Correlation of Clinical, Histological, and Cytokeratin Profiles of Squamous Cell Carcinoma of the Oral Tongue With Prognosis

Correlation of Clinical, Histological, and Cytokeratin Profiles of Squamous Cell Carcinoma of the Oral Tongue With Prognosis

The aim of the present study was to clinically, morphologically, and immunohistochemically correlate the expression of cytokeratins (CKs) 7, 10, 13, 14, 16, and 19 in 30 cases of tongue squamous cell carcinoma (SCC) with disease outcome, metastases, clinical stage (tumor, node, metastasis [TNM]), an...

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Bibliographic Details
Published in:International journal of surgical pathology Vol. 15; no. 4; pp. 376 - 383
Main Authors: Dantas da Silveira, Ericka Janine, Pina Godoy, Gustavo, AlvesUchôa Lins, Ruthinéia Diógenes, Silva Arruda, Maria de Lourdes, Formiga Ramos, Carlos Cesar, de Almeida Freitas, Roseana, Guedes Queiroz, Lélia Maria
Format: Journal Article
Language:English
Published: Los Angeles, CA SAGE Publications 01-10-2007
Subjects:
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor - metabolism
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - mortality
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - therapy
Combined Modality Therapy
Disease-Free Survival
Female
Humans
Immunohistochemistry - methods
Keratins - metabolism
Male
Middle Aged
Remission Induction
Retrospective Studies
Survival Rate
Tongue Neoplasms - metabolism
Tongue Neoplasms - mortality
Tongue Neoplasms - pathology
Tongue Neoplasms - therapy
metastases
histological grading
immunohistochemistry
TNM classification
tongue squamous cell carcinoma
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Summary:The aim of the present study was to clinically, morphologically, and immunohistochemically correlate the expression of cytokeratins (CKs) 7, 10, 13, 14, 16, and 19 in 30 cases of tongue squamous cell carcinoma (SCC) with disease outcome, metastases, clinical stage (tumor, node, metastasis [TNM]), and histological grade of malignancy proposed by Bryne. Statistical analysis (χ2 test) showed that only histological grading was not significantly correlated with the clinical variables. CK expression varied in the samples analyzed. CK 10 expression was significantly correlated with the presence of metastases, and the expression of CK 16 was related to disease outcome and also to TNM stages III and IV. These results indicate that metastases and TNM are effective prognostic indicators. The histological grading proposed by Bryne did not reflect the biological behavior of the tongue SCC cases studied. Analysis of some intermediate CK filaments can reflect the biological behavior and aggressiveness of some tongue SCCs.
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ISSN:1066-8969
1940-2465
DOI:10.1177/1066896907304992