Search Results - "Amako, Yuka"

Small Molecule Interactome Mapping by Photoaffinity Labeling Reveals Binding Site Hotspots for the NSAIDs by Gao, Jinxu, Mfuh, Adelphe, Amako, Yuka, Woo, Christina M

“…Many therapeutics elicit cell-type specific polypharmacology that is executed by a network of molecular recognition events between a small molecule and the…”
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Hydrocyanative Cyclization and Three-Component Cross-Coupling Reaction between Allenes and Alkynes under Nickel Catalysis by Arai, Shigeru, Amako, Yuka, Yang, Xiaofei, Nishida, Atsushi

“…Packed with functionality: The key step in the title reactions with acetone cyanohydrin is a regioselective hydronickelation of allenes. Subsequent…”
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Regioselective Hydronickelation of Allenes and Its Application to the Hydrocyanative Carbocyclization Reaction of Allene–Ynes and Bis-Allenes by Amako, Yuka, Hori, Hiroto, Arai, Shigeru, Nishida, Atsushi

“…The carbocyanative cyclization of allene–ynes and bis-allenes under nickel catalysis is described. The key steps are the regioselective hydronickelation of…”
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Hydrocyanative Cyclization and Three-Component Cross-Coupling Reaction between Allenes and Alkynes under Nickel Catalysis by Arai, Shigeru, Amako, Yuka, Yang, Xiaofei, Nishida, Atsushi

“…Vollgepackt mit Funktionalität: Der Schlüsselschritt in den Titelreaktionen mit Acetoncyanhydrin ist eine regioselektive Hydronickelierung von Allenen…”
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Design and Evaluation of a Cyclobutane Diazirine Alkyne Tag for Photoaffinity Labeling in Cells by West, Alexander V., Amako, Yuka, Woo, Christina M.

“…Alkyl diazirines are frequently used in photoaffinity labeling to map small molecule–protein interactions in target identification studies. However, the alkyl…”
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A chiral trick to map protein ligandability by Amako, Yuka, Woo, Christina M.

“…Biological receptors distinguish between S - and R -enantiomers and these subtle differences in chirality can lead to vastly different protein affinities. Now,…”
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Development of Photolenalidomide for Cellular Target Identification by Lin, Zhi, Amako, Yuka, Kabir, Farah, Flaxman, Hope A, Budnik, Bogdan, Woo, Christina M

“…The thalidomide analogue lenalidomide (Len) is a clinical therapeutic that alters the substrate engagement of cereblon (CRBN), a substrate receptor for the…”
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Nickel-catalyzed [2 + 2] cycloaddition reaction using bisallenes by Arai, Shigeru, Kawata, Yuna, Amako, Yuka, Nishida, Atsushi

“…[Display omitted] •Bisallenes are suitable for [2 + 2] cycloaddition under Ni catalysis.•Xantphos is the best ligand for bisallene…”
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A new protocol for nickel-catalysed regio- and stereoselective hydrocyanation of allenes by Arai, Shigeru, Hori, Hiroto, Amako, Yuka, Nishida, Atsushi

“…Regio- and stereoselective hydrocyanation under nickel catalysis is described. This report shows that allenyl C-C double bonds are discriminated and converted…”
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Selective Divergent Synthesis of Indanols, Indanones, and Indenes via Acid-Mediated Cyclization of (Z)- and (E)‑(2-Stilbenyl)methanols and Its Application for the Synthesis of Paucifloral F Derivatives by Jongcharoenkamol, Jira, Chuathong, Patsapon, Amako, Yuka, Kono, Masato, Poonswat, Kasam, Ruchirawat, Somsak, Ploypradith, Poonsakdi

“…Starting from bromo/iodobenzaldehyde derivatives, the corresponding (Z)- and (E)-(2-stilbenyl)­methanols could be prepared in 2–5 steps via Pd-catalyzed…”
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Regioselective [2+2+2] Cycloaddition Reaction Using Allene‐ynes with Simple Allenes under Nickel Catalysis by Arai, Shigeru, Izaki, Arisa, Amako, Yuka, Nakajima, Masaya, Uchiyama, Masanobu, Nishida, Atsushi

“…A Ni‐catalyzed [2+2+2] cycloaddition reaction between allene‐ynes and various mono‐, di‐ and tri‐substituted allenes is described. This protocol effectively…”
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Front Cover Picture: Regioselective [2+2+2] Cycloaddition Reaction Using Allene‐ynes with Simple Allenes under Nickel Catalysis (Adv. Synth. Catal. 21/2019) by Arai, Shigeru, Izaki, Arisa, Amako, Yuka, Nakajima, Masaya, Uchiyama, Masanobu, Nishida, Atsushi

“…The front cover picture, provided by Shigeru Arai and co‐workers, illustrates new protocols for the [2+2+2] cycloaddition reaction between allene‐ynes and…”
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A general approach to identify cell-permeable and synthetic anti-CRISPR small molecules by Lim, Donghyun, Zhou, Qingxuan, Cox, Kurt J., Law, Benjamin K., Lee, Miseon, Kokkonda, Praveen, Sreekanth, Vedagopuram, Pergu, Rajaiah, Chaudhary, Santosh K., Gangopadhyay, Soumyashree A., Maji, Basudeb, Lai, Sophia, Amako, Yuka, Thompson, David B., Subramanian, Hari K. K., Mesleh, Michael F., Dančík, Vlado, Clemons, Paul A., Wagner, Bridget K., Woo, Christina M., Church, George M., Choudhary, Amit

“…The need to control the activity and fidelity of CRISPR-associated nucleases has resulted in a demand for inhibitory anti-CRISPR molecules. The small-molecule…”
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