Search Results - "Alzabin, Saba"

Porphyromonas gingivalis facilitates the development and progression of destructive arthritis through its unique bacterial peptidylarginine deiminase (PAD) by Maresz, Katarzyna J, Hellvard, Annelie, Sroka, Aneta, Adamowicz, Karina, Bielecka, Ewa, Koziel, Joanna, Gawron, Katarzyna, Mizgalska, Danuta, Marcinska, Katarzyna A, Benedyk, Malgorzata, Pyrc, Krzysztof, Quirke, Anne-Marie, Jonsson, Roland, Alzabin, Saba, Venables, Patrick J, Nguyen, Ky-Anh, Mydel, Piotr, Potempa, Jan

“…Rheumatoid arthritis and periodontitis are two prevalent chronic inflammatory diseases in humans and are associated with each other both clinically and…”
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Targeting the MAPK7/MMP9 axis for metastasis in primary bone cancer by Green, Darrell, Eyre, Heather, Singh, Archana, Taylor, Jessica T., Chu, Jason, Jeys, Lee, Sumathi, Vaiyapuri, Coonar, Aman, Rassl, Doris, Babur, Muhammad, Forster, Duncan, Alzabin, Saba, Ponthan, Frida, McMahon, Adam, Bigger, Brian, Reekie, Tristan, Kassiou, Michael, Williams, Kaye, Dalmay, Tamas, Fraser, William D., Finegan, Katherine G.

“…Metastasis is the leading cause of cancer-related death. This multistage process involves contribution from both tumour cells and the tumour stroma to release…”
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Companion Diagnostics: State of the Art and New Regulations by Valla, Vasiliki, Alzabin, Saba, Koukoura, Angeliki, Lewis, Amy, Nielsen, Anne Ahlmann, Vassiliadis, Efstathios

“…Companion diagnostics (CDx) hail promise of improving the drug development process and precision medicine. However, there are various challenges involved in…”
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Blockade of tumor necrosis factor in collagen-induced arthritis reveals a novel immunoregulatory pathway for Th1 and Th17 cells by Notley, Clare A, Inglis, Julia J, Alzabin, Saba, McCann, Fiona E, McNamee, Kay E, Williams, Richard O

“…IL-17 is implicated in the pathogenesis of rheumatoid arthritis (RA) and has previously been shown to be induced by tumor necrosis factor (TNF) in vitro. The…”
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Investigation of the role of endosomal Toll-like receptors in murine collagen-induced arthritis reveals a potential role for TLR7 in disease maintenance by Alzabin, Saba, Kong, Philip, Medghalchi, Mino, Palfreeman, Andrew, Williams, Richard, Sacre, Sandra

“…Endosomal toll-like receptors (TLRs) have recently emerged as potential contributors to the inflammation observed in human and rodent models of rheumatoid…”
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Prostaglandin E2 Activates HPK1 Kinase Activity via a PKA-dependent Pathway by Sawasdikosol, Sansana, Pyarajan, Saiju, Alzabin, Saba, Matejovic, Gabriel, Burakoff, Steven J.

“…Hematopoietic progenitor kinase 1 (HPK1) is a hematopoietic cell-restricted member of the Ste20 serine/threonine kinase super family. We recently reported that…”
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IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses by Krausgruber, Thomas, Blazek, Katrina, Smallie, Tim, Alzabin, Saba, Lockstone, Helen, Sahgal, Natasha, Hussell, Tracy, Feldmann, Marc, Udalova, Irina A

“…Macrophages are functionally highly plastic, but the transcriptional control of this process is only partially understood. Udalova and colleagues demonstrate…”
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Effector T cells in rheumatoid arthritis: Lessons from animal models by Alzabin, Saba, Williams, Richard O.

“…The development of an immune response to self antigens drives naive T cells to differentiate into subsets of CD8+ and CD4+ effector cells including TH1, TH2,…”
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Incomplete response of inflammatory arthritis to TNFα blockade is associated with the Th17 pathway by Alzabin, Saba, Abraham, Sonya M, Taher, Taher E, Palfreeman, Andrew, Hull, Dobrina, McNamee, Kay, Jawad, Ali, Pathan, Ejaz, Kinderlerer, Anne, Taylor, Peter C, Williams, Richard, Mageed, Rizgar

“…To establish if changes in Th1/Th17 cell populations previously reported in experimental arthritis occur in patients with rheumatoid arthritis (RA) treated…”
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Hematopoietic Progenitor Kinase 1 Is a Negative Regulator of Dendritic Cell Activation by Alzabin, Saba, Bhardwaj, Nina, Kiefer, Friedemann, Sawasdikosol, Sansana, Burakoff, Steven

