Search Results - "Amagasu, S."

Discovery of a selective, state-independent inhibitor of NaV1.7 by modification of guanidinium toxins by Pajouhesh, H., Beckley, J. T., Delwig, A., Hajare, H. S., Luu, G., Monteleone, D., Zhou, X., Ligutti, J., Amagasu, S., Moyer, B. D., Yeomans, D. C., Du Bois, J., Mulcahy, J. V.

“…The voltage-gated sodium channel isoform Na V 1.7 is highly expressed in dorsal root ganglion neurons and is obligatory for nociceptive signal transmission…”
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Glia modulate the response of murine cortical neurons to excitotoxicity: glia exacerbate AMPA neurotoxicity by Dugan, LL, Bruno, VM, Amagasu, SM, Giffard, RG

“…We have developed "pure" neuronal cultures (< 1% astrocytes) from mouse neocortex to study the effect of glial cells on the response of neurons to injury…”
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Volatile anesthetics depress glutamate transmission via presynaptic actions by MACIVER, M. B, MIKULEC, A. A, AMAGASU, S. M, MONROE, F. A

“…Recent evidence for a presynaptic depression of glutamate release produced by volatile anesthetics prompted the current study of isoflurane and halothane…”
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Evidence for a multivalent interaction of symmetrical, N-linked, lidocaine dimers with voltage-gated Na+ channels by Smith, J A M, Amagasu, S M, Hembrador, J, Axt, S, Chang, R, Church, T, Gee, C, Jacobsen, J R, Jenkins, T, Kaufman, E, Mai, N, Vickery, R G

“…The interaction of symmetrical lidocaine dimers with voltage-gated Na+ channels (VGSCs) was examined using a FLIPR membrane potential assay and voltage-clamp…”
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Characterization of prostanoid receptor‐evoked responses in rat sensory neurones by Smith, Jacqueline A M, Amagasu, Shanti M, Eglen, Richard M, Hunter, John C, Bley, Keith R

“…Prostanoid receptor‐mediated sensitization, or excitation, of sensory nerve fibres contributes to the generation of hyperalgesia. To characterize the…”
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Riluzole anesthesia : Use-dependent block of presynaptic glutamate fibers by MACLVER, M. B, AMAGASU, S. M, MIKULEC, A. A, MONROE, F. A

“…Riluzole (RP 54274) is an experimental benzothiazole with anesthetic properties, but little is known about its synaptic or cellular actions. The authors…”
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Halothane depresses action potential conduction in hippocampal axons by Mikulec, Anthony A, Pittson, Sky, Amagasu, Shanti M, Monroe, Frances A, MacIver, M.Bruce

“…General anesthetics are thought to depress the central nervous system (CNS) by acting at synapses; however, only a few studies have compared effects on axonal…”
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Discovery of a selective, state-independent inhibitor of Na V 1.7 by modification of guanidinium toxins by Pajouhesh, H, Beckley, J T, Delwig, A, Hajare, H S, Luu, G, Monteleone, D, Zhou, X, Ligutti, J, Amagasu, S, Moyer, B D, Yeomans, D C, Du Bois, J, Mulcahy, J V

“…The voltage-gated sodium channel isoform Na 1.7 is highly expressed in dorsal root ganglion neurons and is obligatory for nociceptive signal transmission…”
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An in vitro investigation of the cardiovascular effects of the 5-HT4 receptor selective agonists, velusetrag and TD-8954 by Beattie, D.T, Higgins, D.L, Ero, M.P, Amagasu, S.M, Vickery, R.G, Kersey, K, Hopkins, A, Smith, J.A.M

“…Abstract The 5-HT4 receptor agonists, and gastrointestinal (GI) prokinetic agents, cisapride and tegaserod, lack selectivity for the 5-HT4 receptor. Cisapride…”
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Comparison of the pharmacological properties of rat Na(V)1.8 with rat Na(V)1.2a and human Na(V)1.5 voltage-gated sodium channel subtypes using a membrane potential sensitive dye and FLIPR by Vickery, R G, Amagasu, S M, Chang, R, Mai, N, Kaufman, E, Martin, J, Hembrador, J, O'Keefe, M D, Gee, C, Marquess, D, Smith, J A M

“…A novel, membrane potential sensitive dye and a fluorescence imaging plate reader (FLIPR) have been used to characterize the pharmacological properties of rat…”
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An in vitro investigation of the cardiovascular effects of the 5-HT(4) receptor selective agonists, velusetrag and TD-8954 by Beattie, D T, Higgins, D L, Ero, M P, Amagasu, S M, Vickery, R G, Kersey, K, Hopkins, A, Smith, J A M

“…The 5-HT(4) receptor agonists, and gastrointestinal (GI) prokinetic agents, cisapride and tegaserod, lack selectivity for the 5-HT(4) receptor. Cisapride is a…”
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Halothane-induced Depression of Axonal Conduction in Mammalian Central Nervous System Fibers by Amagasu, S. M., Mikulec, A. A., Maclver, M. B.

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Isoflurane and Halothane Produce Opposite Effects on Facilitation of Excitatory Synaptic Responses in CA1 Neurons by Mikulec, A. A., Amagasu, S. M., Monroe, F. A., Maclver, M. B.

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NEURONAL INJURY BY EXCITATORY AMINO ACIDS IS MODULATED BY ASTROCYTES IN CULTURE by Giffard, R. G., Bruno, V. M.G., Amagasu, S. A., Dugan, L. L.

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