Antibacterial and antibiotic-modifying activity of the commercialized essential oil of Copaifera spp. Associated with LED lights against a Staphylococcus aureus strain

[Display omitted] •The EOs of Copaifera spp. has a promising potential in modifying the antibiotic activity;•The combination with the red LED light potentiated the antibacterial activity of the EOs;•The red LED light potentiated the antibiotic activity against MDR bacteria; Copaiba oil is widely use...

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Bibliographic Details
Published in:	Journal of functional foods Vol. 114; p. 106075
Main Authors:	Alves de Lima Sampaio, Milena, Carolina Justino de Araújo, Ana, Arthur de Oliveira Borges, João, Mariana Gonçalves Lima, Clara, Douglas Melo Coutinho, Henrique, Ramos Freitas, Priscilla, Emran, Talha Bin, Obaidullah, Ahmad J., Olinda Macedo da Silva, Rakel
Format:	Journal Article
Language:	English
Published:	Elsevier Ltd 01-03-2024 Elsevier
Subjects:	Antibacterial Copaiba Modulating activity Phototherapy Copaiba Antibacterial Modulating activity Phototherapy
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Summary:	[Display omitted] •The EOs of Copaifera spp. has a promising potential in modifying the antibiotic activity;•The combination with the red LED light potentiated the antibacterial activity of the EOs;•The red LED light potentiated the antibiotic activity against MDR bacteria; Copaiba oil is widely used in medicine due to its antibacterial, anti-inflammatory, healing, antiviral, antiseptic and analgesic properties. Thus, the main objective of the study is to evaluate the antibacterial activity and modifier of the antibiotic action of the commercialized essential oil of four species of Copaifera spp. in combination with Ampicillin and LED lights against the multidrug-resistant strain of S. aureus (SA 10). The essential oil was obtained commercially through the dōTERRA® company. The evaluation of the antibacterial and modulating activity was performed using the microdilution methodology in a 96-well plate, using blue 415 nm, red 620 nm and yellow 590 nm LEDs and Ampicillin at an initial concentration of 1.024 µg/mL. The experiments were carried out in triplicate and submitted to ANOVA statistical analysis, considering a significant value of p < 0,05. The essential oil of Copaifera spp. did not show antibacterial activity alone, but showed significant modifying activity when combined with Ampicillin in the absence of LED and with red LED. However, the yellow LED and the blue LED had no significant modulating effect. The results suggest the presence of an enzymatic mechanism of resistance, indicating relevance for the development of future scientific research, aiming to help in the treatment of lesions caused by multiresistant pathogens.
ISSN:	1756-4646 2214-9414
DOI:	10.1016/j.jff.2024.106075