“…Hematopoietic progenitor kinase 1 (HPK1) is a hematopoietic cell-restricted member of the Ste20 kinases that acts as a negative regulator of T cell functions…”
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Abstract 1677: Immuno-target selection of infiltrating immune cells and laser capture microdissection mediated transcriptional profiling by Haggart, Ross, Arzola-Donate, Chaxiraxi, Harrison, Elliott, Reed, Benjamin J., Alzabin, Saba, Miele, Gino

“…Abstract Immune checkpoints define an evolving class of inhibitory mediators that are expressed by tumour cells and infiltrating leucocytes to down-modulate…”
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Reporter gene assay for the quantification of the activity and neutralizing antibody response to TNFα antagonists by Lallemand, Christophe, Kavrochorianou, Nadia, Steenholdt, Casper, Bendtzen, Klaus, Ainsworth, Mark A., Meritet, Jean-Francois, Blanchard, Brigitte, Lebon, Pierre, Taylor, Peter, Charles, Peter, Alzabin, Saba, Tovey, Michael G.

“…A cell-based assay has been developed for the quantification of the activity of TNFα antagonists based on human erythroleukemic K562 cells transfected with a…”
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Abstract A12: The Eevaluation of syngeneic animal models for the development of immunotherapeutics in cancer by Batey, Michael A., Alzabin, Saba, Hoyle, Sarah, Otto, Sarah, Bowden, Emma

“…Abstract Background. Cancer immunotherapies are designed to work in conjunction with a patient's immune system to increase native anti-tumour responses, and…”
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Hematopoietic progenitor kinase 1 is a critical component of prostaglandin E2-mediated suppression of the anti-tumor immune response by Alzabin, Saba, Pyarajan, Saiju, Yee, Herman, Kiefer, Friedemann, Suzuki, Akira, Burakoff, Steven, Sawasdikosol, Sansana

“…Lung cancer is the leading cause of cancer-related mortality in the world, resulting in over a million deaths each year. Non-small cell lung cancers (NSCLCs)…”
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HPK1 Influences Regulatory T Cell Functions by Sawasdikosol, Sansana, Zha, Renyuan, Fisher, Timothy S, Alzabin, Saba, Burakoff, Steven J

“…Hematopoietic progenitor kinase 1 (HPK1) is a negative regulator of TCR-initiated signal transduction. Both the mice and the genetically engineered mice with a…”
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Response to Treatment with TNFα Inhibitors in Rheumatoid Arthritis Is Associated with High Levels of GM-CSF and GM-CSF+ T Lymphocytes by Bystrom, Jonas, Clanchy, Felix I., Taher, Taher E., Al-Bogami, Mohammed M., Muhammad, Hawzheen A., Alzabin, Saba, Mangat, Pamela, Jawad, Ali S., Williams, Richard O., Mageed, Rizgar A.

“…Biologic TNFα inhibitors are a mainstay treatment option for patients with rheumatoid arthritis (RA) refractory to other treatment options. However, many…”
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IL-17 induces hyperalgesia via TNF-dependent neutrophil infiltration by McNamee, Kay E., Alzabin, Saba, Hughes, Jane P., Anand, Praveen, Feldmann, Marc, Williams, Richard O., Inglis, Julia J.

“…Interleukin-17 (IL-17) and tumour necrosis factor-α (TNF) are critical in the pathogenesis of arthritis but their relationship during inflammatory pain has…”
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Response to Treatment with TNF[alpha] Inhibitors in Rheumatoid Arthritis Is Associated with High Levels of GM-CSF and GM-CSF.sup.+ T Lymphocytes by Bystrom, Jonas, Clanchy, Felix I, Taher, Taher E, Al-Bogami, Mohammed M, Muhammad, Hawzheen A, Alzabin, Saba, Mangat, Pamela

“…Biologic TNF[alpha] inhibitors are a mainstay treatment option for patients with rheumatoid arthritis (RA) refractory to other treatment options. However, many…”
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Response to Treatment with TNFα Inhibitors in Rheumatoid Arthritis Is Associated with High Levels of GM-CSF and GM-CSF^sup +^ T Lymphocytes by Bystrom, Jonas, Clanchy, Felix I, Taher, Taher E, Al-bogami, Mohammed M, Muhammad, Hawzheen A, Alzabin, Saba, Mangat, Pamela, Jawad, Ali S, Williams, Richard O, Mageed, Rizgar A

“…Biologic TNFα inhibitors are a mainstay treatment option for patients with rheumatoid arthritis (RA) refractory to other treatment options. However, many…”
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Hematopoietic progenitor kinase 1 (HPK1) influences regulatory T cell functions (163.26) by Sawasdikosol, Sansana, Alzabin, Saba, Cary, Chris, Zha, Ren Yuan, Burakoff, Steven

“…Abstract HPK1 is a negative regulator of TCR-initiated signal transduction. HPK1-/- mice are more susceptible to experimental autoimmune encephalomyelitis,…”
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