Search Results - "Alves, Nuno Dinis"
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Cell cycle regulation of hippocampal progenitor cells in experimental models of depression and after treatment with fluoxetine
Published in International journal of molecular sciences (30-10-2021)“…Changes in adult hippocampal cell proliferation and genesis have been largely implicated in depression and antidepressant action, though surprisingly, the…”
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2
Constitutive deficiency of the neurogenic hippocampal modulator AP2γ promotes anxiety-like behavior and cumulative memory deficits in mice from juvenile to adult periods
Published in eLife (03-12-2021)“…The transcription factor activating protein two gamma (AP2γ) is an important regulator of neurogenesis both during embryonic development as well as in the…”
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3
Region-specific control of microglia by adenosine A2A receptors: uncoupling anxiety and associated cognitive deficits in female rats
Published in Glia (01-01-2019)“…Epidemiologic studies have provided compelling evidence that prenatal stress, through excessive maternal glucocorticoids exposure, is associated with…”
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4
Editorial: Neural Plasticity and Behavioral Responses to Adversity
Published in Frontiers in behavioral neuroscience (01-07-2022)“…Editorial on the Research Topic Neural Plasticity and Behavioral Responses to Adversity The mammalian brain has a remarkable capacity to overcome internal…”
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5
miR-409 and miR-411 Modulation in the Adult Brain of a Rat Model of Depression and After Fluoxetine Treatment
Published in Frontiers in behavioral neuroscience (07-08-2020)“…Depression is a chronic debilitating disorder predicted to affect around 20% of the world population. Both brain and peripheral changes, including neuroplastic…”
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6
Suppression of adult cytogenesis in the rat brain leads to sex‐differentiated disruption of the HPA axis activity
Published in Cell proliferation (01-02-2022)“…Objectives The action of stress hormones, mainly glucocorticoids, starts and coordinates the systemic response to stressful events. The HPA axis activity is…”
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Beyond new neurons in the adult hippocampus: imipramine acts as a pro-astrogliogenic factor and rescues cognitive impairments induced by stress exposure
Published in Cells (Basel, Switzerland) (24-01-2022)“…Depression is a prevalent, socially burdensome disease. Different studies have demonstrated the important role of astrocytes in the pathophysiology of…”
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8
The Sweet Drive Test: refining phenotypic characterization of anhedonic behavior in rodents
Published in Frontiers in behavioral neuroscience (07-03-2014)“…Measuring anhedonic behavior in rodents is a challenging task as current methods display only moderate sensitivity to detect anhedonic phenotype and,…”
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AP2γ: A New Player on Adult Hippocampal Neurogenesis Regulation
Published in Journal of experimental neuroscience (2018)“…Since the recognition that the mammalian brain retains the ability to generate newborn neurons with functional relevance throughout life, the matrix of…”
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10
Glial-restricted precursors stimulate endogenous cytogenesis and effectively recover emotional deficits in a model of cytogenesis ablation
Published in Molecular psychiatry (01-07-2024)“…Adult cytogenesis, the continuous generation of newly-born neurons (neurogenesis) and glial cells (gliogenesis) throughout life, is highly impaired in several…”
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Hippocampal cytogenesis abrogation impairs inter-regional communication between the hippocampus and prefrontal cortex and promotes the time-dependent manifestation of emotional and cognitive deficits
Published in Molecular psychiatry (01-12-2021)“…Impaired ability to generate new cells in the adult brain has been linked to deficits in multiple emotional and cognitive behavioral domains. However, the…”
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12
Region-specific control of microglia by adenosine A 2A receptors: uncoupling anxiety and associated cognitive deficits in female rats
Published in Glia (01-01-2019)“…Epidemiologic studies have provided compelling evidence that prenatal stress, through excessive maternal glucocorticoids exposure, is associated with…”
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Journal Article -
13
Adult hippocampal neuroplasticity triggers susceptibility to recurrent depression
Published in Translational psychiatry (14-03-2017)“…Depression is a highly prevalent and recurrent neuropsychiatric disorder associated with alterations in emotional and cognitive domains. Neuroplastic phenomena…”
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The modulation of adult neuroplasticity is involved in the mood-improving actions of atypical antipsychotics in an animal model of depression
Published in Translational psychiatry (06-06-2017)“…Depression is a prevalent psychiatric disorder with an increasing impact in global public health. However, a large proportion of patients treated with…”
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15
StressMatic: a novel automated system to induce depressive- and anxiety-like phenotype in rats
Published in Cells (Basel, Switzerland) (20-01-2023)“…Major depressive disorder (MDD) is a multidimensional psychiatric disorder that is estimated to affect around 350 million people worldwide. Generating valid…”
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Adult Neural Plasticity in the Pathophysiology of Depression: New Insights from an Animal Model of Recurrence
Published 01-01-2017“…Depression is a high prevalent and recurrent neuropsychiatry disorder that has a huge impact in patient’s life. Despite the large number of studies focusing on…”
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Dissertation -
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Adult hippocampal cytogenesis: Behavioral correlates and function in the female brain
Published in IBRO reports (01-09-2019)Get full text
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