Search Results - "Alves, Marco L."

Molecular and Functional Characterization of a Novel Cardiac-Specific Human Tropomyosin Isoform by RAJAN, Sudarsan, JAGATHEESAN, Ganapathy, DUBE, Dipak K, PETRASHEVSKAYA, Natalia, HERR, Andrew B, HULLIN, Roger, LIGGETT, Stephen B, WOLSKA, Beata M, SOLARO, R. John, WIECZOREK, David F, KARAM, Chehade N, ALVES, Marco L, BODI, Ilona, SCHWARTZ, Arnold, BULCAO, Christian F, D'SOUZA, Karen M, AKHTER, Shahab A, BOIVIN, Greg P

“…Tropomyosin (TM), an essential actin-binding protein, is central to the control of calcium-regulated striated muscle contraction. Although TPM1alpha (also…”
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Early sensitization of myofilaments to Ca2+ prevents genetically linked dilated cardiomyopathy in mice by Alves, Marco L, Warren, Chad M, Simon, Jillian N, Gaffin, Robert D, Montminy, Eric M, Wieczorek, David F, Solaro, R John, Wolska, Beata M

“…Dilated cardiomoypathies (DCM) are a heterogeneous group of inherited and acquired diseases characterized by decreased contractility and enlargement of cardiac…”
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Desensitization of myofilaments to Ca2+ as a therapeutic target for hypertrophic cardiomyopathy with mutations in thin filament proteins by Alves, Marco L, Dias, Fernando A L, Gaffin, Robert D, Simon, Jillian N, Montminy, Eric M, Biesiadecki, Brandon J, Hinken, Aaron C, Warren, Chad M, Utter, Megan S, Davis, Rd, Robert T, Sakthivel, Sadayappan, Robbins, Jeffrey, Wieczorek, David F, Solaro, R John, Wolska, Beata M

“…Hypertrophic cardiomyopathy (HCM) is a common genetic disorder caused mainly by mutations in sarcomeric proteins and is characterized by maladaptive myocardial…”
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Rescue of familial cardiomyopathies by modifications at the level of sarcomere and Ca2+ fluxes by Alves, Marco L, Gaffin, Robert D, Wolska, Beata M

“…Abstract Cardiomyopathies are a heterogeneous group of diseases of the myocardium associated with mechanical and/or electrical dysfunction that frequently show…”
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Circulating miR-1 as a potential biomarker of doxorubicin-induced cardiotoxicity in breast cancer patients by Rigaud, Vagner Oliveira-Carvalho, Ferreira, Ludmila R P, Ayub-Ferreira, Silvia M, Ávila, Mônica S, Brandão, Sara M G, Cruz, Fátima D, Santos, Marília H H, Cruz, Cecilia B B V, Alves, Marco S L, Issa, Victor S, Guimarães, Guilherme V, Cunha-Neto, Edécio, Bocchi, Edimar A

“…Cardiotoxicity is associated with the chronic use of doxorubicin leading to cardiomyopathy and heart failure. Identification of cardiotoxicity-specific miRNA…”
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Long-term rescue of a familial hypertrophic cardiomyopathy caused by a mutation in the thin filament protein, tropomyosin, via modulation of a calcium cycling protein by Gaffin, Robert D, Peña, James R, Alves, Marco S.L, Dias, Fernando A.L, Chowdhury, Shamim A.K, Heinrich, Lynley S, Goldspink, Paul H, Kranias, Evangelia G, Wieczorek, David F, Wolska, Beata M

“…Abstract We have recently shown that a temporary increase in sarcoplasmic reticulum (SR) cycling via adenovirus-mediated overexpression of sarcoplasmic…”
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Effects of nicotine administration in a mouse model of familial hypertrophic cardiomyopathy, α-tropomyosin D175N by Gaffin, Robert D, Chowdhury, Shamim A K, Alves, Marco S L, Dias, Fernando A L, Ribeiro, Cibele T D, Fogaca, Rosalvo T H, Wieczorek, David F, Wolska, Beata M

“…The effects of nicotine (NIC) on normal hearts are fairly well established, yet its effects on hearts displaying familial hypertrophic cardiomyopathy have not…”
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Desensitization of Myofilaments to Ca 2+ as a Therapeutic Target for Hypertrophic Cardiomyopathy With Mutations in Thin Filament Proteins by Alves, Marco L., Dias, Fernando A.L., Gaffin, Robert D., Simon, Jillian N., Montminy, Eric M., Biesiadecki, Brandon J., Hinken, Aaron C., Warren, Chad M., Utter, Megan S., Davis, Robert T., Sadayappan, Sakthivel, Robbins, Jeffrey, Wieczorek, David F., Solaro, R. John, Wolska, Beata M.

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