Chronic treatment with ascorbic acid enhances cortical spreading depression in developing well-nourished and malnourished rats

► We explore whether vitamin C alters cortical spreading depression in rats. ►The modulation of this effect by malnutrition was also studied. ► Results demonstrate a CSD-facilitation by vitamin C regardless of nutritional status. ► Vit C may act as prooxidant in view of the contrasting effect on CSD...

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Published in:	Neuroscience letters Vol. 496; no. 3; pp. 191 - 194
Main Authors:	Monte-Guedes, Cinthia K.R., Alves, Erica V.S., Viana-da-Silva, Eveline, Guedes, Rubem C.A.
Format:	Journal Article
Language:	English
Published:	Shannon Elsevier Ireland Ltd 08-06-2011 Elsevier
Subjects:	Animals Antioxidants Antioxidants - pharmacology Ascorbic Acid - pharmacology Biological and medical sciences Body Weight - drug effects Brain - growth & development Brain development Cortical spreading depression Cortical Spreading Depression - drug effects Electroencephalography Electrophysiological Phenomena Enteral Nutrition Fundamental and applied biological sciences. Psychology Malnutrition Malnutrition - physiopathology Medical sciences Membrane Potentials - drug effects Membrane Potentials - physiology Metabolic diseases Nutritional Status - physiology Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...) Potassium Chloride - pharmacology Prooxidants Rats Rats, Wistar Vertebrates: nervous system and sense organs Vitamin C AA EEG Cortical spreading depression Brain development Nv i.p M Antioxidants SD CSD RBD ECoG W Vitamin C Malnutrition DC Sal Prooxidants Ascorbic acid Rat Rodentia Central nervous system Nutrition disorder Vitamin Antioxidant Encephalon Micronutrient Vertebrata Chronic Mammalia Animal Development Spreading depression
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Summary:	► We explore whether vitamin C alters cortical spreading depression in rats. ►The modulation of this effect by malnutrition was also studied. ► Results demonstrate a CSD-facilitation by vitamin C regardless of nutritional status. ► Vit C may act as prooxidant in view of the contrasting effect on CSD as compared with other antioxidants. Ascorbic acid (AA) is an antioxidant molecule that is highly concentrated in the brain and can exert both anticonvulsant and proconvulsant effects in distinct models of experimental seizures. Herein, we investigated whether chronic AA administration alters cortical excitability as indexed by the cortical spreading depression (CSD). Well-nourished (W) and malnourished (M) rats were treated, by gavage, with 60mg/kg/day of l-AA from postnatal days 7–28, and CSD propagation was analyzed at 30–40 days. Compared to the W groups, M rats presented higher (p<0.05) CSD amplitudes and velocities of propagation. In both nutritional conditions, AA-treatment significantly increased CSD amplitudes and propagation velocities (p<0.05), as compared to non-treated (‘naïve’; Nv) and saline-treated (Sal) controls. The mean±standard deviation CSD velocities of propagation (in mm/min) for the Sal, AA and Nv groups were respectively 3.75±0.03, 4.26±0.08 and 3.81±0.04 for the W condition and 4.29±0.08, 4.51±0.04 and 4.30±0.04 for the M groups. The results demonstrate a CSD-facilitation by AA regardless of nutritional status. They also suggest that, at the dose of 60mg/kg/day chronically administered during brain development, AA may act as a prooxidant in brain, in view of the contrasting effect as compared with other antioxidants, which reduce CSD.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1
ISSN:	0304-3940 1872-7972
DOI:	10.1016/j.neulet.2011.04.025