Search Results - "Amagase, Kikuko"

An Overview of Acetic Acid Ulcer Models —The History and State of the Art of Peptic Ulcer Research by Okabe, Susumu, Amagase, Kikuko

“…Four types of experimental chronic ulcer models, named acetic acid ulcer models, have been developed to examine the healing process of peptic ulcers, screen…”
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Protective Effect of TRPM8 against Indomethacin-Induced Small Intestinal Injury via the Release of Calcitonin Gene-Related Peptide in Mice by Fouad, Aliaa, Matsumoto, Kenjiro, Amagase, Kikuko, Yasuda, Hiroyuki, Tominaga, Makoto, Kato, Shinichi

“…Transient receptor potential melastatin 8 (TRPM8) is a non-selective cation channel activated by mild cooling and chemical agents including menthol…”
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Apoptosis, Dysbiosis and Expression of Inflammatory Cytokines are Sequential Events in the Development of 5‐Fluorouracil‐Induced Intestinal Mucositis in Mice by Hamouda, Nahla, Sano, Tatsushi, Oikawa, Yosuke, Ozaki, Toru, Shimakawa, Masaki, Matsumoto, Kenjiro, Amagase, Kikuko, Higuchi, Kazuhide, Kato, Shinichi

“…The chemotherapeutic agent 5‐fluorouracil (5‐FU) causes intestinal mucositis with severe diarrhoea, but the pathogenesis is not fully understood. In this…”
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G protein-coupled receptor 35 contributes to mucosal repair in mice via migration of colonic epithelial cells by Tsukahara, Takuya, Hamouda, Nahla, Utsumi, Daichi, Matsumoto, Kenjiro, Amagase, Kikuko, Kato, Shinichi

“…[Display omitted] G protein-coupled receptor 35 (GPR35), a receptor for lysophosphatidic acid, is highly expressed in the gastrointestinal tract. Recently,…”
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Roles of Up-Regulated Expression of ASIC3 in Sex Difference of Acid-Induced Duodenal HCO3 - Responses by Takeuchi, Koji, Ohashi, Yumi, Amagase, Kikuko

“…Although the morbidity of ulcers is statistically higher in males than females, the mechanism of this difference remains unknown. Recent studies show that…”
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Exacerbation of nonsteroidal anti-inflammatory drug-induced small intestinal lesions by antisecretory drugs in rats: the role of intestinal motility by Satoh, Hiroshi, Amagase, Kikuko, Takeuchi, Koji

“…Antisecretory drugs such as histamine H2-receptor antagonists (H2-RAs) and proton pump inhibitors (PPIs) are commonly used for the treatment of gastric and…”
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Probiotic Bifidobacterium bifidum G9‐1 attenuates 5‐fluorouracil‐induced intestinal mucositis in mice via suppression of dysbiosis‐related secondary inflammatory responses by Kato, Shinichi, Hamouda, Nahla, Kano, Yoshitaro, Oikawa, Yousuke, Tanaka, Yoshiki, Matsumoto, Kenjiro, Amagase, Kikuko, Shimakawa, Masaki

“…Summary Bifidobacterium, a major component of the intestinal microbiota, has been clinically used for the treatment of diarrhoea and constipation…”
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Transient receptor potential vanilloid 1 and transient receptor potential ankyrin 1 contribute to the progression of colonic inflammation in dextran sulfate sodium-induced colitis in mice: Links to calcitonin gene-related peptide and substance P by Utsumi, Daichi, Matsumoto, Kenjiro, Tsukahara, Takuya, Amagase, Kikuko, Tominaga, Makoto, Kato, Shinichi

“…Transient receptor potential (TRP) vanilloid 1 (TRPV1) and TRP ankyrin 1 (TRPA1), which are non-selective cation channels, play important roles in the…”
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Leukotriene B4 Receptor Type 2 Accelerates the Healing of Intestinal Lesions by Promoting Epithelial Cell Proliferation by Matsumoto, Yui, Matsuya, Yukiko, Nagai, Kano, Amagase, Kikuko, Saeki, Kazuko, Matsumoto, Kenjiro, Yokomizo, Takehiko, Kato, Shinichi

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Carfilzomib shows therapeutic potential for reduction of liver fibrosis by targeting hepatic stellate cell activation by Fujiwara, Ayana, Takemura, Keisuke, Tanaka, Anna, Matsumoto, Misaki, Katsuyama, Masato, Okanoue, Takeshi, Yamaguchi, Kanji, Itoh, Yoshito, Iwata, Kazumi, Amagase, Kikuko, Umemura, Atsushi

“…Because hepatic stellate cells (HSCs) play a major role in fibrosis, we focused on HSCs as a potential target for the treatment of liver fibrosis. In this…”
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Roles of COX inhibition in pathogenesis of NSAID-induced small intestinal damage by Takeuchi, Koji, Tanaka, Akiko, Kato, Shinichi, Amagase, Kikuko, Satoh, Hiroshi

