Search Results - "Alvine, Travis"

Dengue virus specific IgY provides protection following lethal dengue virus challenge and is neutralizing in the absence of inducing antibody dependent enhancement by Fink, Ashley L, Williams, Katherine L, Harris, Eva, Alvine, Travis D, Henderson, Thomas, Schiltz, James, Nilles, Matthew L, Bradley, David S

“…Dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) are severe disease manifestations that can occur following sequential infection with different…”
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Characterization of prostanoids response to Bordetella pertussis antigen BscF and Tdap in LPS-challenged monocytes by Raihan, Md.Obayed, Espelien, Brenna M., Hanson, Courtney, McGregor, Brett A., Velaris, Nathan A., Alvine, Travis D., Al. Golovko, Svetlana, Bradley, David S., Nilles, Matthew, Glovko, Mikhail Y., Hur, Junguk, Porter, James E.

“…•These results are the first to demonstrate a regulatory role for BscF and Tdap in prostanoids production.•BscF, alone elicit immunomodulatory effect…”
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Mouse Immunization with Purified Needle Proteins from Type III Secretion Systems and the Characterization of the Immune Response to These Proteins by Alvine, Travis D, Bradley, David S, Nilles, Matthew L

“…Many Gram-negative pathogens utilize a type III secretion (T3S) system to directly deliver effector molecules into host eukaryotic cells to manipulate cellular…”
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Modulation of Inflammatory Signaling Molecules in Bordetella pertussis Antigen-Challenged Human Monocytes in Presence of Adrenergic Agonists by Raihan, Md Obayed, Espelien, Brenna M, McGregor, Brett A, Hanson, Courtney, Brishti, Afrina, Velaris, Nathan A, Alvine, Travis D, Bradley, David S, Nilles, Matthew, Golovko, Mikhail Y, Hur, Junguk, Porter, James E

“…BscF is a type III secretion system (T3SS) needle protein from and has previously been shown to induce a sufficient Th1 and Th17 response in human monocytes…”
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Endogenous HLA-DQ8αβ programs superantigens (SEG/SEI) to silence toxicity and unleash a tumoricidal network with long-term melanoma survival by Knopick, Peter, Terman, David, Riha, Nathan, Alvine, Travis, Larson, Riley, Badiou, Cedric, Lina, Gerard, Ballantyne, John, Bradley, David

“…BackgroundAs the most powerful T cell agonists known, superantigens (SAgs) have enormous potential for cancer immunotherapy. Their development has languished…”
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Expression and Purification of N-Terminally His-Tagged Recombinant Type III Secretion Proteins by Alvine, Travis D, Osei-Owusu, Patrick, Condry, Danielle L Jessen, Nilles, Matthew L

“…The ability to express and purify recombinant needle proteins from the Type III Secretion System (T3SS) of many gram-negative bacteria has allowed us to…”
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A Method for Characterizing the Type III Secretion System's Contribution to Pathogenesis: Homologous Recombination to Generate Yersinia pestis Type III Secretion System Mutants by Osei-Owusu, Patrick, Nilles, Matthew L, Bradley, David S, Alvine, Travis D

“…The type III (T3S) secretion system of many gram-negative bacteria is a surface-exposed protein secretion apparatus used to directly inject bacterial effector…”
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Nutrients and Immunometabolism: Role of Macrophage NLRP3 by Claycombe-Larson, Kate J, Alvine, Travis, Wu, Dayong, Kalupahana, Nishan S, Moustaid-Moussa, Naima, Roemmich, James N

“…Inflammation is largely mediated by immune cells responding to invading pathogens, whereas metabolism is oriented toward producing usable energy for vital cell…”
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BscF as a vaccine candidate for Bordetella   pertussis infection (“Whooping Cough”) (VAC9P.1064) by Alvine, Travis, Ganske, Alec, Nilles, Matthew, Bradley, David

“…Bordetella pertussis, a Gram- bacterium, causes pertussis (“Whopping Cough”). Despite widespread vaccination, 48 million cases of pertussis occur annually…”
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Purified type III secretion system needle proteins are novel TLR agonists that induce NF-κB signaling and stimulate NLRP3-dependent IL-1β production by innate cells in vitro by Alvine, Travis D, Knopick, Peter L, Nilles, Matthew L, Bradley, David S

