gonzalez-Hilarion, Sara, Amand, Séverine, Bailly, Christine, Prévotat, Anne, Reix, Philippe, Hubert, Dominique, Adriaenssens, Eric, Rebuffat, Sylvie, Tulasne, David, Lejeune, Fabrice

“…About 10% of patients with a genetic disease carry a nonsense mutation causing their pathology. A strategy for correcting nonsense mutations is premature…”
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Guaiane Sesquiterpenes from Biscogniauxia nummularia Featuring Potent Antigerminative Activity by Amand, Séverine, Langenfeld, Aude, Blond, Alain, Dupont, Joëlle, Nay, Bastien, Prado, Soizic

“…Xylaranone, a previously unreported guaiane sesquiterpene along with the known terpenoid xylaranol B and the two mellein derivatives…”
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Use of 2,6-diaminopurine as a potent suppressor of UGA premature stop codons in cystic fibrosis by Leroy, Catherine, Spelier, Sacha, Essonghe, Nadège Charlene, Poix, Virginie, Kong, Rebekah, Gizzi, Patrick, Bourban, Claire, Amand, Séverine, Bailly, Christine, Guilbert, Romain, Hannebique, David, Persoons, Philippe, Arhant, Gwenaëlle, Prévotat, Anne, Reix, Philippe, Hubert, Dominique, Gérardin, Michèle, Chamaillard, Mathias, Prevarskaya, Natalia, Rebuffat, Sylvie, Shapovalov, George, Beekman, Jeffrey, Lejeune, Fabrice

“…Nonsense mutations are responsible for around 10% of cases of genetic diseases, including cystic fibrosis. 2,6-diaminopurine (DAP) has recently been shown to…”
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Direct biosynthetic cyclization of a distorted paracyclophane highlighted by double isotopic labelling of L-tyrosine by Ear, Alexandre, Amand, Séverine, Blanchard, Florent, Blond, Alain, Dubost, Lionel, Buisson, Didier, Nay, Bastien

“…The biosynthesis of pyrrocidines, fungal PK-NRP compounds featuring a strained [9]paracyclophane, was investigated in Acremonium zeae. We used a synthetic…”
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Identification of novel Zika virus NS3 protease inhibitors with different inhibition modes by integrative experimental and computational approaches by Andrade, Milene Aparecida, Mottin, Melina, Sousa, Bruna K.de P., Barbosa, João Alexandre Ribeiro Gonçalves, dos Santos Azevedo, Clênia, Lasse Silva, Camila, Gonçalves de Andrade, Marina, Motta, Flávia Nader, Maulay-Bailly, Christine, Amand, Séverine, Santana, Jaime Martins de, Horta Andrade, Carolina, Grellier, Philippe, Bastos, Izabela M.D.

“…Zika virus (ZIKV) infection is associated with severe neurological disorders and congenital malformation. Despite efforts to eradicate the disease, there is…”
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Identification of Novel Inhibitors of DNA Methylation by Screening of a Chemical Library by Ceccaldi, Alexandre, Rajavelu, Arumugam, Ragozin, Sergey, Sénamaud-Beaufort, Catherine, Bashtrykov, Pavel, Testa, Noé, Dali-Ali, Hana, Maulay-Bailly, Christine, Amand, Séverine, Guianvarc’h, Dominique, Jeltsch, Albert, Arimondo, Paola B

“…In order to discover new inhibitors of the DNA methyltransferase 3A/3L complex, we used a medium-throughput nonradioactive screen on a random collection of…”
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Natural aristolactams and aporphine alkaloids as inhibitors of CDK1/cyclin B and DYRK1A by Marti, Guillaume, Eparvier, Véronique, Morleo, Barbara, Le Ven, Jessica, Apel, Cécile, Bodo, Bernard, Amand, Séverine, Dumontet, Vincent, Lozach, Olivier, Meijer, Laurent, Guéritte, Françoise, Litaudon, Marc

“…In an effort to find potent inhibitors of the protein kinases DYRK1A and CDK1/Cyclin B, a systematic in vitro evaluation of 2,500 plant extracts from New…”
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2,6-Diaminopurine as a highly potent corrector of UGA nonsense mutations by Trzaska, Carole, Amand, Séverine, Bailly, Christine, Leroy, Catherine, Marchand, Virginie, Duvernois-Berthet, Evelyne, Saliou, Jean-Michel, Benhabiles, Hana, Werkmeister, Elisabeth, Chassat, Thierry, Guilbert, Romain, Hannebique, David, Mouray, Anthony, Copin, Marie-Christine, Moreau, Pierre-Arthur, Adriaenssens, Eric, Kulozik, Andreas, Westhof, Eric, Tulasne, David, Motorin, Yuri, Rebuffat, Sylvie, Lejeune, Fabrice

“…Nonsense mutations cause about 10% of genetic disease cases, and no treatments are available. Nonsense mutations can be corrected by molecules with nonsense…”
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Ciliate Nassula sp. grazing on a microcystin-producing cyanobacterium (Planktothrix agardhii): impact on cell growth and in the microcystin fractions by Combes, Audrey, Dellinger, Marc, Cadel-six, Sabrina, Amand, Severine, Comte, Katia

“…► Interactions of free-living ciliates and toxic cyanobacteria. ► Ciliates can survive and grow on toxic diet of Planktothrix agardhii over an extended period…”
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