Search Results - "Amala, Mathimaran"
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In silico approaches for the identification of potential allergens among hypothetical proteins from Alternaria alternata and its functional annotation
Published in Scientific reports (20-03-2024)“…Direct exposure to the fungal species Alternaria alternata is a major risk factor for the development of asthma, allergic rhinitis, and inflammation. As of…”
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Functional Characterization, Mechanism, and Mode of Action of Putative Streptomycin Adenylyltransferase from Serratia marcescens
Published in Antibiotics (Basel) (30-11-2022)“…Nosocomial infections are serious threats to the entire world in healthcare settings. The major causative agents of nosocomial infections are bacterial…”
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Identification of anti-filarial leads against aspartate semialdehyde dehydrogenase of Wolbachia endosymbiont of Brugia malayi: combined molecular docking and molecular dynamics approaches
Published in Journal of biomolecular structure & dynamics (22-01-2019)“…Lymphatic filariasis is a debilitating vector borne parasitic disease that infects human lymphatic system by nematode Brugia malayi. Currently available…”
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Deciphering the pH-dependent oligomerization of aspartate semialdehyde dehydrogenase from Wolbachia endosymbiont of Brugia malayi: An in vitro and in silico approaches
Published in International journal of biological macromolecules (01-09-2024)“…The enzyme aspartate semialdehyde dehydrogenase (ASDH) plays a pivotal role in the amino acid biosynthesis pathway, making it an attractive target for the…”
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Unveiling the intricacies of allosteric regulation in aspartate kinase from the Wolbachia endosymbiont of Brugia Malayi: Mechanistic and therapeutic insights
Published in International journal of biological macromolecules (01-05-2024)“…Aspartate kinase (AK), an enzyme from the Wolbachia endosymbiont of Brugia malayi (WBm), plays a pivotal role in the bacterial cell wall and amino acid…”
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Functional significance of mouse seminal vesicle sulfhydryl oxidase on sperm capacitation in vitro
Published in Molecular human reproduction (29-08-2022)“…Abstract During ejaculation, cauda epididymal spermatozoa are suspended in a protein-rich solution of seminal plasma, which is composed of proteins mostly…”
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Molecular evolution, binding site interpretation and functional divergence of aspartate semialdehyde dehydrogenase
Published in Journal of biomolecular structure & dynamics (03-05-2022)“…Aspartate Semialdehyde Dehydrogenase (ASDH) is an important enzyme essential for the viability of pathogenic microorganisms. ASDH is mainly involved in amino…”
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Characterization of putative transcriptional regulator (PH0140) and its distal homologue
Published in Cellular signalling (01-08-2021)“…In this study, a phylogenetic tree was constructed using 1854 sequences of various Lrp/AnsC (FFRPs) and ArsR proteins from pathogenic and non-pathogenic…”
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Structural and functional characterization of 6-phosphogluconate dehydrogenase in Plasmodium falciparum (3D7) and identification of its potent inhibitors
Published in Journal of biomolecular structure & dynamics (03-03-2024)“…The malarial parasite Plasmodium falciparum predominantly causes severe malaria and deaths worldwide. Moreover, resistance developed by P. falciparum to…”
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Functional Characterization, Mechanism, and Mode of Action of Putative Streptomycin Adenylyltransferase from ISerratia marcescens/I
Published in Antibiotics (Basel) (01-11-2022)“…Nosocomial infections are serious threats to the entire world in healthcare settings. The major causative agents of nosocomial infections are bacterial…”
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Synthesis of multifunctional silver oxide, zinc oxide, copper oxide and gold nanoparticles for enhanced antibacterial activity against ESKAPE pathogens and antioxidant, anticancer activities using Momordica cymbalaria seed extract
Published in Materials today communications (01-06-2024)“…Rising emergence in public health due to antibiotic-resistant of ESKAPE pathogens, diseases related to oxidative damage and cancer has driven the urgent need…”
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Purification, crystallization, and X‐ray diffraction analysis of succinyl‐diaminopimelate desuccinylase from Wolbachia endosymbiont of Brugia malayi
Published in Journal of the Chinese Chemical Society (Taipei) (01-05-2023)“…Lymphatic filariasis (LF) is a debilitating mosquito‐borne parasitic disease caused by Brugia malayi in humans in the lymphatic system. Although limited drugs…”
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