“…Purified type III secretion (T3S) system needle proteins from a number of Gram-negative bacteria have been identified as protective antigens as well as strong…”
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Effect of HLA-DQ presentation on SEG/SEI superantigenic reactivity to a CD4+-mediated anti-tumor response devoid of autoimmune or allogeneic effects by Knopick, Peter, Benedict, Katherine, Alvine, Travis, Nilles, Matthew, Ballantyne, John, Terman, David, Bradley, David

“…Abstract only…”
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Temperature-dependent sex determination modulates cardiovascular maturation in embryonic snapping turtles Chelydra serpentina by Alvine, Travis, Rhen, Turk, Crossley, 2nd, Dane A

“…We investigated sex differences in cardiovascular maturation in embryos of the snapping turtle Chelydra serpentina, a species with temperature-dependent sex…”
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BscF from Bordetella pertussis provides advantageous adjuvant activity when paired with the acellular pertussis vaccine: enhanced Th1/Th17 pertussis-specific immune response by Alvine, Travis D, Knopick, Peter L, Kumar, Meera Ajeet, Nilles, Matthew L, Bradley, David S

“…Incidence of pertussis, a severe respiratory disease caused by Bordetella pertussis, have been on the rise. This resurgence has been linked to antigenic…”
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The N terminus of Yersinia pestis’ YscF masks YscF’s naturally occurring PAMP, inhibiting inflammation and allowing for colonization in vivo by O’Donnell, Kyle Lee, Alvine, Travis D, Osei-Owusu, Patrick, Niles, Matthew, Bradley, David

“…Type III secretion (T3S) systems, common to many Gram- bacteria, act as a needle to deliver virulence factors directly into eukaryotic cells, often modulating…”
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Humanized HLA-DQ8αβ transgenic mice treated with SEG/SEI superantigens exhibit long-term CD4+-mediated anti-tumor responses by Knopick, Peter Leo, Alvine, Travis D, Biswas, Nivedita, Nilles, Matthew L, Terman, David S, Bradley, David S

“…SEG and SEI are primordial S. aureus superantigens (SAgs) notably unaccompanied by human neutralizing antibodies that have hampered the use of classic SAgs as…”
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Paternal High Fat Diet and Exercise Differentially Regulate Placental Development and Inflammation in a Sex-Specific Manner in C57BL6/J Mice (P19-003-19) by Larson, Kate, Bundy, Amy, Alvine, Travis, Roemmich, James

“…We have shown that increases in T2D risk in male offspring when the father consumes a high-fat (HF) diet can be normalized when the father also exercises…”
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Staphylococcal enterotoxin G and I: augmenting the T cell response to murine melanoma by Knopick, Peter Leo, Benedict, Katherine C, Alvine, Travis D, Nilles, Matthew L, Terman, David S, Bradley, David S

“…Staphylococcal enterotoxins (SEs) have been shown to be effectual proteins which demonstrate anti-tumor activity. SEG and SEI, produced from the enterotoxin…”
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Renal, metabolic and hematological effects of trans-retinoic acid during critical developmental windows in the embryonic chicken by Alvine, Travis, Burggren, Warren W.

“…All-trans-retinoic acid (tRA), an active metabolite of vitamin A, directly influences the developing kidney, and is a major regulatory signal during vertebrate…”
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Offspring Exercise Modulates Beige Adipocyte Numbers by Differential Regulation of H3K9 Methyltransferase G9a and Demethylase KDM4C in Mice Fed a Maternal High Fat Diet (P21-067-19) by Larson, Kate, Bundy, Amy, Alvine, Travis, Lance, Elizabeth Black, Roemmich, James

“…We have shown that a maternal low protein and postnatal high fat (HF) diet increases offspring obesity and type 2 diabetes mellitus (T2DM) risk by…”
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Characterization of the Immune Stimulating Properties of Type III Secretion System Needle Protein BscF from Bordetella Pertussis : Towards the Development of a New Acellular Pertussis Vaccine by Alvine, Travis Douglas

“…Despite widespread vaccination, Bordetella pertussis , the causative agent of whooping cough, is still a threat to global health. One cause of pertussis…”
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