Histologic characterization of cellular infiltration in autoimmune subepidermal bullous diseases in a tertiary hospital in Saudi Arabia

Histologic characterization of cellular infiltration in autoimmune subepidermal bullous diseases in a tertiary hospital in Saudi Arabia

Autoimmune subepidermal bullous dermatoses have similar clinical features to those of a spectrum of immune reactants at the dermoepidermal junction (DEJ). It is difficult to obtain a precise diagnosis without an immunofluorescence assay because of their similar clinical presentations. The aim of thi...

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Bibliographic Details
Published in:Clinical, cosmetic and investigational dermatology Vol. 11; pp. 187 - 194
Main Authors: BinJadeed, Hessah F, Alyousef, Alanoud M, Alsaif, Fahad M, Alhumidi, Ahmed A, Alotaibi, Homaid O
Format: Journal Article
Language:English
Published: New Zealand Dove Medical Press Limited 01-01-2018
Taylor & Francis Ltd
Dove Medical Press
Subjects:
Abbreviations
Analysis
Bullous pemphigoid
Dermatitis
Dermatitis herpetiformis
Dermatology
Edema
Fluorescent antibody technique
Hospitals
Lupus
Lymphocytes
Medical diagnosis
Medical schools
Medicine
Neutrophils
Original Research
Saudi Arabia
Skin diseases
subepidermal autoimmune bullous disorders
Saudi Arabia
Riyadh Saudi Arabia
Saudi Arabia
subepidermal autoimmune bullous disorders
bullous pemphigoid
pemphigoid gestationis
dermatitis herpetiformis
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Summary:Autoimmune subepidermal bullous dermatoses have similar clinical features to those of a spectrum of immune reactants at the dermoepidermal junction (DEJ). It is difficult to obtain a precise diagnosis without an immunofluorescence assay because of their similar clinical presentations. The aim of this study was to describe the cellular cutaneous infiltration among autoimmune subepidermal bullous dermatoses. This retrospective analysis was conducted at a hospital in Riyadh, Saudi Arabia using biopsy-based data collected from 65 patients. Spongiotic changes, neutrophils, and lymphocyte infiltrations in the epidermis differed among the subepidermal bullous diseases. The DEJ showed a difference in the extent of neutrophil infiltration. The dermis showed differences in perivascular lymphocytic infiltration, neutrophilic infiltration, eosinophilic infiltration, and dermal edema. The dermal and DEJ showed most of the histopathologic changes in subepidermal autoimmune bullous dermatoses.
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ISSN:1178-7015
1178-7015
DOI:10.2147/CCID.S158388