Search Results - "Aly, Lilian"
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Retinal small vessel pathology is associated with disease burden in multiple sclerosis
Published in Multiple sclerosis (01-06-2024)“…Background: Alterations of the superficial retinal vasculature are commonly observed in multiple sclerosis (MS) and can be visualized through optical coherence…”
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Optical coherence tomography angiography indicates subclinical retinal disease in neuromyelitis optica spectrum disorders
Published in Multiple sclerosis (01-04-2022)“…Background: Neuromyelitis optica spectrum disorders (NMOSD) are neuroinflammatory diseases of the central nervous system. Patients suffer from recurring…”
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Aquaporin-4 prevents exaggerated astrocytosis and structural damage in retinal inflammation
Published in Journal of molecular medicine (Berlin, Germany) (01-06-2022)“…Aquaporin-4 (AQP4) is the molecular target of the immune response in neuromyelitis optica (NMO) that leads to severe structural damage in the central nervous…”
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Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation
Published in Cell reports (Cambridge) (12-02-2019)“…Foxp3+ regulatory T (Treg) cells restrict immune pathology in inflamed tissues; however, an inflammatory environment presents a threat to Treg cell identity…”
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Intra- and interscanner variability of magnetic resonance imaging based volumetry in multiple sclerosis
Published in NeuroImage (Orlando, Fla.) (15-11-2016)“…Brain volumetric measurements in multiple sclerosis (MS) reflect not only disease-specific processes but also other sources of variability. The latter has to…”
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Skin and gut imprinted helper T cell subsets exhibit distinct functional phenotypes in central nervous system autoimmunity
Published in Nature immunology (01-07-2021)“…Multidimensional single-cell analyses of T cells have fueled the debate about whether there is extensive plasticity or ‘mixed’ priming of helper T cell subsets…”
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Association of the retinal vasculature, intrathecal immunity, and disability in multiple sclerosis
Published in Frontiers in immunology (11-11-2022)“…Background Optical coherence tomography angiography (OCT-A) is a novel technique allowing non-invasive assessment of the retinal vasculature. During relapsing…”
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Association of retinal vessel pathology and brain atrophy in relapsing-remitting multiple sclerosis
Published in Frontiers in immunology (28-11-2023)“…Optical coherence tomography angiography (OCTA) allows non-invasive assessment of retinal vessel structures. Thinning and loss of retinal vessels is evident in…”
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Increased perfusion in normal appearing white matter in high inflammatory multiple sclerosis patients
Published in PloS one (16-03-2015)“…Although cerebral perfusion alterations have long been acknowledged in multiple sclerosis (MS), the relationship between measurable perfusion changes and the…”
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Central role of JC virus-specific CD4+ lymphocytes in progressive multi-focal leucoencephalopathy-immune reconstitution inflammatory syndrome
Published in Brain (London, England : 1878) (01-09-2011)“…Progressive multi-focal leucoencephalopathy and progressive multi-focal leucoencephalopathy-immune reconstitution inflammatory syndrome are caused by infection…”
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Treatment- and population-specific genetic risk factors for anti-drug antibodies against interferon-beta: a GWAS
Published in BMC medicine (04-11-2020)“…Upon treatment with biopharmaceuticals, the immune system may produce anti-drug antibodies (ADA) that inhibit the therapy. Up to 40% of multiple sclerosis…”
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From Leflunomide to Teriflunomide: Drug Development and Immunosuppressive Oral Drugs in the Treatment of Multiple Sclerosis
Published in Current neuropharmacology (01-01-2017)“…Background: Immunosuppressive drugs have been used in the treatment of multiple sclerosis (MS) for a long time. Today, orally available second generation…”
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T Cell Epitope Mapping of JC Polyoma Virus-Encoded Proteome Reveals Reduced T Cell Responses in HLA-DRB104:01+ Donors
Published in Journal of Virology (01-03-2013)“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Correction: Increased Perfusion in Normal Appearing White Matter in High Inflammatory Multiple Sclerosis Patients
Published in PloS one (04-11-2015)Get full text
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Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells
Published in Nature immunology (2017)“…Korn and colleagues report that Sirpα + dendritic cells trans-present the cytokine IL-6 to T cells through a process that requires its receptor IL-6Rα bound to…”
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Multiple sclerosis: is it all black and white in optical coherence tomography?
Published in Brain (London, England : 1878) (01-11-2018)“…This scientific commentary refers to 'Brain and retinal atrophy in African-Americans versus Caucasian-Americans with multiple sclerosis: a longitudinal study',…”
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Retinal inner nuclear layer volume reflects response to immunotherapy in multiple sclerosis
Published in Brain (London, England : 1878) (01-11-2016)Get full text
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Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic T H 17 cells
Published in Nature immunology (01-01-2017)“…The cellular sources of interleukin 6 (IL-6) that are relevant for differentiation of the T 17 subset of helper T cells remain unclear. Here we used a novel…”
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COVID-19 distresses the depressed while schizophrenic patients are unimpressed: A study on psychiatric inpatients
Published in Psychiatry research (01-09-2020)Get full text
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Myeloid-derived suppressor cells control B cell accumulation in the central nervous system during autoimmunity
Published in Nature immunology (01-12-2018)“…Polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) have been characterized in the context of malignancies. Here we show that PMN-MDSCs can restrain…”
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