“…Nonsteroidal anti-inflammatory drugs (NSAIDs) such as indomethacin decrease mucosal PGE 2 content by inhibiting cyclooxygenase (COX) activity and produce…”
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Saireito (TJ-114), a Japanese traditional herbal medicine, reduces 5-fluorouracil-induced intestinal mucositis in mice by inhibiting cytokine-mediated apoptosis in intestinal crypt cells by Kato, Shinichi, Hayashi, Shusaku, Kitahara, Yumeno, Nagasawa, Koyo, Aono, Hitomi, Shibata, Junichiro, Utsumi, Daichi, Amagase, Kikuko, Kadowaki, Makoto

“…Clinical chemotherapy frequently causes intestinal mucositis as a side effect, which is accompanied by severe diarrhea. We recently showed that the…”
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Ciliary Motility Decreased by a CO2/HCO3−-Free Solution in Ciliated Human Nasal Epithelial Cells Having a pH Elevated by Carbonic Anhydrase IV by Okamoto, Shota, Yasuda, Makoto, Kawaguchi, Kotoku, Yasuoka, Kasane, Kikukawa, Yumi, Asano, Shinji, Tsujii, Taisei, Inoue, Sana, Amagase, Kikuko, Inui, Taka-aki, Hirano, Shigeru, Inui, Toshio, Marunaka, Yoshinori, Nakahari, Takashi

“…An application of CO2/HCO3−-free solution (Zero-CO2) did not increase intracellular pH (pHi) in ciliated human nasal epithelial cells (c-hNECs), leading to no…”
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Prostaglandin EP Receptors Involved in Modulating Gastrointestinal Mucosal Integrity by Takeuchi, Koji, Kato, Shinichi, Amagase, Kikuko

“…Endogenous prostaglandins (PGs) play an important role in modulating the mucosal integrity and various functions of the gastrointestinal tract, and E type PGs…”
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Protective mechanisms of glutamine in intestinal diseases by Nahla Hamouda, Shizuka Jonan, Haruto Fukatsu, Kikuko Amagase

“…Glutamine, the most abundant free amino acid in the human body, is a major molecule utilized by intestinal cells. It has been reported that glutamine is…”
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Lubiprostone prevents nonsteroidal anti-inflammatory drug-induced small intestinal damage by suppressing the expression of inflammatory mediators via EP4 receptors by Hayashi, Shusaku, Kurata, Naoto, Yamaguchi, Aya, Amagase, Kikuko, Takeuchi, Koji

“…Lubiprostone, a bicyclic fatty acid derived from prostaglandin E1, has been used to treat chronic constipation and irritable bowel syndrome, and its mechanism…”
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Spiro heterocycles bearing piperidine moiety as potential scaffold for antileishmanial activity: synthesis, biological evaluation, and in silico studies by Mohamed, Mounir A. A., Kadry, Asmaa M., Bekhit, Salma A., Abourehab, Mohammed A. S., Amagase, Kikuko, Ibrahim, Tamer M., El-Saghier, Ahmed M. M., Bekhit, Adnan A.

“…New spiro-piperidine derivatives were synthesised via the eco-friendly ionic liquids in a one-pot fashion. The in vitro antileishmanial activity against…”
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New pyrazolylpyrazoline derivatives as dual acting antimalarial-antileishamanial agents: synthesis, biological evaluation and molecular modelling simulations by Bekhit, Adnan A., Lodebo, Eskedar T., Hymete, Ariaya, Ragab, Hanan M., Bekhit, Salma A., Amagase, Kikuko, Batubara, Afnan, Abourehab, Mohammed A. S., Bekhit, Alaa El-Din A., Ibrahim, Tamer M.

“…Promising inhibitory activities of the parasite multiplication were obtained upon evaluation of in vivo antimalarial activities of new pyrazolylpyrazoline…”
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Cyclooxygenase (COX)-1 and COX-2 both play an important role in the protection of the duodenal mucosa in cats by Satoh, Hiroshi, Amagase, Kikuko, Ebara, Satomi, Akiba, Yasutada, Takeuchi, Koji

“…Although nonsteroidal anti-inflammatory drugs often cause ulcers in the duodenum in humans, the role of cyclooxygenase (COX) isoforms in the pathogenesis of…”
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Irsogladine: overview of the mechanisms of mucosal protective and healing- promoting actions in the gastrointestinal tract by Akagi, Michiyo, Amagase, Kikuko, Murakami, Toshiko, Takeuchi, Koji

“…Irsogladine, a mucosal protective drug, was developed in Japan for the treatment of peptic ulcer disease and acute gastritis. This drug is superior to…”
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